Phosphorescent iridium complex, and preparation method and application thereof
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A technique of phosphorescent iridium complexes and complexes, applied in chemical instruments and methods, compounds containing elements of group 8/9/10/18 of the periodic table, biological testing, etc. Expensive and other issues, to achieve high selectivity, high sensitivity detection, strong staining effect
Active Publication Date: 2012-07-18
INST OF CHEM CHINESE ACAD OF SCI
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In 1998, Pittner et al. developed a flow injection method based on enzyme-linked immunosorbent indirect detection of glutamine content in cell culture medium; in 1998, Hernandez et al. reported a method based on capillary area electrophoresis-laser-induced fluorescence to detect patients with influenza A Glutamine content in cerebrospinal fluid, but these methods have disadvantages such as cumbersome operation, expensive equipment, and high detection limit.
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[0023] The experimental methods used in the following examples are conventional methods unless otherwise specified.
[0024] The materials and reagents used in the following examples can be obtained from commercial sources unless otherwise specified.
[0025] Preparation and application of phosphorescent iridium complex shown in formula (I)
[0026] 1. Complex shown in formula (II) [(pba) 2 Ir(μ-Cl 2 )Ir(pba) 2 ] preparation
[0027] Reference literature (W. Tan, Q. Zhang, J. J. Zhang, H. Tian. Org. Lett. 2009, 11, 161-164).
[0028] Weigh 1mmol of IrCl 3 ·H 2 O and 2.5mmol 4-(2-pyridyl)benzaldehyde were dissolved in a mixed solution of ethylene glycol ether and water (volume ratio 3:1), heated, stirred and refluxed for 24h to obtain a yellow precipitate; filtered and dried to obtain [ (pba) 2 Ir(μ-Cl 2 )Ir(pba) 2 ].
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Abstract
The invention discloses a phosphorescent iridium complex, and a preparation method and application thereof. A chemical formula of the phosphorescent iridium complex is [Ir(pba)2(DMSO)2]PF6 and a structural formula of the phosphorescent iridium complex is shown as a formula (I), wherein pba is expressed as 4-(2-pyridyl)benzaldehyde, DMSO is expressed as dimethylsulfoxide. A method for preparing the phosphorescent iridium complex comprises the following steps of: reacting a complex shown as a formula (II) with the dimethylsulfoxide; and adding potassium hexafluorophosphate into a reaction system and stirring to obtain the phosphorescent iridium complex. The invention also provides application of the phosphorescent iridium complex to the detection of glutamine. By the phosphorescent iridium complex, the high-selectivity and high-sensitivity detection of the glutamine can be realized, and a possibility for constructing a fluorescent chemical sensor for detecting the glutamine in high selectivity and high sensitivity is provided; and the phosphorescent iridium complex has a high dyeing effect on the glutamine in cells, and is expected to be used for detecting the Gln in the physiological and pathological processes.
Description
technical field [0001] The invention relates to a phosphorescent iridium complex, a preparation method and application thereof. Background technique [0002] Glutamine (Glutamine, referred to as Gln) is one of the most abundant amino acids in mammals. The concentration in normal human plasma is 0.6-0.9 mmol / L, accounting for 20% of the total free amino acids in plasma and 20% of the total free amino acids in the body. 60%. In 1935, Kerbs first discovered the ability of mammalian kidneys to synthesize and decompose Gln, emphasizing that "most amino acids have multiple functions, but the function of Gln is the most abundant." Eagle (H.Eagle.J.Biol.Chem.1955, 214, 839-852), Windmueller (H.G. Windmueller. Advanced in Enzymology and Related Areas of Molecular Biology.1982, 53, 210-237), Kapadia (C.R. Kapadia, M.F. Colpoys, Z.M. Jiang, D.J. Johnson, R.J. SmithWilm, D.W. .J.Parenter.Enter.Nutr.1985,9,583-589), Alverdy(J.C.Alverdy.J.Parenter.Enter.Nutr.1990,14,S109-S113), Souba(W....
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