Content determination method for paeoniflorin and calycosin-7-glucoside in traditional Chinese medicine preparation

A technology of calycosin and glucoside, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problem that it is difficult to reflect the quality of raw materials, and achieve optimized solution preparation methods, high precision and recovery, repeatability and stability good sex effect

Inactive Publication Date: 2018-06-22
广西壮族自治区食品药品检验所
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  • Description
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AI Technical Summary

Problems solved by technology

There are as many as eleven medicinal materials in the prescription of Xiaokeling Tablets. The current standard can only reflect part of the situation of the medicinal materials, and it is difficult to reflect the pros and cons of the medicinal materials.

Method used

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  • Content determination method for paeoniflorin and calycosin-7-glucoside in traditional Chinese medicine preparation
  • Content determination method for paeoniflorin and calycosin-7-glucoside in traditional Chinese medicine preparation
  • Content determination method for paeoniflorin and calycosin-7-glucoside in traditional Chinese medicine preparation

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Embodiment 1

[0037] The content determination method of paeoniflorin and verbasil glucoside in Xiaokeling tablets and Xiaokeling capsules of traditional Chinese medicines includes the following:

[0038] Instruments and reagents:

[0039] Agilent 1260 high performance liquid chromatograph with DAD detector; ML204 electronic analytical balance (Mettler-Toledo Instruments Shanghai Co., Ltd.), Hei-VAP type rotary evaporator (German HeidoLph company).

[0040] Paeoniflorin (provided by China Institute for Food and Drug Control, batch number: 110736-201741, content 95.7%);

[0041] Mullins isoflavone glucoside (provided by China Institute for Food and Drug Control, batch number: 111920-201203, content 97.3%);

[0042] Acetonitrile and potassium dihydrogen phosphate reagents are chromatographically pure, and other reagents are analytically pure;

[0043] Xiaokeling tablets and Xiaokeling capsules are all samples tested by the national evaluation in 2017. Each sample contains paeoniflorin (C 23 H 28 O 11 ),...

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Abstract

The invention discloses a content determination method for paeoniflorin and calycosin-7-glucoside in a traditional Chinese medicine preparation. According to the method, the content of the paeoniflorin and the calycosin-7-glucoside in Xiaokeling tablets and Xiaokeling capsules is detected by adopting a high-performance liquid chromatography, and effective evidence is provided for inspecting whether enterprises have no material feeding or less material feeding and poor-quality medicinal material feeding behaviors or not. According to the content determination method, detection conditions are improved and a solution preparation method is optimized according to Volume Four 0512 of Pharmacopoeia of the People's Republic of China of 2015 Edition, so that the determination method is more efficient and more accurate and the determination method has specificity and no interference on negative control.

Description

Technical field [0001] The invention relates to a method for detecting traditional Chinese medicine preparations, in particular to a method for determining the contents of paeoniflorin and verbasil glucoside in Xiaokeling tablets and Xiaokeling capsules. Background technique [0002] Xiaokeling tablets are prepared by decocting five medicinal materials such as Rehmannia, Schisandra, Ophiopogon, Astragalus, and Lycium barbarum, and then mixed with the fine powder of Moutan Bark, Coptis, Poria, Red Ginseng, Trichosanthes, Gypsum, etc. It has the effect of nourishing yin, clearing heat and purging fire, producing body fluid and quenching thirst. It is clinically used for diabetes caused by deficiency of both qi and yin. The current standards of the drug mainly include the 2015 edition of the Chinese Pharmacopoeia and the State Food and Drug Administration standard YBZ06282004. In addition to traits and general provisions, the "Chinese Pharmacopoeia" includes microscopic and thin-la...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06
Inventor 罗轶张涛张颖婷林燕翔张慧黄博姚力朱雪妍
Owner 广西壮族自治区食品药品检验所
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