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Novel cefazolin sodium compound as well as composition and application thereof

A technology of cefazolin sodium and compounds, applied in the field of medicine, to achieve the effects of reducing manufacturing costs and costs, improving operability, and facilitating storage and transportation

Pending Publication Date: 2019-07-23
刘力
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] So far, there is no published bibliography at home and abroad to report the novel cefazolin sodium compound of the present invention with better stability, such as cefazolin sodium κ-type crystalline compound, cefazolin sodium ν-type crystalline compound, cefazolin sodium ω-type crystalline compound, i.e. new cefazolin sodium crystalline hydrate with different molecular formulas or different crystalline forms and its preparation method and use

Method used

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  • Novel cefazolin sodium compound as well as composition and application thereof
  • Novel cefazolin sodium compound as well as composition and application thereof
  • Novel cefazolin sodium compound as well as composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 3

[0108] Embodiment 3 (attached Figure 4 ) Corresponding data of powder X-ray diffraction pattern:

[0109] Peak Search Report (34Peaks, Max P / N=16.3)

[0110] PEAK: 19-pts / Parabolic Filter, Threshold=3.0, Cutoff=0.1%, BG=3 / 1.0, Peak-Top=Summit

[0111]

[0112]

Embodiment 6

[0113] Embodiment 6 (attached Figure 15 ) Corresponding data of powder X-ray diffraction pattern:

[0114] Peak Search Report (15Peaks, Max P / N=16.5)

[0115] PEAK: 21-pts / Parabolic Filter, Threshold=3.0, Cutoff=2.0%, BG=3 / 1.0, Peak-Top=Summit

[0116]

Embodiment 7

[0117] Embodiment 7 (attached Figure 17 ) Corresponding data of powder X-ray diffraction pattern:

[0118] Peak Search Report (34Peaks, Max P / N=17.2)

[0119] PEAK: 17-pts / Parabolic Filter, Threshold=3.0, Cutoff=2.0%, BG=3 / 1.0, Peak-Top=Summit

[0120]

[0121]

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PUM

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Abstract

The invention discloses a novel cefazolin sodium compound with lower moisture absorption, better storage stability and the like, composition of the compound and an application of the compound in preparation of drugs for treating or preventing respiratory tract infection of human or animals due to gram positive or negative bacterial sensitive bacteria, endocarditis, peritonitis, pyelonephritis, urinary tract infection, septicemia and infection of bone, joints, skin and soft tissue.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to provide a novel compound with better stability of the antibacterial drug cefazolin sodium, a pharmaceutical composition thereof, a preparation method and application thereof. Background technique [0002] The antibacterial spectrum of cefazolin sodium is similar to that of cephalexin. It is effective against Staphylococcus (including enzyme-producing strains), Streptococcus (except Enterococcus), Streptococcus pneumoniae, Escherichia coli, Proteus mirabilis, Klebsiella, Haemophilus influenzae and producing Enterobacter aerogenes have antibacterial effect. It is characterized by a strong effect on Gram-negative bacteria and weak resistance to Staphylococcus β-lactamase. Usually used for injection. After intramuscular injection of 1g, the blood concentration in 1 hour is 64μg / ml; in intravenous injection of 1g, the blood concentration in 30 minutes is 106μg / ml. The half-life is...

Claims

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Application Information

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IPC IPC(8): C07D501/36C07D501/04C07D501/12A61K31/546A61K45/06A61P31/04
CPCA61K45/06C07B2200/13C07D501/04C07D501/12C07D501/36
Inventor 刘力
Owner 刘力
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