Traditional Chinese medicine composition for regulating reverse cholesterol transport and application of composition

Abstract

The invention relates to a traditional Chinese medicine composition for regulating reverse cholesterol transport. The traditional Chinese medicine composition is prepared from, by weight, 30 parts ofraw radix astragali, 20 parts of radix salviae miltiorrhizae, 15 parts of trichosanthes kirilowii maxim and 12 parts of leeches. The invention also provides application of the traditional Chinese medicine composition. The traditional Chinese medicine composition directly acts on an LXRalpha-SREBP1-ABCA1/G1 signal channel in arterial blood vessel macrophage, and further influences and reverses cholesterol efflux on the surface of the macrophage, so that the function of preventing generation and development of ASCVD is achieved. Clinical experiments verify that the traditional Chinese medicine composition can inhibit formation of plaques, improve the properties of plaques and improve the blood lipid condition of a patient, the side effect on the liver and kidneys is small, the safety is high, and atherosclerosis can be effectively treated; the number of raw material components is small, the cost is low, the method is simple, the curative effect is obvious, toxic and side effects are avoided, and the traditional Chinese medicine composition is easy to accept by the patient.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for regulating cholesterol reverse transport and its application. Background technique [0002] Atherosclerosis (AS) is a common and important one in a group of vascular diseases called arteriosclerosis, and the appearance of lipid accumulated in the arterial intima is yellow atheroma. Lipid metabolism disorder is the basis of atherosclerotic lesions, which is characterized by the involvement of arterial lesions starting from the intima, usually with accumulation of lipids and complex carbohydrates, hemorrhage and thrombosis, followed by fibrous tissue hyperplasia and calcium deposition, and then There is gradual degeneration and calcification of the arterial media, resulting in thickening and hardening of the arterial wall and narrowing of the vascular lumen. Lesions often involve large and medium muscular arteries...

AI Technical Summary

Problems solved by technology

However, there is no report about the traditional Chinese medicine composition of the present inventio

Images