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Daclatasvir is used with another antiviral medication (sofosbuvir) to treat chronic (long-lasting) hepatitis C, a viral infection of the liver. Daclatasvir should never be used without sofosbuvir. Daclatasvir and sofosbuvir may also be used with another antiviral medication (ribavirin).
A method for synthesizing daclatasvir hydrochloride
The application discloses a synthesis method of daclatasvir hydrochloride. The daclatasvir hydrochloride is obtained from biphenyl as a starting material through a Friedel-Crafts acylation reaction, a condensation cyclization reaction, an amide hydrolysis reaction, a condensation reaction, salt formation and the like. The synthesis method has the advantages of low synthesis cost, simple post-treatment method, high yield, industrial production, reduced solvent and catalyst use, reduced reaction by-products and pollution, conformity to the development trend of green chemistry, maximized reduction of the production cost of the overall process and high application value.
Owner:ANHUI UNIV