A kind of anticancer drug composition

A composition and drug technology, applied in the field of anticancer drug compositions, can solve the problems of increasing the utilization cost of SN-38 drugs, complicated processes, etc., and achieve the effects of increasing the anticancer effect, simple ball milling process, and improved solubility

Active Publication Date: 2021-05-04
ZHEJIANG UNIV OF TECH
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Problems solved by technology

[0007] Although the above prior art has achieved the technical effect of increasing the solubility of SN-38, the process is relatively complicated, which increases the cost of SN-38 drug utilization

Method used

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  • A kind of anticancer drug composition

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preparation example Construction

[0024] (1) Preparation of anticancer drug composition and comparative example:

[0025] 1. Preparation of anticancer drug composition:

[0026] (1) Raw material preparation: take 100mg of 7-ethyl-10-hydroxycamptothecin and 10g of sodium glycyrrhetinate in the dark;

[0027] (2) Roller ball mill: Prepare 20 small steel balls of 4mm, 8mm, and 12mm each, put the raw materials and small steel balls into the drum and mix well, tighten the cover, set the speed at 20rpm, temperature at 25°C, and rotate for 24h.

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Abstract

The invention discloses an anticancer drug composition, which is characterized in that it consists of 7-ethyl-10-hydroxycamptothecin and sodium glycyrrhetinate, which is prepared by the following method: (1) Raw material preparation: avoid light Weigh 7-ethyl-10-hydroxycamptothecin and sodium glycyrrhetinate; (2) roller milling: carry out roller milling with 7-ethyl-10-hydroxycamptothecin and sodium glycyrrhetinate, and the milling speed is 10- 30rpm, temperature 20-30℃, ball milling time 12-36h. The anticancer drug composition of the invention has simple preparation process, no pollution to the environment, is suitable for large-scale production, and significantly improves the solubility of 7-ethyl-10-hydroxycamptothecin, and has good anticancer effect.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to an anticancer drug composition. Background technique [0002] 7-ethyl-10-hydroxycamptothecin (7-ethyl-10-hydroxycamptothecin, SN-38), is the biologically active metabolite of irinotecan hydrochloride (CPT-11). CPT-11 is an inactive prodrug, which is converted into an active metabolite SN-38 by carboxylesterase (CES) in plasma, small intestinal mucosa and liver in vivo. In 2000, FDA approved irinotecan as an anticancer drug for advanced colon cancer. First-line treatment drugs. But in fact, the anti-tumor activity of SN-38 is 100-1000 times that of CPT-11. After intravenous or oral administration of CPT-11, only a small part of CPT-11 is converted into SN-38, and the difference between different patients very big. The direct use of the active metabolite SN-38 of CPT-11 is mainly limited by its solubility. SN-38 is almost insoluble in water (1-3μg / ml), and insoluble in...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/56A61P35/00A61K31/4745
CPCA61K31/4745A61K31/56A61K2300/00
Inventor 孙漩嵘祝大部
Owner ZHEJIANG UNIV OF TECH
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