Folium Ginkgo extract and medical use thereof

A technology of ginkgo biloba and extracts, applied in the field of medicine, can solve the problems of being unable to take care of oneself, leaving disabilities, relatives and social burdens, etc., and achieve the effects of good anti-oxidation, good absorption and high bioavailability

Pending Publication Date: 2018-07-06
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although some patients survived after being rescued, most of them were left with disabiliti...

Method used

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  • Folium Ginkgo extract and medical use thereof
  • Folium Ginkgo extract and medical use thereof
  • Folium Ginkgo extract and medical use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] A. Extraction

[0044] Weigh 8kg of ginkgo leaves, carry out alcohol extraction with 20% ethanol solution at a ratio of 1:15 to the material-to-liquid ratio, extract twice by reflux, combine the extracts and concentrate to a density of 1.1-1.2.

[0045] B. Macroporous resin purification and extraction phase separation

[0046] The concentrated solution was coated with macroporous resin (D101), the column volume was 1 L / kg crude medicinal material, firstly eluted with water for 6 times the volume, then eluted with 60% ethanol for 8 times the volume, and collected the alcohol eluate. The eluate was concentrated to no alcohol, extracted with ethyl acetate at a ratio of 1:1, extracted three times in the same way, and the ester phases were combined to obtain an aqueous phase and an ester phase, respectively.

[0047] C. Purification of terpenoid lactones and removal of ginkgolic acid

[0048] The ethyl ester phase was concentrated and dried, dissolved in 50% ethanol, the v...

Embodiment 2

[0054] A. Extraction

[0055] Weigh 8 kg of Ginkgo biloba leaves, carry out alcohol extraction with 50% ethanol solution at a ratio of 1:15 to the material-to-liquid ratio, extract twice by reflux, combine the extracts and concentrate to a density of 1.1-1.2.

[0056] B. Macroporous resin purification and extraction phase separation

[0057] The concentrated solution was coated with macroporous resin (D101), the column volume was 1 L / kg crude medicinal material, firstly eluted with water for 6 times the volume, then eluted with 60% ethanol for 8 times the volume, and collected the alcohol eluate. The eluate was concentrated to no alcohol, extracted with ethyl acetate at a ratio of 1:0.2, extracted three times by the same method, and the ester phases were combined to obtain an aqueous phase and an ester phase, respectively.

[0058] C. Purification of terpenoid lactones and removal of ginkgolic acid

[0059] The ethyl ester phase was concentrated and dried, dissolved in 50% e...

Embodiment 3

[0065] A. Extraction

[0066] Weigh 8 kg of ginkgo leaves, carry out alcohol extraction with 70% ethanol solution at a ratio of material to liquid ratio of 1:10, extract twice by reflux, combine the extracts and concentrate to a density of 1.1-1.2.

[0067] B. Macroporous resin purification and extraction phase separation

[0068] The concentrated solution was coated with macroporous resin (AB-8), the column volume was 1 L / kg crude medicinal material, firstly eluted with water for 6 times the volume, then eluted with 60% ethanol for 8 times the volume, and collected the alcohol eluate. The eluate was concentrated to no alcohol, extracted with ethyl acetate at a ratio of 1:2, extracted three times by the same method, and the ester phases were combined to obtain an aqueous phase and an ester phase, respectively.

[0069] C. Purification of terpenoid lactones and removal of ginkgolic acid

[0070] The ethyl ester phase was concentrated and dried, dissolved in 50% ethanol, the v...

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PUM

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Abstract

The invention relates to a Folium Ginkgo extract and a medical use thereof. Concrete embodiments in the invention show that compared with existing Folium Ginkgo extracts, the Folium Ginkgo extract inthe invention has an obvious treatment effect on myocardial deficiency caused by pituitrin, can effectively avoid reperfusion injury of rats and significantly reduce the infarct size, and has a bettertreatment effect on cardiovascular diseases. A preparation technology of the Folium Ginkgo extract, further provided in the invention, has the advantages of high yield and stable quality in the obtained product, simple extraction process, suitableness for industrial large-scale production, and convenience in promotion and application of the Folium Ginkgo extract.

Description

technical field [0001] The invention relates to a ginkgo biloba extract and its medicinal use, belonging to the field of medicine. Background technique [0002] According to statistics, the prevalence, morbidity and mortality of cardiovascular and cerebrovascular diseases in my country have continued to rise over the past 30 years, jumping from the seventh in the 1960s to the first. There are 2.5 million people, accounting for 50% of the total case fatality rate of the population, which is slightly lower than that of industrialized developed countries. Although some patients survived after rescue, most of them were left disabled and could not take care of themselves, causing a serious burden to their relatives and society. Therefore, finding innovative drugs for cardiovascular and cerebrovascular diseases has always been a hot spot in the medical field. Among the many drugs for treating cardiovascular diseases, finding an effective drug with definite curative effect and low...

Claims

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Application Information

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IPC IPC(8): A61K36/16A61P9/10A61K127/00
CPCA61K36/16A61K2236/333A61K2236/39A61K2236/51A61K2236/55
Inventor 张贵民姚景春梁红宝
Owner LUNAN PHARMA GROUP CORPORATION
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