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Novel chalcone compound with anti-aging function and application of compound

A compound, anti-aging technology, applied in the direction of organic chemistry, organic chemical methods, medical preparations containing active ingredients, etc., can solve problems such as increased cell death rate, shortened life expectancy of organisms, oxidative stress, etc.

Inactive Publication Date: 2019-01-04
HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If the function of the antioxidant defense system is weakened and the oxidative damage of free radicals is excessive, it will eventually lead to oxidative stress, the death rate of cells will be greatly increased, and the life expectancy of organisms will be shortened accordingly

Method used

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  • Novel chalcone compound with anti-aging function and application of compound
  • Novel chalcone compound with anti-aging function and application of compound
  • Novel chalcone compound with anti-aging function and application of compound

Examples

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Effect test

Embodiment Construction

[0023] Compounds with the following chemical structures and pharmaceutically acceptable salts thereof:

[0024]

[0025] Compound (B36) is:

[0026] (E)-1-[3-(Dimethylamino)phenyl]-3-[4-hydroxy-3-(3-methylbut-3-en-2-yl)phenyl]-prop-2-en-1-one

[0027] (E)-1-[3-(diethylamino)phenyl]-3-[4-hydroxy-3-(3-methyl-3-buten-2yl)phenyl]-2-propenyl - the compound described in 1-ketone, which is used for related diseases such as aging and oxidative damage.

[0028] A pharmaceutical composition for antiaging or diseases related to oxidative damage, which comprises the compound and a pharmaceutically acceptable carrier. The pharmaceutical composition is made into tablets, capsules, oral liquids, injections, powders, ointments or external medicinal liquids.

[0029] The application of the compound in the preparation of medicines for anti-aging or diseases related to oxidative damage.

[0030] 1 The results of B36 on the lifespan-related behavioral indicators of Drosophila

[0031] 1.1...

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Abstract

The invention provides a novel chalcone compound with an anti-aging function. The novel chalcone compound can be used for preparing crude drugs in various dosage forms and with aging or oxidative damage related medicines, and used for medical application for treating aging or oxidative damage related diseases.

Description

technical field [0001] The invention belongs to the field of medicinal chemistry, in particular, the invention relates to the chemical structure of novel chalcone compounds with anti-aging effect. In addition, the present invention also relates to the anti-aging effect, anti-fatigue and immune enhancement effects and uses of the compound. Background technique [0002] The mystery of aging is an enduring hot topic. For a long time, people have conducted in-depth research on the causes of human aging, but so far, the real mechanism of aging is still an unsolved mystery. In order to explore the mystery of aging, many theories have emerged, trying to explain the causes of aging from different angles, such as free radical damage theory, immune decline theory, telomere theory, molecular cross-linking theory, neuroendocrine theory, mitochondrial DNA damage theory and recent years. The interaction between autophagy and aging, etc., learning from each other among theories has gradua...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C225/22A61K31/136A61P39/06
CPCA61P39/06C07B2200/09C07C225/22
Inventor 冯宇飞王艳艳牛雯颖吕晨
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE
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