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Application of compound helicascolide A to preparation of anti-tumor medicines

A technology of anti-tumor drugs and compounds, applied in the field of biomedicine

Active Publication Date: 2018-06-22
东岱(济南)智能技术有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The compound helicascolide A involved in the present invention is obtained by separating and purifying the endophytic fungus Daldinia esc hscholzii (Daldinia esc hscholzii) A630 fermentation broth of patchouli, and its structural formula is shown in formula (I), which is disclosed in the literature "Tarma n K, Palm GJ, Porzel A, et al. Helicascolide C, a new lactone from an Indonesian marine algicolous strain of Daldinia eschscholzii (Xylariaceae, Ascomycota) [J]. Phytochem Lett, 20 12,5(1):83- 86", but so far, there is no report on the anti-tumor activity of the compound helicascolide A in domestic and foreign literature

Method used

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  • Application of compound helicascolide A to preparation of anti-tumor medicines
  • Application of compound helicascolide A to preparation of anti-tumor medicines
  • Application of compound helicascolide A to preparation of anti-tumor medicines

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Embodiment 1

[0017] The compound helicascolide A involved in the present invention is obtained by separating and purifying the endophytic fungus Daldinia eschscholzii (Daldinia eschscholzii) A630 fermentation broth of Patchouli, and its structural formula is shown in formula (I):

[0018]

[0019] The preparation method of described compound helicascolide A is specifically as follows:

[0020] Preparation of fermentation culture: insert activated Daldinia eschscholzii A630 strain into potato glucose liquid medium, 28°C, 120rpm, cultivate for 5 days to obtain seed liquid, and insert seed liquid into potato with an inoculum of 10% by volume In the glucose liquid medium, cultivated under the same conditions for 7 days to obtain the fermentation culture.

[0021] The fermentation broth and mycelium of the fermentation culture are separated, the fermentation broth is extracted with ethyl acetate, and the extract is concentrated by distillation to obtain an extract; the extract is passed thro...

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Abstract

The invention discloses application of a compound helicascolide A to preparation of anti-tumor medicines. The compound helicascolide A has quite strong cytotoxic activity for glioma cells SF-268, breast cancer cells MCF-7, large-cell lung cancer cells NCI-H460 and human liver cancer cells HepG-2. It is shown that the compound helicascolide A has good anti-tumor activity, and can be applied to preparation of the anti-tumor medicines. Thus, candidate medicines are provided for the research and development of new anti-tumor medicines, and the scientific basis is provided for the development and utilization of natural active substances from plant endophytic fungi.

Description

Technical field: [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of compound helicascolide A in the preparation of antitumor drugs. Background technique: [0002] Cancer is a frequently-occurring and common disease that seriously endangers human health. According to the statistics of the World Health Organization (WHO), 10 million people in the world suffer from cancer every year, and about 6 million people die from cancer. Moreover, the population is aging, the number of smokers is increasing, physical activity is decreasing, and the diet lacks vegetables and fruits. Bad habits may lead to a sharp increase in the number of cancers worldwide, which has seriously endangered human life and quality of life. Therefore, finding effective anticancer drugs is an important research topic in the world medical community. [0003] Endophytic fungi live in a special environment in plants for a long time, co-evolve with th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/366A61P35/00
CPCA61K31/366
Inventor 李浩华章卫民卢梦梦陈玉婵刘洪新
Owner 东岱(济南)智能技术有限公司
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