Novel method for synthesizing daclatasvir intermediate

A cyclization and compound technology, which is applied in the field of preparation of daclatasvir intermediates, can solve the problems of rising raw material costs, many steps, and poor safety
CN105153128AInactive Publication Date: 2015-12-16SHANGHAI FOREFRONT PHARMA CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI FOREFRONT PHARMA CO LTD
Publication Date
2015-12-16
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a novel method for synthesizing a daclatasvir intermediate, particularly a preparation method of a compound disclosed as Formula 1. The method uses biphenyl and halogen acyl bromide as initial raw materials, and avoids using high-cost reaction raw materials. Thus, the preparation method is simple and safe, and is suitable for industrial production.
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Description

technical field

[0001] The invention relates to the field of preparation of pharmaceutical intermediates, specifically, the invention provides a method for preparing a daclatasvir intermediate. Background technique

[0002] Daclatasvir (Daclatasvir) is a hepatitis C treatment drug developed by BMSquibb, which has been marketed in the United States, Europe and Japan respectively. The clinical cure rate of hepatitis C in combination with Sofosbuvir (Sofosbuvir) can be greater than 90%. , has been included in the list of the most important essential therapeutic drugs by WHO, and has good therapeutic effects and market prospects.

[0003] In the method for preparing Daclatasvir (Daclatasvir) known in the art at present, the compound of formula I is the most important and most economical intermediate, so in order to industrialize the production of Daclatasvir, this field needs a kind of compound that can efficiently synthesize A method for a compound of formula I.

[0004] ...

Claims

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