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Application of rutabaga in preparation of drug for protecting liver

The technology of a medicine and mangosteen, which is applied in the field of use of mangosteen in the preparation of liver-protecting medicines, can solve problems such as unreported, and achieve the effects of reducing apoptosis, improving antioxidant capacity, and being widely used.

Active Publication Date: 2019-08-02
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] After consulting the literature, there is no report on the liver protection of Manjing

Method used

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  • Application of rutabaga in preparation of drug for protecting liver
  • Application of rutabaga in preparation of drug for protecting liver
  • Application of rutabaga in preparation of drug for protecting liver

Examples

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Embodiment 1

[0024] 1 material

[0025] 1.1 Experimental animals

[0026] Kunming mice, SPF grade, male, 18±22g, provided by Chengdu Dashuo Biotechnology Co., Ltd., license number: SCXK (Sichuan) 2013-24.

[0027] 1.2 Drugs and reagents

[0028] Manjing, a Tibetan medicine, was purchased from Maerkang County, Aba Prefecture, Sichuan Province. It was identified as the root tuber of Brassica rapa Linn. by Zhang Yi, a researcher at Chengdu University of Traditional Chinese Medicine. Bifendate dripping pills were purchased from Beijing Union Pharmaceutical Factory; mandarin polysaccharides were self-made in the laboratory; carbon tetrachloride was purchased from Chengdu Kelong Chemical Reagent Factory, batch number: 2010061. Malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and Coomassie brilliant blue kits were purchased from Nanjing Jiancheng Bioengineering Institute. IL-1β, IL-6, and TNF-α were purchased from SRB. The BCA protein concentration determina...

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Abstract

The invention provides application of rutabaga in preparation of a drug for protecting liver. Found by action mechanism research, a Tibetan medicine rutabaga polysaccharide can improve the antioxidantcapacity of the liver of a CCl4-induced acute liver injury mouse model, and significantly reduce the oxidative damage of the liver, can inhibit the expression of caspase3 protein in the liver of a CCl4-induced acute liver injury mouse, reduces the apoptosis of hepatocytes, and has a protective effect on CCl4-induced acute liver injury of the mouse. In terms of liver protection, rutabaga polysaccharide has both the prevention and treatment effects, and has a good curative effect, is highly safe and is widely applied.

Description

technical field [0001] The present invention relates to the use of mandarin greens in the preparation of medicines for protecting the liver. Background technique [0002] Tibetan medicine Manjing is the dry tuber of Brassica rapa Linn., which is harvested in autumn when the tubers are ripe. In Tibetan medicine, Manjing is also known as "Niu Ma" ("Four Medical Codes"), and Tibet is commonly known as "Manjing", "Yuangen" or "Giant Root". The traditional theory of Tibetan medicine believes that the root of Manjing root "dispels wind, gives birth to Chiba", nourishes, detoxifies, cures "bacon disease", "dragon disease", weakness, poisoning disease", and cures "various poisoning diseases, "dragon" disease, Weakness of the body", modern research shows that the extract of Manjing has anti-hypoxia, immunity-enhancing, anti-radiation and other activities. Turnip is rich in polysaccharides, and the antioxidant effect of polysaccharides has been proved to be an important mechanism fo...

Claims

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Application Information

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IPC IPC(8): A61K36/31A61K31/715A61P1/16
CPCA61K31/715A61K36/31A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2236/55A61P1/16
Inventor 邝婷婷范刚张艺杨海玲李秋月
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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