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Extraction process for aristolochic acid C

An aristolochic acid and extraction process technology, applied in the direction of organic chemistry and the like, can solve the problems of high cost and insufficient extraction, and achieve the effects of low cost, improved extraction rate and simple process

Inactive Publication Date: 2018-12-14
湖州展舒生物科技有限公司
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  • Abstract
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AI Technical Summary

Problems solved by technology

[0003] At present, when extracting aristolochic acid C from the rhizomes of Aristolochia, the extraction is not thorough enough, the cost is high, and it cannot meet the needs of the market

Method used

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Examples

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Embodiment Construction

[0012] The present invention will be described in further detail below through specific examples.

[0013] A process for extracting aristolochic acid C, comprising the following steps:

[0014] 1), Aokimi is sent into a pulverizer for pulverization to obtain pulverized Aokimi;

[0015] 2) Carrying out two ethanol reflux extractions on the pulverized Acacia sinensis, so as to obtain the extract, the concentration of ethanol is 60-85%;

[0016] 3) Concentrate the extract, then add tetrahydrofuran and ethyl acetate into the concentrate at a ratio of 2:8, and cool to -10°C, and after standing for 12-36 hours, crystallize to obtain aristolochic acid c.

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Abstract

The invention discloses an extraction process for aristolochic acid C. The extraction process comprises the following steps: 1) feeding radix aristolochiae into a crusher to be crushed to obtain crushed radix aristolochiae; 2) carrying out ethanol reflux extraction on the crushed radix aristolochiae twice so as to obtain an extraction solution; and 3) concentrating the extraction solution, addingtetrahydrofuran and ethyl acetate in a proportion of 2 to 8 into the concentrated solution, cooling the solution to 10 DEG C below zero, and putting the solution for 12-36 hours to crystallize to obtain the aristolochic acid C. By taking a novel mixed solvent tetrahydrofuran and ethyl acetate as a crystallizing solvent, the extraction rate of the aristolochic acid C is improved greatly, and the extraction process is simple and low in cost.

Description

technical field [0001] The invention relates to a process for extracting aristolochic acid C. Background technique [0002] The molecular formula of aristolochic acid C is C 16 h 9 NO 7 , the molecular weight is 327.2452, it is a reddish-brown solid at normal temperature and pressure, mainly derived from the rhizome of Aristolochia, soluble in ethanol, ethyl acetate, slightly soluble in petroleum ether, insoluble in water, relatively stable at room temperature Well, it needs to be stored in a cool place away from light. [0003] At present, when extracting aristolochic acid C from the rhizomes of Aristolochia, the extraction is not thorough enough, the cost is high, and the market demand cannot be met. Contents of the invention [0004] In view of the above problems, the present invention provides a process for extracting aristolochic acid C, which is simple, thorough and low in cost. [0005] The technical scheme adopted in the present invention is: [0006] A proce...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D317/70
CPCC07D317/70
Inventor 吴建华
Owner 湖州展舒生物科技有限公司
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