Novel tumor marking method

A tumor labeling and labeling technology, applied in the field of biomedicine, can solve the problem of low broad-spectrum, and achieve the effect of strong broad-spectrum, high novelty, and high sensitivity

Inactive Publication Date: 2019-09-17
北京健平金星医疗器械有限公司
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Problems solved by technology

[0004] At present, the main method for tumor labeling is to detect the markers of specific tumors, but each detection of this method can generally only target one or several tumors, and the broad spectrum is low.

Method used

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Embodiment Construction

[0023] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some of the embodiments of the present invention, not all of them. Based on The embodiments of the present invention and all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0024] A new tumor labeling method, achieved by labeling vascular endothelial growth factor VEGF with radioactive iodine 131, 131 I-labeled VEGF antibody was performed by the chloramine-T method. Specifically include the following steps:

[0025] 1) Prepare chloramine T solution and Na with PB solution 2 S 2 o 5 solution. Take a certain amount of VEGF antibody in the EP tube and place it in a refrigerator at 4°C; add a certain amount of Na ...

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Abstract

Provided is a novel tumor marking method. By marking a vascular endothelial growth factor (VEGF) with radioactive iodine 131, 131I marking of VEGF antibodies is conducted through a chloramine-T method, and PB liquid is used for preparing chloramine-T solution and Na2S2O5 solution. A certain amount of VEGF antibodies are taken and placed in an EP tube, and the EP tube is placed in a refrigerator of 4 DEG C; a certain amount of Na131I solution, PB liquid and chloramine-T solution are added to the EP tube successively; obtained solution is immediately stirred through an electromagnetic stirrer for a while; 100 ml Na2S2O5 solution is quickly added to terminate the reaction. According to the novel tumor marking method, the vascular endothelial growth factor (VEGF) is marked with radioactive iodine 131, 131I marking of VEGF antibodies is conducted through a chloramine-T method, and the method is simple, convenient, accurate and efficient.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a new tumor marking method. Background technique [0002] Studies have confirmed that when a tumor is larger than 2 mm, it mainly transports sufficient nutrients and removes metabolic waste through new blood vessels, and facilitates its metastasis. Angiogenesis requires the participation of various factors, among which the vascular endothelial growth factor signaling pathway is the main rate-limiting link. . [0003] Vascular endothelial growth factor (VEGF) is a highly specific growth factor for promoting vascular endothelial cells, which can promote endothelial cell proliferation, promote angiogenesis, increase vascular permeability, and change extracellular matrix. It can regulate tumor angiogenesis by binding to VEGF antibody distributed on the surface of tumor vascular endothelium. Participate in the pathogenesis and progression of many angiogenesis-dependent diseases,...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K51/08A61K101/02
CPCA61K51/08
Inventor 邹检平
Owner 北京健平金星医疗器械有限公司
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