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Biochip hybridization device

A biochip and chip technology, applied in biochemical cleaning devices, enzymology/microbiology devices, biomass post-processing, etc., can solve problems such as chip cross-contamination, and achieve a perfect sealing effect

Pending Publication Date: 2019-02-15
泰普生物科学(中国)有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] The technical problem to be solved by the present invention is to provide a biological chip hybridization device, which can solve the problem of cross-contamination caused by multiple partitions of the chip in the prior art, and can obtain a good hybridization sealing effect

Method used

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Embodiment 1

[0033] Please refer to Figure 1-8 , Embodiment 1 of the present invention is:

[0034] The biochip hybridization device of this embodiment comprises, from bottom to top, a magnetic material layer 1, a chip substrate layer 2 to be hybridized, a silica gel layer 3, and a substrate layer 4 with a magnetic material inside. From the perspective of size and specification, in the above-mentioned hierarchical structure, the length and width of the magnetic material layer 1, the chip substrate layer 2 to be hybridized and the substrate layer 4 are the same, and the length of the silica gel layer 3 is smaller than that of the magnetic material layer 1, the chip substrate to be hybridized. Layer 2 and substrate layer 4, the width of silica gel layer 3 is slightly smaller than the magnetic material layer 1, chip substrate layer 2 to be hybridized and substrate layer 4. The sample-free surface of the chip substrate layer 2 to be hybridized is facing the magnetic material layer 1, and the...

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Abstract

The invention relates to a biochip hybridization device. The biochip hybridization device comprises a magnetic material layer, a to-be-hybridized chip substrate layer, a silica gel layer and a base material layer internally provided with a magnetic material which are sequentially arranged in a layered manner from bottom to top; a fixed groove is formed in one surface of the base material layer; the silica gel layer extends into the fixed groove from one surface of the silica gel layer and is partially embedded in the fixed groove in the thickness direction; at least one partition which is separated from one another and sealed is arranged on the other surface of the silica gel layer; and the at least one partition arranged on the silica gel layer is respectively corresponding to at least one detection sample on the dotted surface of the to-be-hybridized chip substrate layer one by one. The biochip hybridization device provided by the invention can solve the problem of chip cross contamination caused by multiple partitions in the prior art and achieve a good hybrid sealing effect.

Description

technical field [0001] The invention relates to biological detection technology, in particular to a biological chip hybridization device. Background technique [0002] Chips in the prior art generally use conventional glass slides with a size of about 75mm*25mm*1mm. The hybridization liquid is dropped on the probe area of ​​the biochip, and is pressed on the hybridization liquid with a pressure sheet (cover glass) to prevent the hybridization liquid from overflowing. , and then put the hybridization solution and the chip with the pressed sheet into the hybridization box, and press the cover of the hybridization box with adhesive strips to seal and keep moisture. [0003] The crystal core microarray chip hybridization box developed by Beijing Boao Biotechnology is a representative existing technology of the biochip hybridization box (see figure 1 shown, or see the website http: / / science.capitalbio.com / hcysj / swxphc / 10708.shtml). [0004] When it is necessary to detect more t...

Claims

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Application Information

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IPC IPC(8): C12M1/34C12M1/00
CPCC12Q1/6813
Inventor 翁长仁张洪彬
Owner 泰普生物科学(中国)有限公司
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