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The use of the compound

A compound and application technology, applied in the field of preparation of medicines for improving sleep, can solve the problems such as isorosmarinic acid glycoside and its derivatives that have not been reported yet, and achieve the effects of improving sleep onset rate, better effect and improving sleep.

Active Publication Date: 2020-11-06
BEIJING UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, there has been no report on the application of isosmarinic acid and its derivatives in improving sleep

Method used

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  • The use of the compound
  • The use of the compound
  • The use of the compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] 1. Reagents and Experimental Animals

[0069] 1.1 Reagents

[0070] Isorosmarinic acid reference substance (batch number: 178895255) was purchased from Chengdu Aifa Biotechnology Co., Ltd., rosmarinic acid reference substance (batch number: 20283925) was purchased from Shanghai Yuanye Biotechnology Co., Ltd., and sodium chloride injection was purchased from Shijiazhuang No.4 Medicine Co., Ltd., sodium pentobarbital was purchased from Beijing Chemical Reagent Company.

[0071] 1.2 Experimental animals

[0072] Mice are SPF grade ICR mice, weighing about 30 g, male, purchased from Beijing Weitong Lihua Experimental Animal Co., Ltd. The mice were raised in an SPF grade animal room, fed with full-price nutritional feed regularly, at a room temperature of 25° C. to 30° C., and a humidity of 50% to 70%.

[0073] 2. Experimental method

[0074] 2.1 Effects of isorosmarinic acid on sleep time of mice induced by suprathreshold dose of pentobarbital sodium

[0075] Take 40 m...

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Abstract

The invention discloses a compound as shown in formula (I) and the application of a prodrug or medicinal salt thereof in preparing drugs with a function of improving sleeping action, wherein R1, R2 and R3 are independently selected from hydrogen atoms, C1-C6 alkyl groups, C2-C6 alkyl groups, C3-C6 hetero alkyl groups, C3-C6 cycloalkyl groups or C1-C6 alkoxyl groups.

Description

technical field [0001] The present invention relates to the use of a compound, especially the use for preparing medicine for improving sleep. Background technique [0002] Isorrosmarinic acid (Salviaflaside) is a phenolic acid compound, which has been reported to have antibacterial, antiviral, antioxidant, anti-inflammatory, immunosuppressive, antithrombotic and other pharmaceutical activities. In addition, it is also reported that the compound has a good inhibitory effect on breast cancer cells. Wu Yuanzhao et al. ("The Effect and Mechanism of Isorosmarinic Acid in Inducing Breast Cancer Cell Apoptosis", Chinese Journal of Surgery of Integrated Traditional Chinese and Western Medicine, Issue 06, 2018, Pages 749-753) reported that isosamarinic acid Glycosides can mediate the apoptosis of breast cancer cells. CN105017345A discloses a mixture of isorosmarinic acid, rosmarinic acid, isorosmarinic acid methyl ester and rosmarinic acid methyl ester, wherein isorosmarinic acid, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7034A61P25/20
CPCA61K31/7034A61P25/20
Inventor 王雪茜姜艳艳程发峰邱俊娜张双马重阳樊姝宁邓楠刘斌
Owner BEIJING UNIV OF CHINESE MEDICINE
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