Drug for promoting function recovery of rat spinal cord injuries, and animal model thereof

Abstract

The invention belongs to the technical fields of stem cells and organic chemistry, and discloses a drug for promoting the function recovery of rat spinal cord injuries, and an animal model thereof. Different doses of methylprednisolone, utilization of anti-inflammatory and anti-apoptotic neuroprotective effects and transplantation of amnion derived neural stem cells at different times after operation are combined, and whether the combination of the drug and the animal model can promote axonal regeneration and function recovery after experiment rat spinal cord injuries or not, so the drug explores a new therapeutic strategy for SCI repairing, and has great theoretical significance and broad clinical application prospect. Cell transplantation is combined; the neuroprotective effect of methylprednisolone and the nerve repairing effect of HAM-NSCs are combined to explore a new strategy for SCI treatment; the drug provides a theoretical basis for exploring the recovery mechanism of nerve injuries, and provides a feasible scheme for clinical treatment of the spinal cord injuries; and the drug effectively reduces the disability rate of SCI, improves the living quality of patients with thespinal cord injuries, and has broad clinical application values.

Description

technical field [0001] The invention belongs to the technical field of stem cells and organic chemistry, and in particular relates to a medicine and an animal model for promoting the recovery of spinal cord injury function in rats. Background technique [0002] At present, the existing technologies commonly used in the industry are as follows: Spinal cord injury (SCI) is a serious injury to the central nervous system. Since the spinal cord is the intermediary pathway of many nerve functions, SCI and its secondary pathophysiological reactions can directly lead to nerve function damage, thereby causing tissue and organ dysfunction. The morbidity and mortality rates are very high. SCI is one of the difficult diseases recognized in the world. It has the characteristics of high incidence, high disability rate, high consumption and low mortality. It seriously threatens human health, affects people's quality of life, and brings heavy burdens to society and families. Burden, how t...

AI Technical Summary

Problems solved by technology

[0003] In summary, the problems in the prior art are: Spinal cord injury (SCI) repair is a worldwide problem

MPs mainly play a neuroprotective role in the CNS, while NSCs mainly play a neurorestorative role? So, what are the effects of different doses of MP on NSCs? Can MP promote the survival of transplanted NSCs, and whether MP and NSCs have a synergistic therapeutic effect? Literature search found that there is little research in this area, and the research is of great significance

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