Compound preparation containing potassium competitive acid blocker and non-steroidal anti-inflammatory drug

A technology of non-steroidal anti-inflammatory drugs and compound preparations, applied in the field of medicine

Inactive Publication Date: 2019-03-22
JIANGSU JIBEIER PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The problem to be solved by the present invention is: 1. To make the non-steroidal anti-inflammatory drug form a stable weakly alkaline microenvironment in the stomach, it is necessary to ensure that the non-steroidal anti-inflammatory drug and the potassium ion competitive acid blocker are proportioned Use; ②NSAIDs and potassium ion competitive acid blockers do not directly contact; ③The preparation technology must be simple and easy to implement, and cannot cause burdens on enterprises, and then spread the cost to patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Aceclofenac

[0016] Preparation method: mix the prescribed amount of aceclofenac, tartaric acid and 90g lactose, wet granulate with 10% starch slurry, boil and dry; mix the aceclofenac granules with 10g microcrystalline cellulose and 8g talcum powder, Press into tablets, wrap with isolation layer; mix deuterated vonoprazan, 5g of sodium carboxymethylcellulose and 5g of lactose, add water to moisten, wrap around the core of the tablet, and dry to obtain.

Embodiment 2

[0018] Aceclofenac

[0019] Preparation method: mix the prescribed amount of aceclofenac, tartaric acid and 95g lactose, wet granulate with 10% starch slurry, boil and dry; mix the aceclofenac granules with 12g microcrystalline cellulose and 9g talcum powder, Press into tablets, wrap with isolation layer; mix deuterated vonoprazan, 6g of carboxymethylcellulose sodium and 5g of lactose, add water to moisten, wrap around the tablet core, and dry to obtain.

Embodiment 3

[0021] Aceclofenac

[0022] Preparation method: mix the prescribed amount of aceclofenac, tartaric acid and 150g lactose, wet granulate with 10% starch slurry, boil and dry; mix the aceclofenac granules with 20g microcrystalline cellulose and 16g talcum powder, Press into tablets, wrap with isolation layer; mix deuterated vonoprazan, 10g of carboxymethylcellulose sodium and 10g of lactose, add water to moisten, wrap around the tablet core, and dry to obtain.

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PUM

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Abstract

The invention discloses a compound preparation containing a potassium competitive acid blocker and a non-steroidal anti-inflammatory drug. The compound preparation is characterized by being an inner and outer multilayer preparation prepared from the potassium competitive acid blocker and the non-steroidal anti-inflammatory drug, wherein an isolation layer is arranged in the middle of an inner-layer medicine and an outer-layer medicine, and the potassium competitive acid blocker is prevented from making contact with the non-steroidal anti-inflammatory drug. According to the compound preparation, the potassium competitive acid blocker such as deuterated vonoprazan can inhibit gastric acid secretion, the clinical symptoms such as hyperchlorhydria and upper abdominal pain can be ameliorated, the adverse irritation of the non-steroidal anti-inflammatory drug such as aceclofenac to stomach can be reduced, the occurrence rate of gastric mucosa erosion and ulcers can be remarkably decreased, and therefore the effect of protecting the stomach is achieved.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a compound preparation prepared by a specific process from a potassium ion competitive acid blocker, a non-steroidal anti-inflammatory drug and a pharmaceutical auxiliary material. Background technique [0002] Potassium ion competitive acid blocker deuterated vonoprazan is a new type of gastric acid secretion inhibitor, the specific structural formula is as follows: [0003] . [0004] It is classified as a potassium-competitive acid inhibitor because it competitively inhibits the binding of potassium ions to hydrogen-potassium ATPase during the final step of gastric acid secretion from parietal cells. Deuterated vonoprazan has a strong and long-lasting inhibitory effect on gastric acid secretion, and can inhibit the recurrence of gastric ulcer or duodenal ulcer caused by aceclofenac and non-steroidal anti-inflammatory drugs. [0005] Currently, proton pump inhibitors (PPIs) are wid...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K31/4439A61K31/216A61K31/5415A61K9/20A61P1/04A61P29/00
CPCA61K9/2054A61K9/209A61K31/216A61K31/4439A61K31/5415A61K45/06A61K2300/00
Inventor 魏福荣聂丽云吴修艮
Owner JIANGSU JIBEIER PHARMA
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