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Application of sodium hydrogen sulfite andrographolide in preparation of promoter for promoting reverse transport of cholesterol

A technology of reverse cholesterol transport and andrographolide, which can be applied in application, cardiovascular system diseases, function of food ingredients, etc., can solve problems such as increasing high-density lipoprotein cholesterol

Active Publication Date: 2019-12-13
GUANGANMEN HOSPITAL CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a new use of sodium bisulfite andrographolide for the existing technical problems of high blood fat and cholesterol accumulation in the cells of existing cardiovascular diseases, which lead to atherosclerotic lesions. Cholesterol from intracellular reverse transport promoters, anti-atherosclerotic cholesterol reverse transport promoters, anti-atherosclerotic drugs, drugs for the treatment of hyperlipidemia, new applications in drugs for the treatment of cardiovascular diseases, sodium bisulfite Andrographolide is used for anti-atherosclerosis, reducing intracellular cholesterol content, reversely transporting intracellular cholesterol to the outside of the cell, inhibiting the accumulation of cholesterol between smooth muscle cell collagen and elastic fibers, avoiding smooth muscle cell proliferation, and regulating blood lipids. Lower serum cholesterol, triglycerides and low-density lipoprotein cholesterol, while increasing high-density lipoprotein cholesterol

Method used

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  • Application of sodium hydrogen sulfite andrographolide in preparation of promoter for promoting reverse transport of cholesterol
  • Application of sodium hydrogen sulfite andrographolide in preparation of promoter for promoting reverse transport of cholesterol
  • Application of sodium hydrogen sulfite andrographolide in preparation of promoter for promoting reverse transport of cholesterol

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0084] Embodiment 1 prepares sodium bisulfite andrographolide

[0085] 1. Preparation of andrographolide

[0086] After the medicinal material Andrographis paniculata (1kg) is crushed into coarse powder, add ethanol solution (mass concentration is 75%, usually 50-75%), heat and reflux extraction, the number of times of extraction is 2 times (usually 2-3 times), each time The volume of the ethanol solution during extraction is 5L (usually 5-20L), that is, the volume ratio of the volume of the ethanol solution to the Andrographis paniculata medicinal material is 5-20:1 during each extraction.

[0087] The extract is concentrated under reduced pressure until it has no alcohol smell, and the extract-concentrate is obtained. The temperature of the concentration under reduced pressure is 70°C, and the relative vacuum is -0.09~-0.075MPa. The weight of the extract-concentrate and the raw material The weight ratio of Andrographis paniculata is 1:1 (usually 1-5:1).

[0088] Add activa...

Embodiment 2

[0135] The effect of embodiment 2 sodium bisulfite andrographolide on APOE mice

[0136] 1. Experimental materials

[0137] 100 8-week-old male APOE (- / -) mice and 10 wild-type (wide type, WT) C57BL / 6J mice, weighing 22±2g, were purchased from Beijing Weitong Lihua Company.

[0138] Medicine is identical with embodiment 2.

[0139] 2. Grouping and intervention methods

[0140] All mice were randomly grouped according to body weight after adaptive feeding for 1 week, and the groups were as follows:

[0141] Normal control group (C57 group): 10 C57BL / 6J mice were given normal diet + normal saline.

[0142] Model control group (Model group): 10 APOE (- / -) mice fed with high cholesterol diet + normal saline.

[0143] Positive control group (ATOR group, Atorvastatin group): 10 APOE (- / -) mice fed with high cholesterol diet + atorvastatin calcium (10 mg / kg / d) orally.

[0144] Sodium bisulfite andrographolide high-dose group (A high group): 10 APOE (- / -) mice were given a high-c...

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Abstract

The invention discloses an application of sodium hydrogen sulfite andrographolide in preparation of a promoter for promoting reverse transport of cholesterol, and relates to an application of a medicine for resisting atherosclerosis. The tests prove that the sodium hydrogen sulfite andrographolide has a remarkable curative effect of promoting reverse transportation of cholesterol in cells and resisting atherosclerosis, takes effect quickly, has small toxic and side effects, particularly has no influence on liver and kidney functions, is a safe, efficient and stable medicine or a health care product for treating and conditioning cardiovascular diseases, is suitable for industrial production and is easy to popularize. Therefore, a new field is developed for the application of the sodium hydrogen sulfite andrographolide, and a new medicine source is provided for promoting reverse transportation of intracellular cholesterol, reducing the content of intracellular cholesterol and preventingand treating atherosclerosis and cardiovascular diseases.

Description

technical field [0001] The invention relates to a compound capable of regulating blood lipids and preventing the development of atherosclerotic heart disease, a preparation method and application thereof, in particular to an anti-atherosclerosis cholesterol reverse transport accelerator, a preparation method and its application. application. Background technique [0002] Cardiovascular disease (CVD), including unstable angina, stroke, acute myocardial infarction with or without ST-segment elevation, and sudden coronary death, is the leading cause of cardiovascular morbidity and mortality worldwide. Most cardiac deaths are due to coronary atherosclerotic heart disease. In my country's Beijing area, the average annual growth rate of the incidence of acute coronary heart disease events from 1984 to 1993 was 2.3%. Nationally, the average annual growth rate of the incidence of acute coronary events from 1984 to 1997 was 1.7%. [0003] Coronary heart disease, also known as coro...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61P3/06A61P9/10A61P9/00A61P25/20A61P9/06A61P13/12A61P1/14A61P1/10C07D307/58A23L33/10
CPCA61K31/365A61P3/06A61P9/10A61P9/00A61P25/20A61P9/06A61P13/12A61P1/14A61P1/10C07D307/58A23L33/10A23V2002/00A23V2200/3262A23V2200/326
Inventor 胡元会崔翰明师帅张秋燕宋庆桥吴华芹魏艺耿彦婷
Owner GUANGANMEN HOSPITAL CHINA ACAD OF CHINESE MEDICAL SCI
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