Biodegradable hemostatic bone wax and preparation method thereof

A biodegradable, bone wax technology, applied in pharmaceutical formulations, drug delivery, applications, etc., can solve the problems of non-degradable absorption of bone wax, unfavorable wound healing, etc., and achieve degradable and rapid hemostasis performance, good blocking effect, composition simple effect

Inactive Publication Date: 2019-03-19
GUANGZHOU SUN SHING BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a biodegradable hemostatic bone wax aiming at the non-degradable absorption of bone wax in the prior art, which is not conducive to wound healing and other defects left in the body

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A biodegradable hemostatic bone wax is prepared from acetic acid, glycerin and keratin, and the mass ratio of the acetic acid, glycerin and keratin is 1:1:8.

[0024] The hemostatic bone wax comprises the following steps: S1. adding keratin to the acetic acid solution, and stirring continuously for 30 minutes in a constant temperature water bath at 30° C.; S2. adding glycerin, and stirring for another 10 minutes to mix well.

Embodiment 2

[0026] A biodegradable hemostatic bone wax is prepared from acetic acid, glycerin and keratin, and the mass ratio of the acetic acid, glycerin and keratin is 1:2:9.

[0027] The hemostatic bone wax comprises the following steps: S1. adding keratin into the acetic acid solution, and stirring continuously for 30 minutes in a constant temperature water bath at 40° C.; S2. adding glycerin, and stirring for another 15 minutes to mix well.

Embodiment 3

[0029] A biodegradable hemostatic bone wax is prepared from acetic acid, glycerin and keratin, and the mass ratio of the acetic acid, glycerin and keratin is 1:3:10.

[0030] The hemostatic bone wax comprises the following steps: S1. Adding keratin into the acetic acid solution, stirring continuously for 40 minutes in a constant temperature water bath at 30° C.; S2. Adding glycerin, stirring for another 12 minutes to mix well.

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Abstract

The invention provides biodegradable hemostatic bone wax. The preparative components are composed of acetic acid, glycerin and keratin, wherein a mass ratio of the acetic acid to glycerin to keratin is 1: (1-3): (8-10). The preparation method comprises the following steps: adding keratin into an acetic acid solution, and continuously stirring in a thermostatic water bath; and adding glycerin, anduniformly stirring and mixing. The hemostatic bone wax disclosed by the invention has degradability, excellent plugging performance and rapid hemostatic performance.

Description

technical field [0001] The invention relates to the technical field of hemostatic materials, in particular to a biodegradable hemostatic bone wax and a preparation method thereof. Background technique [0002] Bone wax is a material that physically blocks the bleeding of capillaries in the bone marrow. It can effectively block the bleeding of spongy bone, and can be used to stop bleeding when the bone oozes in various emergency patients. The specific mechanism of bone wax is as follows: on the one hand, bone wax has a very high absorption effect on liquid during the hemostasis process, and promotes the concentration of platelets by rapidly absorbing the water in the blood on the bleeding wound, thereby enhancing the aggregation speed and aggregation ability of platelets ; On the other hand, the bone wax forms a hydrogel after absorbing water, which can be blocked on the surface of the wound, increasing the effect of hemostasis. In addition, after the bone wax absorbs water ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/00A61L24/10
CPCA61L24/00A61L24/001A61L24/0042A61L24/108A61L2400/04C08L89/00
Inventor 曾晨光王栋许羽冬刘云奇唐婷李少军杨习锋
Owner GUANGZHOU SUN SHING BIOTECH CO LTD
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