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Application of protodioscin in the preparation of anti-drug-resistant osteosarcoma drugs

A technology of protodioscin and drug resistance is applied in the application field of protodioscin in the preparation of drug-resistant bone tumor drugs, can solve the problems of poor treatment effect of drug-resistant osteosarcoma and the like, and achieve the effect of broad application prospects

Active Publication Date: 2020-05-19
THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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Problems solved by technology

[0011] Aiming at the defect that existing drugs (including diosgenin) have poor therapeutic effects on drug-resistant osteosarcoma, the object of the present invention is to provide the application of protodiosgenin in the preparation of drug-resistant bone tumor drugs

Method used

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  • Application of protodioscin in the preparation of anti-drug-resistant osteosarcoma drugs
  • Application of protodioscin in the preparation of anti-drug-resistant osteosarcoma drugs
  • Application of protodioscin in the preparation of anti-drug-resistant osteosarcoma drugs

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Embodiment

[0035] Application of Protodioscin in Inhibiting Osteosarcoma Cell Proliferation and Inducing Osteosarcoma Cell Apoptosis

[0036] The human osteosarcoma U2OS, HOS, MNNGHOS, 143B, MG63, SJSA1, G292 cell lines used in the present invention were purchased from the Shanghai Cell Bank of the Chinese Academy of Sciences; The primary human osteosarcoma cell line constructed by the Department of Bone Oncology, the First Affiliated Hospital of the University; protodioscin was purchased from Guangzhou Anbang Biotechnology Co., Ltd., and Hoechst 33258 was purchased from American Thermo Company; DMEM high-glucose medium and fetal bovine serum were purchased from Invitrogen Company; MTT kit was purchased from Sigma Company. Nude mice were purchased from Nanjing University-Nanjing Institute of Biomedicine.

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Abstract

The invention discloses application of dioscin in preparing a drug-resistant osteosarcoma medicine. Drug-resistant osteosarcoma refers to an osteosarcoma cell line which has drug resistance to commonanti-tumor medicines, particularly U2OS tumor cells with drug resistance to methotrexate, doxorubicin and cis-platinum. Moreover, as a natural plant extract medicine, dioscin has wide application prospects in the field of anti-tumor medicine treatment.

Description

technical field [0001] The invention belongs to the field of medicaments, and in particular relates to the application of protodioscin in the preparation of drug-resistant bone tumor medicaments. Background technique [0002] Primary osteosarcoma is a common malignant bone tumor with onset mainly in adolescence. Because of its insidious onset and rapid progress, it is mostly in the middle and late stages when it is discovered. Therefore, the effect of surgery is poor, and radiotherapy and chemotherapy have obvious adverse reactions, resulting in poor quality of life and short survival period of osteosarcoma patients. There is an urgent need for effective and safe anticancer drugs for the treatment of osteosarcoma. [0003] Under normal physiological conditions, cell proliferation is strictly regulated, and cells can metabolize through programmed death, that is, apoptosis. However, when related molecular events such as activation of oncogenes, inactivation of tumor suppres...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61P35/00A61P19/00
CPCA61K31/7048
Inventor 沈靖南尹军强贾强刘伟海黄纲邹昌业谢显彪林熙武征赵巨鹏
Owner THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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