Treatment medicine of insomnia accompanied with anxiety and depression

A technique for treating anxiety and depression, and treating drugs, which is applied in drug combinations, medical preparations containing active ingredients, and pharmaceutical formulas, etc.

Active Publication Date: 2018-06-15
SHANXI PROVINCE CHINESE MEDICINE RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some antidepressant drugs such as amitriptyline, doxepin, nefazodone and mirtazadone can also improve sleep, but long-term use is prone to fatigue, dizziness, sleepiness and other adverse reactions

Method used

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  • Treatment medicine of insomnia accompanied with anxiety and depression
  • Treatment medicine of insomnia accompanied with anxiety and depression
  • Treatment medicine of insomnia accompanied with anxiety and depression

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Take Bupleurum 1kg, Scutellaria baicalensis 1kg, Codonopsis 1kg, Pinellia 0.9kg, Ginger 0.6kg, Jujube 1kg, Guizhi 1kg, Poria cocos 1kg, Rhubarb 0.5kg, Albizia Julibrissin 1.2kg, Raisin 1.2kg, Polygala 1kg, Oyster 3kg , magnetite 3kg, crush oysters and magnetite to the coarsest powder, mix with other raw materials, add water and decoct 3 times, each time with 150kg of water, decocting time 1.5h. Combine three decoctions, concentrate to a relative density of 1.08 at 68°C, add ethanol to make the alcohol content reach 30%, refrigerate and stand for 12 hours, centrifuge, take the supernatant, recover ethanol until there is no alcohol smell, continue to concentrate to a thick paste, and dry , crushed through an 80-mesh sieve to obtain dry cream powder.

[0039]Mix lactose and mannitol at a mass ratio of 3:1 to make auxiliary materials, then add dry cream powder according to the mass ratio of dry cream powder and auxiliary materials at a mass ratio of 1:0.9, and use 85% ethan...

Embodiment 2

[0041] Weigh 1.5kg of Bupleurum, 1.5kg of Scutellaria, 1.5kg of Codonopsis, 1.5kg of Pinellia, 1.2kg of Ginger, 1.5kg of Jujube, 1.5kg of Guizhi, 1.5kg of Poria, 1kg of Rhubarb, 1.8kg of Albizia Jubilata, and 1.8kg of Laifuzi , polygala 1.5kg, oyster 3.5kg, magnet 3.5kg, the oyster and magnet are crushed to the coarsest powder, mixed with other raw materials, decocted 3 times with 250kg of water each time, decocting time 1.5h. Combine three decoctions, concentrate to a relative density of 1.06 at 65°C, add ethanol to make the alcohol content reach 30%, refrigerate and stand for 12 hours, centrifuge, take the supernatant, recover ethanol until there is no alcohol smell, continue to concentrate to a thick paste, and dry , crushed through an 80-mesh sieve to obtain dry cream powder.

[0042] Using maltodextrin as an auxiliary material, it is mixed with the dry cream powder according to the mass ratio of dry cream powder and auxiliary material of 1:1.5, and granulated with 85% eth...

Embodiment 3

[0044] Weigh 0.8kg of Bupleurum, 0.8kg of Scutellaria, 0.8kg of Codonopsis, 0.7kg of Pinellia, 0.4kg of Ginger, 0.8kg of Jujube, 0.8kg of Guizhi, 0.8kg of Poria, 0.3kg of Rhubarb, 0.8kg of Albizia Julibrissin, 1kg of Laifuzi , polygala 0.8kg, oyster 2.8kg, magnetite 2.8kg, the oyster and magnetite were crushed to the coarsest powder, mixed with other raw materials, decocted 3 times with 120kg of water each time, decocting time 1.5h. Combine three decoctions, concentrate to a relative density of 1.03 at 69°C, add ethanol to make the alcohol content reach 30%, refrigerate and stand for 12 hours, centrifuge, take the supernatant, recover ethanol until there is no alcohol smell, continue to concentrate to a thick paste, and dry , crushed through an 80-mesh sieve to obtain dry cream powder.

[0045] Mix dry cream powder and soluble starch in a mass ratio of 1:1, and granulate with 85% ethanol as a wetting agent to obtain granules with uniform size and good fluidity.

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Abstract

The invention discloses a treatment medicine of insomnia accompanied with anxiety and depression. The treatment medicine is prepared from the following crude drugs in parts by weight: 5 to 15 parts ofradix bupleuri, 5 to 15 parts of radix scutellariae, 2 to 10 parts of radix et rhizoma rhei, 5 to 15 parts of radix codonopsis, 5 to 15 parts of rhizoma pinelliae, 3 to 12 parts of rhizoma zingiberisrecens, 5 to 15 parts of fructus jujubae, 5 to 15 parts of cassia twig, 5 to 15 parts of poria cocos, 25 to 35 parts of oyster, 25 to 35 parts of magnetite, 8 to 18 parts of cortex albiziae, 8 to 18parts of semen raphani and 5 to 15 parts of radix polygalae. The treatment medicine disclosed by the invention has the effects of regulating yin and yang, smoothening and eliminating depression and tranquillization with heavy prescription and is mainly used for treating imbalance between yin and yang, liver depression caused fire and insomnia accompanied with phlegm heat, which are caused by exogenous and internal injuries and emotional upset; the treatment medicine has a remarkable improvement effect on accompanied anxiety and depression symptoms.

Description

technical field [0001] The invention relates to a medicine for treating insomnia, in particular to a medicine for treating insomnia accompanied by anxiety and depression based on Chinese herbal raw materials. Background technique [0002] Insomnia is usually manifested as difficulty in falling asleep or poor sleep quality. It is a common physical and psychological disease, which has serious adverse effects on people's normal work and life, and may even induce or aggravate a variety of physical diseases. According to a study published by the World Health Organization in 2013, about 27% of people worldwide are suffering from insomnia, and insomnia patients are often accompanied by emotional disorders, especially symptoms such as depression, anxiety, irritability and tension. [0003] At present, Western medicine mainly uses benzodiazepines, non-benzodiazepines, melatonin and antidepressants to treat insomnia. Barbiturates are rarely used clinically because of their serious ad...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61P25/20A61K35/618A61K33/26
CPCA61K33/26A61K35/618A61K36/076A61K36/233A61K36/31A61K36/344A61K36/48A61K36/539A61K36/54A61K36/69A61K36/708A61K36/725A61K36/8888A61K36/9068A61K2236/331A61K2236/39A61K2300/00
Inventor 郝旭亮倪艳李宝玲刘聪许雯雯独家能
Owner SHANXI PROVINCE CHINESE MEDICINE RES INST
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