37 results about "Potassium hexafluorophosphate" patented technology

The invention provides a method for detecting nitrosamine impurities in a starting material N-Boc-piperazine of tandospirone citrate, which comprises the following steps: carrying out linear gradient elution on a chromatographic column by taking octadecylsilane chemically bonded silica as a filler, a potassium hexafluorophosphate solution as a mobile phase A and acetonitrile as a mobile phase B; the pH value of the potassium hexafluorophosphate solution ranges from 4.3 to 5.5. The method is high in specificity, high in detection sensitivity and accuracy and good in linearity, and the nitrosamine impurity 1-nitrosopiperazine contained in N-Boc-piperazine can be accurately measured. According to the method, the technical barrier of detecting the nitrosamine impurities by using a gas chromatography-mass spectrometry or liquid chromatography-mass spectrometry method at present is overcome, the detection cost is reduced, and meanwhile, other impurities contained in the method do not influence the accurate detection of the nitrosamine impurities.

The invention discloses a high-temperature-resistant adhesive tape and a preparation method thereof, and belongs to the technical field of adhesive tape preparation. The adhesive tape is composed of a composite adhesive and a composite polyester film, and the composite adhesive is composed of hydroxyl polydimethylsiloxane, boric acid, 2, 2-bis [4-(4-aminophenoxy) phenyl] propane and 4, 4-bis (4-aminophenoxy) phenyl] propane. The composite polyester film is prepared from polyethylene glycol terephthalate, 1-allylimidazole, 2-bromobutane, potassium hexafluorophosphate, methacryloyloxyethyl trimethyl ammonium chloride and nano silicon dioxide, and the composite polyester film is prepared from polyethylene glycol terephthalate, 1-allylimidazole, 2-bromobutane, potassium hexafluorophosphate, methacryloyloxyethyl trimethyl ammonium chloride and nano silicon dioxide. The adhesive tape prepared by the method has excellent viscosity, high temperature resistance, aging resistance and antistatic property.

The invention discloses an antistatic PET dust-free film and a preparation method thereof, and relates to the technical field of high polymer materials. When the antistatic PET dust-free film is prepared, firstly, 6-bromohexanoic acid reacts with 4-imidazole-1-butyric acid, and then is subjected to ion exchange with potassium hexafluorophosphate to prepare diacid imidazole hexafluorophosphate ionic liquid; the preparation method comprises the following steps: enabling montmorillonite to react with tetraethoxysilane, 3-aminopropyltriethoxysilane and dodecyl triethoxysilane, so as to obtain modified montmorillonite; carrying out copolycondensation on terephthalic acid, the diacid imidazole hexafluorophosphate ionic liquid, ethylene glycol and the modified montmorillonite to prepare a modified polyester master batch; and carrying out melt blending on the modified polyester master batch and a chain extender, and carrying out blow molding to obtain the antistatic PET dust-free film. The prepared antistatic PET dust-free film has the advantages of being antistatic, flame-retardant, super-hydrophobic and low in dust adhesion rate.

The invention provides a lithium hexafluorophosphate preparation method, which comprises: 1, adding a molecular sieve into an acetonitrile solvent, uniformly shaking, and standing; step 2, filtering the mixture after standing to obtain a treated acetonitrile solvent, and regenerating and recycling the filtered molecular sieve; 3, preparing the dried potassium hexafluorophosphate and the treated acetonitrile solvent, and putting the mixture into a container; 4, stirring the solution in the container, adding lithium hydride in a stirring state, and introducing ammonia gas to carry out catalytic reaction until the reaction is finished; 5, filtering the reactant in the step 4, carrying out reduced pressure distillation on the filtrate, recovering part of the solvent, and carrying out cooling crystallization to obtain a complex of lithium hexafluorophosphate and acetonitrile; and step 6, filtering the complex in the step 5, and carrying out vacuum drying to obtain the lithium hexafluorophosphate. The method provides a green process for preparing the lithium hexafluorophosphate, which integrates safety, economy and environmental protection.

The invention discloses a method for determining bedaquiline fumarate clean verification target residues, and relates to the technical field of instrument analysis of chemical pharmacy. The method comprises the following steps: preparing a sample wiping solution; determining the content of bedaquiline fumarate in the sample wiping solution by adopting a liquid chromatography; chromatographic conditions are as follows: a chromatographic column is a VP-ODS C18 column; mobile phases: a potassium hexafluorophosphate aqueous solution and acetonitrile, wherein the concentration of the potassium hexafluorophosphate aqueous solution is 0.01-0.03 mol / L; the elution mode is isocratic elution; the flow rate is 1 ml / min to 2 ml / min; the column temperature is 28-32 DEG C; the method has good specificity and sensitivity for determination of bedaquiline fumarate cleaning verification target residues, is simple and convenient to operate, rapid in determination, simple and easy to implement, and overcomes the defects that TOC, chemical titration methods, conductivity methods, pH methods and the like which are commonly used at present do not have specificity.

The invention discloses a method for synthesizing a 1-aminoindole derivative through electrooxidation cyclization, which comprises the following steps: adding an acetyl phenylhydrazine derivative, an alkyne derivative, [Cp * RhCl2] 2, sodium acetate, potassium hexafluorophosphate, t-BuOH and distilled water into a container filled with magnetons to obtain a mixed reaction solution; placing the mixed reaction liquid in a sand bath preheated to a preset temperature, taking a carbon rod as an anode and a platinum sheet as a cathode, inserting one ends of the cathode and the anode into the mixed reaction liquid at intervals, and connecting the other ends of the cathode and the anode to an electrochemical workstation to construct an electrooxidation cyclization system; and electrifying the electrochemical workstation to react for a preset time, so as to prepare the 1-aminoindole derivative. The method provided by the invention takes flowing electrons as an oxidant to replace an external oxidant, realizes regeneration internal circulation of the catalyst through driving of an electrochemical workstation, does not need the external oxidant, and is mild in reaction condition, simple in synthesis step and relatively short in reaction time.

The invention belongs to the technical field of pharmaceutical analysis, and particularly relates to a method for separating and determining nafamostat mesylate SM2 and related impurities thereof. The method is a high performance liquid chromatography, and comprises the following steps: by taking octadecylsilane chemically bonded silica as a chromatographic column filler, a potassium hexafluorophosphate solution as a mobile phase A and acetonitrile as a mobile phase B, separating nafamostat mesylate SM2 and related impurities thereof through linear gradient elution; and detecting by using detection wavelengths of 200 nm to 240 nm and 250 nm to 280 nm to obtain a chromatogram, so that effective determination of the nafamostat mesylate SM2 and the related impurities thereof is realized. The method provided by the invention adopts common buffer salt as a mobile phase, and has the characteristics of short analysis time, strong specificity, high sensitivity and good reproducibility.

The invention discloses a zinc ion battery negative electrode, a preparation method thereof and a zinc ion battery. The zinc ion battery negative electrode is obtained by performing heat treatment on zinc foil in a modifier, the modifier is any one or a combination of at least two of ammonium hexafluorosilicate, ammonium hexafluorophosphate, ammonium fluoride, potassium hexafluorosilicate, sodium hexafluorosilicate, sodium hexafluorophosphate and potassium hexafluorophosphate; the heat treatment temperature is 60-80 DEG C. The modifier can form a protective layer on the surface of the zinc foil, corrosion can be inhibited, zinc ion transmission and deposition can be regulated and controlled, and the electrochemical performance of the zinc ion battery can be remarkably improved. And the prepared zinc ion battery has excellent cycle life, long cycle stability and high specific discharge capacity.

The invention relates to a process for recovering an electrolyte and co-producing potassium hexafluorophosphate, which comprises the following steps: 1) taking the electrolyte, adding potassium fluoride and potassium carbonate solid, stirring for 0.5-1.5 hours at room temperature, and then stirring for 4-6 hours at 40-50 DEG C; 2) after stirring is finished, carrying out solid-liquid separation, and recovering the solvent from the obtained filtrate in a rectification manner; 3) performing solid-liquid separation to obtain a solid, adding acetonitrile, and stirring at 20-25 DEG C for 30-60 minutes; 4) after stirring, filtering and washing to obtain a lithium fluoride solid; and carrying out rotary evaporation on the obtained filtrate at 60-70 DEG C to obtain a crude potassium hexafluorophosphate solid. According to the process, a step-by-step extraction and hydrolysis process route is adopted, operation is easy, industrial production is easy to achieve, energy consumption and cost are reduced, and the potassium hexafluorophosphate solid is produced while the electrolyte is recycled; and guidance is provided for electrolyte recovery and potassium hexafluorophosphate synthesis in the future.

The invention relates to the technical field of pharmaceutical analysis, in particular to a method for detecting related substances of a levodropropizine oral solution. According to the method, high performance liquid chromatography is adopted for detection, an octyl bond and a silica gel chromatographic column are selected, a mobile phase A and a mobile phase B are used for gradient elution, the flow velocity is 0.9-1.1 ml / min, the column temperature is 25-35 DEG C, and the detection wavelength is 252-256 nm; the mobile phase A is a 0.03 mol / L potassium hexafluorophosphate solution (containing 0.1% of phosphoric acid); the mobile phase A is methanol, the mobile phase B is methanol, the mobile phase A and the mobile phase B are used for gradient elution, and the time (min) / mobile phase B (v%) is 0 / 14; 15 / 14; 30 / 45; 50 / 60; 50.1 / 14; 60 / 14. The method can be used for effectively detecting the related substances of the levodropropizine oral solution, has the advantages of strong specificity and good accuracy, and can effectively guarantee the quality of the levodropropizine oral solution.

The invention provides a six-membered ring ether-based electrolyte, a preparation method, application and a potassium ion battery, and relates to the field of potassium ion batteries, the six-membered ring ether-based electrolyte comprises an electrolyte potassium salt and an electrolyte solvent, wherein the electrolyte potassium salt comprises one or more of potassium hexafluorophosphate, potassium tetrafluoroborate, potassium bis (fluorosulfonyl) imide, potassium trifluoromethanesulfonate, potassium bis (trifluoromethanesulfonyl) imide, potassium nitrate and potassium perchlorate; according to the electrolyte, the problem that the existing potassium ion battery electrolyte cannot be kept stable and continuously decomposed at high voltage and low voltage at the same time is solved, so that the cycling stability of the potassium ion battery is improved, and the potassium ion battery capable of keeping high energy density, high capacity retention rate and long cycle life is prepared.

The invention provides a method for separating and determining related substances of a remegapam intermediate by using HPLC (High Performance Liquid Chromatography), which comprises the following steps: carrying out gradient elution by using octadecylsilane chemically bonded silica as a chromatographic column filler, 0.01 mol / L potassium hexafluorophosphate solution as a mobile phase A and a solution obtained by uniformly mixing methanol and acetonitrile according to a volume ratio of (55-65): (35-45) as a mobile phase B at the flow velocity of 0.8-1.2 ml / min and the column temperature of 25-40 DEG C, the method comprises the following steps: detecting related substances of the remegapam intermediate by adopting an ultraviolet detector, wherein the detection wavelength of the ultraviolet detector is 260-270nm; the related substances of the remegapam intermediate are one or more of an impurity I, an impurity II and an impurity III. According to the present invention, the impurity I, the impurity II and the impurity III in the remegapam intermediate can be rapidly and efficiently separated under the same chromatographic condition so as to effectively control the quality of the bulk drug, and the detection method has advantages of rapidness, simpleness, convenience, high sensitivity, strong specificity, high precision, accuracy, reliability and convenient operation.

The invention belongs to the technical field of pharmaceutical analysis, and particularly relates to a method for separating, identifying and quantifying nafamostat mesylate Z1 and impurities thereof. And the nafamostat mesylate Z1 is 6-cyano-2-naphthol. According to the method, octadecylsilane chemically bonded silica is adopted as a chromatographic column filler, a potassium hexafluorophosphate solution is adopted as a mobile phase A, acetonitrile is adopted as a mobile phase B, an impurity Z1b, an impurity Z1c, nafamostat mesylate Z1, an impurity Z1h, an impurity Z1a, an impurity Z1g, an impurity Z1d, an impurity SM1, an impurity SM1i, an impurity Z1f and / or an impurity SM1j are sequentially separated through linear gradient elution, and the separated impurities enter a detector for detection; and finally, calculating the content of each impurity by adopting a correction factor-added principal component self-contrast method. The method can effectively separate 6-cyano-2-naphthol and related impurities thereof within 60 minutes, and has the advantages of high sensitivity, strong specificity, good durability and simplicity and feasibility in operation.

The invention relates to an ortho-carborane-containing electrical stimulation response type iridium (III) complex and a preparation method and application thereof, the structural formula of the complex is shown as follows: the preparation method comprises the following steps: firstly, carrying out primary reaction on brominated 1-phenylpyridine, trimethylsilylacetylene, tetrakis (triphenylmethyl phosphine) palladium, cuprous iodide and triphenylphosphine, taking a solid-phase reaction product, and carrying out secondary reaction on the solid-phase reaction product to obtain the ortho-carborane-containing electrical stimulation response type iridium (III) complex. The preparation method comprises the following steps: carrying out a primary reaction on 2, 4-dimethyl-2-(2-chlorophenyl)-1, 2, 4-trimethyl-1, 3-pentanedione, mixing with potassium hydroxide, alcohol and tetrahydrofuran, carrying out a secondary reaction, carrying out a reflux reaction on a reaction product and a dodecahydrodecaboron bis (diethyl sulfide) complex in an organic solvent, carrying out a primary reaction on the reaction product and IrCl3, and carrying out a secondary reaction with an auxiliary ligand and potassium hexafluorophosphate to obtain the complex. Compared with the prior art, the iridium complex obtained after ortho-carborane is introduced to different sites of the ligand has good chemical and thermal stability and has good application prospects in information encryption, biomedical imaging, sensors and detection technologies.

The invention belongs to the technical field of pharmaceutical analysis, and particularly relates to an HPLC (High Performance Liquid Chromatography) method for separating and determining nafamostat mesylate X1 and impurities thereof. The impurities comprise an impurity NAA-SM2, an impurity NAA-SM2a, an impurity NAA-SM2f, an impurity NAA-X1d, an impurity NAA-X1b, an impurity NAA-X1e, an impurity NAA-X1f and isopropyl p-aminobenzoate. According to the method, octadecyl silane bonded silica gel is adopted as a chromatographic column filler, a potassium hexafluorophosphate solution is adopted as a mobile phase A, acetonitrile is adopted as a mobile phase B, and nafamostat mesylate X1 and impurities thereof are separated through linear gradient elution; and then calculating the content of each impurity by adopting an external standard method and / or a principal component self-contrast method multiplied by a correction factor according to a chromatogram. The method has the characteristics of good separation degree, good durability, high sensitivity and good reproducibility.

The present invention provides a metal iridium complex, a preparation method thereof and an application thereof, belonging to the technical field of compounds. The structural formula of the metal iridium complex is shown in Formula 1. The method is to first heat and reflux IrCl3·3H2O and (4-(2-pyridyl)benzaldehyde) to obtain (4-(2-pyridyl)benzaldehyde iridium dichloro bridge [Ir(pba)2Cl2]2; then place it and 4,7-dihydroxy-1,10-phenanthroline in the presence of a solvent in the dark and carry out a reflux reaction. After the reaction is completed, potassium hexafluorophosphate is added and stirring is continued to obtain the metal iridium complex CHO-Ir-H; finally, CHO-Ir-H and sodium hydroxide are mixed and stirred in water to obtain the metal iridium complex. The metal iridium complex of the present invention realizes dual-mode treatment by combining photodynamic therapy and ferroptosis.

The application relates to a photosensitizer for type I photodynamic therapy and a preparation method thereof, and belongs to the photosensitizer field. The photosensitizer is obtained through five-step reactions of phenothiazine, n-bromobutane, phosphorus oxychloride, N-bromosuccinimide, 5-aldehyde-2-thiophene boronic acid, 1,4-dimethylpyridine-1-iodonium and potassium hexafluorophosphate, and can effectively generate type I active oxygen in a small molecule state. The photosensitizer has great prospects in the field of type I photodynamic therapy.

The invention discloses a potassium ion battery based on a high-capacity and high-stability molybdenum sulfide composite electrode and a salt-regulated electrolyte. According to the method, electrostatic spinning is combined with a stepped heat treatment process, ammonium thiomolybdate, polyacrylonitrile and the like are used as precursors, a surfactant is introduced into the precursors to reduce the surface tension of a spinning solution, and then the molybdenum disulfide / carbon composite electrode material with the self-supporting structure is prepared. Meanwhile, the ethylene glycol dimethyl ether electrolyte which takes potassium hexafluorophosphate as a main salt and is added with potassium trifluoromethanesulfonate and potassium bis (fluorosulfonyl) imide in a specific proportion is adopted. The composite material has a synergistic effect with a specific electrolyte, so that the specific capacity and the cycling stability of the potassium ion battery are effectively improved.

The application provides a chromone-modified o-phenanthroline polypyridine Ru(II) series compound and a preparation method and application thereof, the preparation method synthesizes an intermediate A by taking 1,10-o-phenanthroline-5,6-diketone and 6-substituted-4-oxo-4H-benzopyran-3-formaldehyde as raw materials, then the intermediate A is heated to reflux in ethylene glycol solvent and cis-[Ru(2,2'-dipyridine)2Cl2]·2H2O at 120 DEG C for 6h, after the system is cooled to room temperature, an excess amount of a saturated aqueous solution of potassium hexafluorophosphate is added, after a precipitate is separated out, the filter cake is washed with clean water, and the final product is obtained after drying. The synthesis method is simple and easy to operate without steps such as column chromatography.

The invention belongs to the technical field of pharmaceutical analysis, and particularly relates to a method for separating related impurities in a dopurazide tablet and determining the content of each component. According to the method, octadecyl silane bonded silica gel is adopted as a filling agent, a potassium hexafluorophosphate solution is adopted as a mobile phase A, methyl alcohol is adopted as a mobile phase B, and benserazide hydrochloride, a benserazide hydrochloride impurity C and a benserazide hydrochloride impurity E are sequentially separated through gradient elution; and then the sample enters a detector with the detection wavelength of 210 nm to be detected. And calculating the content of each component by adopting an external standard method according to the measured chromatogram. The self-established high performance liquid chromatography is not interfered by other impurities or auxiliary materials, and separation and determination of the benserazide hydrochloride, the benserazide hydrochloride impurity C and the benserazide hydrochloride impurity E can be realized within 35 minutes. The method is high in specificity, high in accuracy and good in precision and durability.

The invention belongs to the technical field of refrigeration material preparation, and relates to a non-electric refrigeration composite coating with a press-blocking effect and a preparation method thereof.The coating technology is adopted, firstly, silicon dioxide aerogel adsorbs a refrigerant potassium hexafluorophosphate to prepare a refrigeration core, then the refrigeration core is coated with polytetrafluoroethylene to obtain modified microspheres, and then the modified microspheres are coated with the silicon dioxide aerogel to obtain the non-electric refrigeration composite coating with the press-blocking effect. The carbon nano tube is further adopted as a heat transfer medium to prepare a refrigeration layer precursor and a heat conduction layer precursor, the electroless refrigeration composite coating is obtained after layer-by-layer coating, and the electroless refrigeration composite coating has a pressing and clamping effect in the environment of-268 DEG C to 300 DEG C, can achieve a good refrigeration effect, has excellent neutral salt mist resistance and low-temperature impact resistance, and can be applied to the field of refrigeration. And the application scene is very wide.

The invention discloses a method for measuring residual quantity of residual impurities DMAP and EDU in synthesis of antitumor drugs, and belongs to the technical field of drug analysis. According to the method, high performance liquid chromatography is adopted for detection; dimethyl sulfoxide is used as a solvent to dissolve the sample for detection; detection conditions of the high performance liquid chromatography are as follows: a chromatographic column is an octadecyl bonded silica gel column; the mobile phase A is a sodium perchlorate buffer solution or a potassium hexafluorophosphate buffer solution; the mobile phase B is acetonitrile; the detector is an ultraviolet detector; the detection wavelength for detecting the DMAP is 278 to 282 nm, and the detection wavelength for detecting the EDU is 198 to 202 nm; a gradient elution mode is adopted. The method is used for detecting DMAP and EDU residues in the raw material medicine, is high in sensitivity and accuracy, does not need a special column, can meet the control limit of the ICH guidance principle on genotoxic impurities and general impurities of the raw material medicine, provides reliable guarantee for impurity control of the raw material medicine, and further guarantees the safety of clinical medication.

The invention relates to the technical field of functional coatings, and provides an electrosilvering imitation coating and a preparation method thereof. In the components of the coating, the mass ratio of the film-forming substance to the organic solvent to the aluminum paste to the auxiliary agent is (20-30): (50-60): (12-18): (1-10). The film-forming substance is polyvinyl butylimidazole hexafluorophosphate grafted modified cellulose acetate butyrate, and the preparation method comprises the following steps: firstly preparing polyvinyl butylimidazole grafted modified cellulose acetate butyrate, then compounding with bromobutane, and then carrying out anion replacement with potassium hexafluorophosphate. By adopting the film-forming substances, the glossiness, distinctness of image and solvent resistance of the coating are improved.

The invention provides a method for detecting the composition proportion of sitamido chloride alkyl, which is carried out by adopting high performance liquid chromatography, a strong acid type cation exchange chromatographic column is adopted as a chromatographic column, and isocratic elution is carried out by using a mixed solution of a mobile phase A and a mobile phase B according to the volume ratio of 45: 55; wherein the mobile phase A is a mixed solution of 8-45mM of sodium perchlorate and 10mM of potassium hexafluorophosphate (the pH value is adjusted to 3.0-4.0); and the mobile phase B is a mixed solution of acetonitrile and isopropanol in a volume ratio of (60-80): (20-40). The method provided by the invention can be used for distinguishing and detecting three alkyl impurities including the dodecyl dimethyl benzyl ammonium chloride, the tetradecyl dimethyl benzyl ammonium chloride and the octadecyl dimethyl benzyl ammonium chloride, and the detection standard of related substances in the sitaammonium chloride pharmaceutic adjuvant is improved. The detection method disclosed by the invention is high in separation degree of each component, strong in specificity, high in sensitivity and good in repeatability and accuracy.

The application belongs to the technical field of organic synthesis, and specifically provides a 2-(4,6-dimethoxy-1,3,5-triazin-2-yl)-1,1,3,3-tetramethylurea hexafluorophosphate, a preparation method and a condensation reagent. The preparation method of the 2-(4,6-dimethoxy-1,3,5-triazin-2-yl)-1,1,3,3-tetramethylurea hexafluorophosphate comprises: making 2-chloro-4,6-dimethoxy-1,3,5-triazine and tetramethylurea undergo a nucleophilic substitution reaction to generate an intermediate; and making the intermediate and potassium hexafluorophosphate undergo an ion exchange reaction to generate the 2-(4,6-dimethoxy-1,3,5-triazin-2-yl)-1,1,3,3-tetramethylurea hexafluorophosphate. The 2-(4,6-dimethoxy-1,3,5-triazin-2-yl)-1,1,3,3-tetramethylurea hexafluorophosphate according to the embodiment of the application can be used as a condensation reagent for forming an amide bond, and compared with condensation reagents such as HBTU and HATU which have two high-energy heteroatomic bonds of N-N and N-O, the thermal hazard of the 2-(4,6-dimethoxy-1,3,5-triazin-2-yl)-1,1,3,3-tetramethylurea hexafluorophosphate is smaller, and the 2-(4,6-dimethoxy-1,3,5-triazin-2-yl)-1,1,3,3-tetramethylurea hexafluorophosphate is suitable for industrial production. In addition, the preparation method according to the embodiment of the application has mild reaction, fewer reaction steps and low operation risk coefficient.

The present invention belongs to the technical field of chemical analysis, and specifically relates to a method for separating and determining posaconazole Z3 and its impurities and solvents by HPLC. The present invention adopts octadecylsilane bonded silica gel filler as the stationary phase, a mixed solution made of potassium hexafluorophosphate solution and methanol in a volume ratio of 90:10 as mobile phase A, and a mixed solution made of acetonitrile and methanol in a volume ratio of 90:10 as mobile phase B, and separates posaconazole Z3 and its related impurities and solvent toluene by gradient elution; after separation, a detector with a detection wavelength of 210nm is used for detection. The related impurities include impurities Z 3e and p-toluenesulfonic acid and / or other related impurities, other related impurities are impurities SM 3d 、Impurity SM3、Impurity SM 3i , impurity Z2, impurity Z 3f And / or methyl p-toluenesulfonate; the method of the invention has strong specificity, high sensitivity, good reproducibility, and the detection result is accurate and reliable.

The invention belongs to the technical field of organic synthesis, and particularly provides 2-(4, 6-dimethoxy-1, 3, 5-triazine-2-yl)-1, 1, 3, 3-tetramethylurea hexafluorophosphate, a preparation method and a condensation reagent. The preparation method of the 2-(4, 6-dimethoxy-1, 3, 5-triazine-2-yl)-1, 1, 3, 3-tetramethylurea hexafluorophosphate comprises the following steps: carrying out nucleophilic substitution reaction on 2-chloro-4, 6-dimethoxy-1, 3, 5-triazine and tetramethylurea to generate an intermediate; and carrying out ion exchange reaction on the intermediate and potassium hexafluorophosphate to generate 2-(4, 6-dimethoxy-1, 3, 5-triazine-2-yl)-1, 1, 3, 3-tetramethylurea hexafluorophosphate. The 2-(4, 6-dimethoxy-1, 3, 5-triazine-2-yl)-1, 1, 3, 3-tetramethylurea hexafluorophosphate provided by the embodiment of the invention can be used as a condensation reagent for forming an amido bond, and compared with condensation reagents with two high-energy heteroatom bonds of N-N and N-O, such as HBTU and HATU, the 2-(4, 6-dimethoxy-1, 3, 5-triazine-2-yl)-1, 1, 3, 3-tetramethylurea hexafluorophosphate is smaller in heat hazard and suitable for industrial production. In addition, according to the preparation method of the embodiment of the invention, the reaction is mild, the reaction steps are few, and the operation danger coefficient is low.

The invention discloses a method for detecting non-amino acid impurities in polymyxin B sulfate for injection, and belongs to the technical field of medical analysis. According to the method, high performance liquid chromatography is adopted, and under the chromatographic conditions, a chromatographic column is an octadecyl silane bonded silica gel chromatographic column; the mobile phase comprises a mobile phase A and a mobile phase B, the mobile phase A is a potassium hexafluorophosphate buffer solution, the mobile phase B is acetonitrile, and the volume ratio of the mobile phase A to the mobile phase B is (50-60): (50-40). Potassium hexafluorophosphate is adopted as a mobile phase A, so that the peak trailing of impurities can be effectively improved, and the sensitivity of the method is improved; according to the method, a mobile phase with a high organic phase proportion is adopted, polymyxin sulfate B1, B2, B3 and B-1 and related amino acid impurities have peaks in dead volume, and detection of non-amino acid impurities is not interfered; the mobile phase system adopted by the invention has no ultraviolet absorption at 200 nm or above, so that the noise of the mobile phase is reduced, and the sensitivity and accuracy of the method are improved.

The invention relates to a high-voltage-resistant electrolyte, a preparation method and application of the high-voltage-resistant electrolyte and a potassium ion battery. The electrolyte comprises electrolyte sylvite and an electrolyte solvent, the electrolyte potassium salt is one or more of potassium hexafluorophosphate, potassium tetrafluoroborate, potassium bis (fluorosulfonyl) imide, potassium trifluoromethanesulfonate, potassium bis (trifluoromethane) sulfonyl imide, potassium nitrate and potassium perchlorate. The electrolyte provided by the invention is simple in manufacturing process and excellent in oxidation stability, and when the electrolyte is applied to the high-voltage potassium ion battery, a stable electrode-electrolyte interface can be formed by preferentially decomposing more anions under the condition that cyclic carbonate is not added as a film-forming cosolvent, so that the stability of the high-voltage potassium ion battery is improved. Therefore, the compatibility of the carbonic ester-based electrolyte with the positive and negative electrodes of the potassium ion battery is improved.

An electrolyte, comprising: an amount of potassium hexafluorophosphate; at least one cyclic carbonate, the at least one cyclic carbonate optionally comprising at least one of ethylene carbonate and propylene carbonate; and at least one organic phosphate, the at least one organic phosphate optionally comprising at least one of trimethyl phosphate and triethyl phosphate. An electrical cell, comprising: the electrolyte according to the present disclosure, and an electrode, the electrode contacting the electrolyte. A method, comprising: any one or more of separating, disposing, or at least partially neutralizing any one or more of HF, HPO2F2, H2PO3F, an organofluorophosphate, a monofluorophosphate, an organophosphate, and a phosphonate evolved from operating an electrical cell that includes as an electrolyte any one or more of LiPF6, NaPF6, and KPF6.