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Bos taurus domesticus gmelin ICP-MS identification method and application

A technology of ICP-MS and SIMCA-P14.1, which is applied in the field of kidney sperm ICP-MS identification, can solve the problems of uneven quality, lack of effective and reliable quality monitoring methods, unfavorable quality control of medicinal materials, etc., and achieve the effect of simple and fast method

Active Publication Date: 2018-08-24
SHANXI PROVINCE FOOD & DRUG INSPECTION INST
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to literature records, kidney sperm has the effect of promoting water and reducing swelling, and it is used in clinical medicine to treat "diarrhea". Professor Yinhuihe's "Shugan Sanjie Prescription" mentioned that the use of kidney sperm single herbal medicine also has a miraculous effect, but at present There is no quality standard for kidney sperm, the market of kidney sperm medicinal materials is chaotic, good and bad are mixed, and there is a lack of effective and reliable quality monitoring methods, which is not conducive to the quality control of medicinal materials
There is no effective identification method and monitoring method for the uniform stability of different batches of kidney sperm and the species source of kidney sperm

Method used

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  • Bos taurus domesticus gmelin ICP-MS identification method and application
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  • Bos taurus domesticus gmelin ICP-MS identification method and application

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Embodiment 1

[0026] The construction process of the kidney sperm ICP-MS identification method of the present invention.

[0027] A total of 12 batches of kidney sperm of 2 different varieties were collected from the market (6 batches for each variety, of which 1-6 were bovine (N); 7-12 were pig-derived (Z))

[0028] 1. Determination of the inorganic element spectrum of 12 batches of kidney sperm of the above-mentioned different varieties.

[0029] (1) Precisely weigh 0.1g of the above-mentioned kidney sperm powder into a beaker, add 10 mL of 65% nitric acid and 1 mL of perchloric acid respectively, cover the glass dish and let it stand overnight, then place it on an electric heating plate for wet digestion at 180°C until it reaches liquid After clarification and transparency, rinse the acid on the electric heating plate until about 1mL of liquid remains, add ultrapure water to dilute to a 50mL colorimetric tube.

[0030] (2) Before the test, the sample was diluted 20 times, and tested wit...

Embodiment 2

[0038] A method for identifying kidney sperm ICP-MS, comprising the following steps:

[0039] (1) Perform wet digestion on the samples of known basic kidney sperm and different batches of kidney sperm to be tested: accurately weigh 0.1 g into a beaker, add 10mL of 65% nitric acid and 1mL of perchloric acid respectively, cover the glass dish and let it stand overnight, then put it on the electric heating plate for wet digestion at 180°C, digest until the liquid is clear and transparent, then rinse the acid on the electric heating plate until the liquid remains 1mL , add ultrapure water to make up to 50mL colorimetric tube.

[0040](2) Dilute the above-mentioned known basic kidney sperm and different batches of kidney sperm to be tested and dilute them 20 times for ICP-MS measurement to obtain Li, Na, Mg, Al, P, S, K, Ca, Ti , V , Mn , Co , Ni , Cu, Zn, In, Ba, U, a total of 18 elements; the specific measurement conditions are to adjust the sensitivity of the instrument before ...

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Abstract

The invention relates to an identification method of animal calculus type traditional Chinese medicines, and specifically relates to a bos taurus domesticus gmelin ICP-MS identification method and application. The method comprises the following steps: performing wet digestion on known basic original bos taurus domesticus gmelin and different batches of bos taurus domesticus gmelin samples; performing ICP-MS detection to obtain data of 18 elements, including Li, Na, Mg, Al, P, S, K, Ca, Ti, V, Mn, Co, Ni, Cu, Zn, In, Ba and U; importing the detected data to SPSS 22.0 software; and carrying outclustering analysis. According to the method, a 'group-to-group connection' clustering method is carried out to form a tree-like clustering map through which whether the bos taurus domesticus gmelin to be detected belongs to the same species as the known basic original bos taurus domesticus gmelin; or the data are imported to the SIMCA-P 14.1 software, and PCA analyzing is carried out to obtain aPCA scatter diagram, and meanwhile, the uniform stability of the bos taurus domesticus gmelin of different batches and to be detected can be determined based on the gathering degree in the scatter diagram. Therefore, the species origin of the bos taurus domesticus gmelin is identified based on inorganic element; the uniform stability of the bos taurus domesticus gmelin at different batches can beidentified. The method is simple and quick.

Description

technical field [0001] The invention relates to an identification method of traditional Chinese medicine for calculi in animals, in particular to an ICP-MS identification method and application of kidney sperm. Background technique [0002] The quality uniformity of traditional Chinese medicine preparations has always been a hot issue. The quality uniformity of traditional Chinese medicine preparations directly affects the safety and effectiveness of clinical medication, and is also related to the health and safety of patients. However, there are many factors that affect the uniform quality of traditional Chinese medicine preparations. Among them, the diversification of sources of Chinese medicinal materials, "one drug with multiple bases" and the uniformity and stability of different batches of Chinese medicinal materials will all affect the quality of traditional Chinese medicine prepared using them as raw materials. The uniformity of the formulation is affected. [0003]...

Claims

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Application Information

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IPC IPC(8): G01N21/73
CPCG01N21/73
Inventor 赵思俊王春芳崔宇红罗晋萍郭景文张蕻刘馨曲萍
Owner SHANXI PROVINCE FOOD & DRUG INSPECTION INST
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