A kind of preparation method of drug-loaded hemostatic sponge and prepared drug-loaded hemostatic sponge

Abstract

The invention discloses a preparation method of drug-loading hemostatic sponge. The preparation method comprises the following steps: (1) preparing lignocelluloses sponge; and (2) loading the lignocelluloses sponge with chitosan and a hemostatic drug in a spraying or immersion manner, and freeze drying to obtain the drug-loading hemostatic sponge. A preparation method of the lignocelluloses spongecomprises the following steps: (1) freezing an alkali urea solution, forming icy slurry, adding lignocelluloses into the icy slurry, and obtaining a lignocelluloses solution; (2) adding a surfactantinto the lignocelluloses solution, stirring, and forming a foam body; (3) freezing the foam body into foam icy slurry, adding a pore forming agent into the foam icy slurry, injection molding, freezing, aging, and obtaining gel; and (4) soaking to remove the surfactant and the pore forming agent in the gel, freeze shaping, freeze drying, and obtaining the lignocelluloses sponge. By adopting the drug-loading hemostatic sponge prepared by the invention, by virtue of the synergistic effect of the chitosan and hemostatic drug, the blood on the surface of a wound can be rapidly absorbed, the blood coagulation of the wound can be effectively promoted, and the bleeding can be rapidly stopped.

Description

technical field [0001] The invention belongs to the field of medical polymer materials, and in particular relates to a preparation method of a drug-loaded hemostatic sponge, and also relates to a drug-loaded hemostatic sponge product prepared by the method. Background technique [0002] Blood is an important carrier that transports oxygen to the body. When the human body loses too much blood due to injury, the organs and cells will malfunction and fail, which will affect life safety. Uncontrolled bleeding has always been the leading cause of casualties. Although protected by personal protective equipment such as bulletproof vests and helmets, in modern warfare, bleeding is still the main cause of death in battlefield trauma, especially when the trauma occurs in the joints of limbs such as armpits, groin, neck, etc., these parts cannot be used with tourniquets Or manual compression for hemostasis can easily lead to hemorrhagic shock or even death. Therefore, timely and eff...

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Problems solved by technology

[0003] The rapid hemostatic materials reported at present mainly include hemostatic powder (zeolite, collagen powder and potato starch), porous sponge (gelatin sponge, collagen sponge), fibrin glue, etc., but they all have certain deficiencies: gelatin and collagen Tissue adhesion is poor, and the hemostatic function of both depends on sufficient platelets and coagulation factors; fibrin is derived from blood and may cause viral infection; porous zeolite and potato starch will release after absorbing water in the blood A lot of heat, which can easily lead to wound inflammation

[0004] The Chinese invention patent application with the publication number CN 107050502 A introduces a superabsorbent polymer hydrogel xerogel sponge and its preparation method and application. It uses chitosan as the skeleton and superabsorbent polymer as the branched chain , to prepare a three-dimensional network porous sponge with a flexible structure of macromolecules or polymers as a cross-linking agent. Superabsorbent polymers such as polyacrylamide and cross-linking agent glutaraldehyde will bring certain toxicity to the porous sponge, which is a potential danger; moreover, the material is not high in strength and is easy to break into tiny debris, which may cause motion Venous thrombosis

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