Composition and application thereof to prevention and control avian infectious laryngotracheitis

A composition and a technology of sexual larynx, applied in the field of veterinary medicine, can solve the problems of declining growth rate and egg production rate of chickens, endangering human food safety, serious drug residues, etc. Effect

Inactive Publication Date: 2018-10-09
绵阳市农业科学研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This type of drug has a single target. Although it can achieve certain curative effect, its many disadvantages are becoming more and more obvious. For example, it is easy to produce drug resistan

Method used

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  • Composition and application thereof to prevention and control avian infectious laryngotracheitis
  • Composition and application thereof to prevention and control avian infectious laryngotracheitis
  • Composition and application thereof to prevention and control avian infectious laryngotracheitis

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preparation example Construction

[0042] Further, the preparation method of the total flavonoids of shegan comprises:

[0043] Soak the dried medicinal material in a weak alkaline aqueous solution with a pH of 8-9, and extract with ultrasonic vibration to obtain a crude extract, then adjust the pH of the crude extract to 3-5, obtain a precipitate after standing, and dry to obtain a crude extract;

[0044] Then dissolve the crude extract of Shegan in water, and extract it with petroleum ether, chloroform, ethyl acetate and n-butanol in sequence, and the obtained ethyl acetate extract is the total flavonoids of Shegan.

[0045] Preferably, during extraction, the frequency of ultrasonic vibration extraction is 3000-5000 Hz, and the time of ultrasonic vibration extraction is 15-28 min.

[0046] In some embodiments, the amount of total flavonoids in the composition of the present invention can be 1-300 parts by weight, such as 2-250 parts by weight, or 10-200 parts by weight, or 15-150 parts by weight, or 20-100 pa...

Embodiment 1

[0054] 1. Test animals

[0055] Healthy commercial Hy-Line gray chickens were selected and adapted to the laboratory for a week before the experiment. The temperature in the laboratory was kept at 23-27°C, and they had free access to water and food.

[0056] 2. Experiment setting and grouping

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Abstract

The invention provides a composition and application thereof to prevention and control avian infectious laryngotracheitis and relates to the field of veterinary drugs. The composition is prepared fromlacidipine and daclatasvir. According to the composition, two active components including the lacidipine and the daclatasvir are compounded, so that the composition has a strong killing effect on avian infectious laryngotracheitis viruses, and can be used for inhibiting the spreading of the avian infectious laryngotracheitis viruses and effectively reducing the death rate of infected poultry; thedrug resistance is not easy to generate; the composition has the characteristics of rapid effect and excellent curative effect.

Description

technical field [0001] The invention relates to the field of veterinary medicine, in particular to a composition and its application for preventing and treating chicken infectious laryngotracheitis. Background technique [0002] Infectious laryngotracheitis (ILT) is an acute, febrile, highly contagious upper respiratory infectious disease of chickens caused by infectious laryngotracheitis virus (ILTV). Difficulty, coughing up bloody mucus, edema and hemorrhage of the tracheal mucosa, etc., and cause the death of infected chickens and the decline in egg production of laying hens, causing serious economic losses to the chicken industry. [0003] At present, in the treatment of this disease, antiviral drugs such as ribavirin, amantadine and morpholinidine are mainly used. This type of drug has a single target. Although it can achieve certain curative effect, its many disadvantages are becoming more and more obvious. For example, it is easy to produce drug resistance, which wil...

Claims

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Application Information

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IPC IPC(8): A61K31/4422A61K31/4178A61K36/88A61P11/00A61P31/20A23K50/75A23K10/30A23K20/137A23K20/132A61K31/216
CPCA61K31/4422A23K10/30A23K20/132A23K20/137A23K50/75A61K31/216A61K31/4178A61K36/88A61P11/00A61P31/20A61K2300/00
Inventor 王育伟康润敏岳华王志胜
Owner 绵阳市农业科学研究院
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