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Preparation method of Coreopsis tinctoria extract for improving diabetic nephropathy

A technology for diabetic nephropathy and extracts, which is applied in the field of preparation of snow chrysanthemum extracts, can solve the problems that the safety of extracts needs to be improved, and achieve the effects of increasing saponin content, improving hyperlipidemia, and improving nephropathy

Inactive Publication Date: 2018-12-18
上海赛肽生命科学研究有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the safety and quality of the extracts of the existing extraction methods need to be improved, so a new extraction method is needed to extract the snow chrysanthemum

Method used

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  • Preparation method of Coreopsis tinctoria extract for improving diabetic nephropathy

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Effect test

Embodiment 1

[0024] A preparation method of snow chrysanthemum extract for improving diabetic nephropathy, comprising the following steps:

[0025] S1. Soaking: Weigh the snow chrysanthemum powder, mix it according to the mass ratio of snow chrysanthemum powder and water at 1:2, first soak and extract for 12 hours at a medium temperature of 50°C, and then conduct a second time at a low temperature of 5°C Soak and extract for 24 hours, and then conduct the third soak and extract for 12 hours at 70°C to obtain the snow chrysanthemum aqueous solution;

[0026] S2. Extraction: extract the snow chrysanthemum aqueous solution with a strong electric field for 65 minutes, the extraction electric field strength is 2.0kV, the pulse frequency is 2000Hz, and the electrode distance is 5mm, to obtain the snow chrysanthemum extract;

[0027] S3. Suction filtration: Suction filtration of the snow chrysanthemum extract, the suction filtration temperature is controlled at 50-60° C., and the suction filtrati...

Embodiment 2

[0030] A preparation method of snow chrysanthemum extract for improving diabetic nephropathy, comprising the following steps:

[0031] S1. Soaking: Weigh snow chrysanthemum powder, mix it according to the mass ratio of snow chrysanthemum powder and water at 1:5, first soak and extract for 6 hours at medium temperature at 60°C, and then carry out the second time at low temperature at 10°C Soak and extract for 18 hours, and then conduct the third soak and extract for 8 hours at 90°C to obtain the snow chrysanthemum aqueous solution;

[0032] S2. Extraction: extract the snow chrysanthemum aqueous solution with a strong electric field for 55 minutes, the extraction electric field strength is 2.2kV, the pulse frequency is 2400Hz, and the electrode distance is 3mm, to obtain the snow chrysanthemum extract;

[0033] S3. Suction filtration: Suction filtration of the snow chrysanthemum extract, the suction filtration temperature is controlled at 50-60° C., and the suction filtration ti...

Embodiment 3

[0036] A preparation method of snow chrysanthemum extract for improving diabetic nephropathy, comprising the following steps:

[0037] S1. Soaking: Weigh snow chrysanthemum powder, mix it according to the mass ratio of snow chrysanthemum powder and water at 1:3, first soak and extract at 55°C for 8 hours, and then at 8°C for the second time Soak and extract for 20 hours, and then conduct the third soak and extract for 10 hours at 80°C to obtain the snow chrysanthemum aqueous solution;

[0038] S2. Extraction: extract the snow chrysanthemum aqueous solution with a strong electric field for 60 minutes, the extraction electric field strength is 2.1kV, the pulse frequency is 2200Hz, and the electrode distance is 4mm, to obtain the snow chrysanthemum extract;

[0039] S3. Suction filtration: Suction filtration of the snow chrysanthemum extract, the suction filtration temperature is controlled at 50-60° C., and the suction filtration time is controlled at 5-10 minutes;

[0040] S4....

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Abstract

The invention provides a preparation method of Coreopsis tinctoria extract for improving diabetic nephropathy. The method comprises the following steps: weighing Coreopsis tinctoria powder, uniformlymixing the Coreopsis tinctoria powder with water according to a mass ratio of 1:(2-5), carrying out first-stage immersion extraction under medium-temperature conditions, carrying out second-stage immersion extraction under low-temperature conditions, carrying out third-stage immersion extraction under high-temperature conditions to obtain an aqueous solution of Coreopsis tinctoria; extracting theaqueous solution of Coreopsis tinctoria with a strong electric field for 55-65 min to obtain a Coreopsis tinctoria extract liquid; performing suction filtration on the Coreopsis tinctoria extract liquid; and carrying out rotary evaporation on a filtrate obtained after the suction filtration to obtain extract that is the Coreopsis tinctoria extract. The Coreopsis tinctoria extract prepared in the invention is safe and reliable, has high content of flavones, chlorogenic acid and saponins, and can be well applied to improve the diabetic nephropathy.

Description

technical field [0001] The invention relates to the technical field of snow chrysanthemum, in particular to a preparation method of an extract of snow chrysanthemum for improving diabetic nephropathy. Background technique [0002] Chronic kidney disease (CKD) affects 8-16% of the world's population and is now considered one of the rising non-communicable diseases worldwide. CKD growth rate is expected to increase exponentially in developed countries such as the United States, given the growing aging population. Beyond primary preventive measures, the most common causes of CKD include diabetes and hypertension, and there are currently no effective interventions to halt progression to end-stage renal failure. Renal replacement therapy can prevent or delay progression to end-stage renal disease (ESRD) morbidity, but increases mortality and treatment costs. [0003] Diabetic nephropathy (diabetic nephropathy, DN) is a serious and most harmful chronic complication caused by dia...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/287A61P3/10A61P3/06A61P13/12A61P1/16A61K133/00
CPCA61K36/287A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61P1/16A61P3/06A61P3/10A61P13/12
Inventor 鲁南马立新柯松轩刘英
Owner 上海赛肽生命科学研究有限公司
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