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A biomarker for the diagnosis of asthenozoospermia

A technique for asthenozoospermia and spermatozoa, applied in the field of biomarkers for the diagnosis of asthenozoospermia, which can solve problems such as undeveloped and clinical use

Active Publication Date: 2022-04-12
江西省妇幼保健院
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Problems solved by technology

So far, biomarkers for the diagnosis of asthenozoospermia have not been developed and used clinically. Therefore, it is urgent to study the pathogenic mechanism of asthenospermia more deeply, find new proteins related to asthenospermia, and promote the prevention and treatment of asthenospermia. Understanding the mechanism, finding the cause of male infertility from the molecular level, truly achieving the trinity of diagnosis, treatment and prevention, and providing precise and individualized treatment for male infertility patients

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  • A biomarker for the diagnosis of asthenozoospermia
  • A biomarker for the diagnosis of asthenozoospermia

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Embodiment 1

[0054] The TDRG1 content in the sperm of 27 normal people and 25 cases of asthenozoospermia was screened, and the TDRG1 content and forward motility rate of the normal and diseased groups obtained by relative quantitative analysis were analyzed by linear regression. The results are as follows: figure 1 (r2=0.7463, Pfigure 1 ), figure 2 shown. figure 1 In , TDRG1 content was found to be positively correlated with forward locomotor rate. figure 2 Among them, the lowest relative content of TDRG1 in normal human sperm was 0.32.

[0055]Therefore, the expression of TDRG1 in sperm has a high correlation with asthenospermia, and can be used as a biomarker for the diagnosis of asthenospermia. Specifically, asthenospermia with the relative content of TDRG1 lower than 0.32 can be defined as TDRG1 Asthenozoospermia with decreased content.

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Abstract

The invention provides a biomarker for diagnosing asthenozoospermia, which belongs to the technical field of biomedicine and molecular diagnosis. The biomarker is TDRG1, and the Uniprot sequence number is Q3Y452. The expression level of TDRG1 is significantly down-regulated in spermatozoa of asthenozoospermia, and can be applied to the preparation of medicines capable of diagnosing infertility caused by asthenospermia.

Description

technical field [0001] The invention belongs to the technical field of biomedicine and molecular diagnosis, and in particular relates to a biomarker for diagnosing asthenozoospermia. Background technique [0002] Asthenospermia (asthenospermia) refers to a disease in which the proportion of forward motile sperm in semen parameters is less than 32%, and is one of the main causes of male infertility. There are many reasons for low sperm motility, including external environment, self-deficiency and genetic factors, but the specific pathogenesis of asthenospermia is unknown, which seriously hinders the progress of clinical diagnosis and treatment of asthenospermia. It has been reported that the decrease of testis-specific protein content is related to the pathogenesis of asthenozoospermia. So far, biomarkers for the diagnosis of asthenozoospermia have not been developed and used clinically. Therefore, it is urgent to study the pathogenic mechanism of asthenospermia more deeply,...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/68G01N27/447G01N21/76
CPCG01N33/689G01N27/447G01N21/76
Inventor 陈厚仰汤育新曾旭辉罗韬孙捷王共先
Owner 江西省妇幼保健院
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