Industrial production method for Daclatasvir key intermediate

A technology of daclatasvir and production method, applied in the field of biochemical industry, can solve the problems of many steps, long synthesis route, low yield and the like
CN109503557AInactive Publication Date: 2019-03-22GENCHEM & GENPHARM CHANGZHOU CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
GENCHEM & GENPHARM CHANGZHOU CO LTD
Publication Date
2019-03-22
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to the technical field of biochemical engineering and specifically relates to an industrial production method for a Daclatasvir key intermediate 5,5'-[1,1'-biphenyl]-4,4'-diyl di[2-(2S)-2-pyrrolidyl-1H-imidazole]terthydrochloride. The 5,5'-[1,1'-biphenyl]-4,4'-diyl di[2-(2S)-2-pyrrolidyl-1H-imidazole]terthydrochloride is prepared according to a one-pot method. Compared with aconventional process, the industrial production method for the Daclatasvir key intermediate 5,5'-[1,1'-biphenyl]-4,4'-diyl di[2-(2S)-2-pyrrolidyl-1H-imidazole]terthydrochloride is capable of efficiently and stably producing high-quality 5,5'-[1,1'-biphenyl]-4,4'-diyl di[2-(2S)-2-pyrrolidyl-1H-imidazole]terthydrochloride, the purity of the intermediate is greater than 99%, and the content of unknown single impurities is smaller than 0.3%.
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Description

technical field

[0001] The invention relates to the field of biochemical technology, in particular to the key intermediate of daclatasvir 5,5'-[1,1'-biphenyl]-4,4'-diylbis[2-(2S)-2-pyrrole Alkyl-1H-imidazole]tetrahydrochloride industrial production method. Background technique

[0002] 5,5'-[1,1'-Biphenyl]-4,4'-Diylbis[2-(2S)-2-pyrrolidinyl-1H-imidazole]tetrahydrochloride, daclatasvir intermediate body. English name: 1H-IMidazole,5,5'-[1,1'-biphenyl]-4,4'-diylbis[2-(2S)-2-pyrrolidinyl-,hydrochloride(1:4). CAS number: 1009119-83-8.

[0003] 5,5'-[1,1'-biphenyl]-4,4'-diylbis[2-(2S)-2-pyrrolidinyl-1H-imidazole]tetrahydrochloride is a synthetic daclatasvir key intermediates. Daclatasvir (Daklinza) is an oral hepatitis C virus (HCV) NS5A inhibitor developed by Bristol-Myers Squibb (BMS). After the European Union approved its combination with other antiviral drugs for the treatment of genotype 1-4 chronic hepatitis C adult patients in 2014, the US FDA approved its combinatio...

Claims

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