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Extraction method suitable for water-soluble heat-sensitive ingredients of traditional Chinese medicines

An extraction method and water-soluble technology, which is applied in the field of extraction of water-soluble heat-sensitive components of traditional Chinese medicine, can solve the problems of damage to heat-sensitive components and affecting the efficacy of formula granules, so as to reduce the amount of medicine taken, reduce the risk of unqualified, and extract the amount of medicinal materials. big effect

Inactive Publication Date: 2019-02-15
SHINEWAY PHARMA GRP LTD
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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the problem that the existing extraction process of traditional Chinese medicine greatly damages heat-sensitive components in medicinal materials and seriously affects the efficacy of formula granules, the present invention provides an extraction method suitable for water-soluble heat-sensitive components of traditional Chinese medicine

Method used

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  • Extraction method suitable for water-soluble heat-sensitive ingredients of traditional Chinese medicines
  • Extraction method suitable for water-soluble heat-sensitive ingredients of traditional Chinese medicines
  • Extraction method suitable for water-soluble heat-sensitive ingredients of traditional Chinese medicines

Examples

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Embodiment 1

[0039] A kind of extraction method of safflower medicinal material:

[0040] Weigh the safflower medicinal material, remove visible foreign matter and impurities, put the safflower decoction pieces into a static multifunctional extraction tank, add 6 times the weight of the safflower medicinal material in boiling water at 95-100°C, soak for 20 minutes, and filter; 8 times the weight of safflower medicinal material in boiling water at 95-100°C, soak for 20 minutes, and filter; add 10 times the weight of safflower medicinal material in boiling water at 95-100°C, soak for 30 minutes, and filter; combine the three extracts, Import the extract into a vacuum single-effect concentration tank, turn on the steam valve and vacuum pump, and carry out vacuum drying at a pressure of -0.08MPa, a concentration temperature of 60°C, and a relative density of 1.04 (60°C). In the hot tank, the temperature was raised to 75°C for spray drying. The air inlet temperature was 167°C and the outlet air...

Embodiment 2

[0042] A kind of extraction method of forsythia medicinal material:

[0043] The forsythia medicinal material is weighed, and the shell of the forsythia medicinal material is crushed with a crushing machine, the shell breaking rate is not less than 95%, and the particle size of the forsythia is 0.1-1 cm. Put the crushed forsythia decoction pieces into a static multifunctional extraction tank, add 4 times the weight of forsythia in boiling water at 95-100°C, soak for 20 minutes, and filter; add 6 times the weight of forsythia at 95-100°C to the dregs Soak in boiling water for 30 minutes, filter; add 8 times the weight of forsythia in boiling water at 95-100°C to the dregs, soak for 30 minutes, and filter; combine the three extracts, import the extract into a vacuum single-effect concentration tank, open Steam valve and vacuum pump for vacuum drying, the pressure is -0.07MPa, the concentration temperature is 65°C, the relative density of the concentrate is 1.02 (60°C), the conce...

Embodiment 3

[0045] A kind of extraction method of honeysuckle medicinal material:

[0046]Weigh the honeysuckle medicinal material, and use a pulverizer to crush the honeysuckle medicinal material into coarse particles with a particle size below 1cm. Put the crushed honeysuckle decoction pieces into a static multifunctional extraction tank, add 95-100°C boiling water of 5 times the weight of the honeysuckle medicinal material, soak for 30 minutes, and filter; add 95-7 times the weight of the honeysuckle medicinal material to the medicinal residue. Soak in boiling water at 100°C for 30 minutes, filter; add 9 times the weight of honeysuckle in boiling water at 95-100°C to the dregs, soak for 20 minutes, filter; combine the three extracts, and import the extract into a vacuum single-effect concentration tank , turn on the steam valve and vacuum pump, carry out vacuum drying, the pressure is -0.09MPa, the concentration temperature is 70°C, the relative density of the concentrate is 1.10 (60°C...

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Abstract

The invention provides an extraction method suitable for water-soluble heat-sensitive ingredients of traditional Chinese medicines. The extraction method suitable for water-soluble heat-sensitive ingredients of traditional Chinese medicines comprises the following step: adding water at the temperature of 95-100 DEG C in medicinal materials to soak and extract the medicinal materials, wherein soaking time lasts for 10-30 min, the extraction times are 3-5 times, and the environment temperature is 20-30 DEG C. In the provided extraction method, boiling water at the temperature of 95-100 DEG C isadopted to repeatedly soak and extract the traditional Chinese medicinal materials, by strictly control over the soaking time and the extraction times, it ensures that effective constituents are leached fully, and loss of the heat-sensitive ingredients is reduced. The used boiling water can further kill microorganisms in water and an extracting solution, the storage time of the extracting solutionis prolonged, the risks of unqualified bacterial inspection of finished products are reduced, meanwhile, soluble substances of water-soluble impurities in the medicinal materials are further reduced,the content of the effective constituents is increased, and the dosage of a patient is reduced.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical and chemical production, in particular to an extraction method suitable for water-soluble heat-sensitive components of traditional Chinese medicine. Background technique [0002] With the continuous advancement of science and technology, traditional Chinese medicine dosage forms are not limited to traditional soups, pills, powders, ointments, etc. New dosage forms such as traditional Chinese medicine formula granules have been accepted and used by a large number of patients. Traditional Chinese medicine formula granules, also known as decoction-free Chinese herbal pieces, new decoction pieces, refined decoction pieces, etc., refer to extracting the active ingredients in traditional Chinese medicine decoction pieces through the extraction method of traditional Chinese medicine preparations, selecting appropriate solvents and techniques, and then through concentration, drying, Made into granu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/286A61K36/634A61K36/355A61K36/48A61K36/537
CPCA61K36/286A61K36/355A61K36/48A61K36/537A61K36/634A61K2236/331A61K2236/39A61K2236/51
Inventor 高晗孙福仁张肖建田方耿艳梅李军山李振江
Owner SHINEWAY PHARMA GRP LTD
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