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Gel dressing for wound care and preparation method thereof

A technology of wound care and gel, which is applied in the field of gel dressing for wound care and its preparation, to achieve the effects of promoting wound healing, shortening the required time, and relieving pain

Active Publication Date: 2019-09-20
张贤慧
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Abietin-type diterpenoids are a class of diterpenoids with a tricyclic structure, because they have a wide range of physiological activities, such as antibacterial, anti-virus, anti-tuberculosis, hypoglycemic, anti-oxidation, protection of vascular endothelial cells, anti-inflammatory Cancer, inhibition of neuritis, etc., so it has become an excellent lead compound, used in the development of various types of drugs, but there is no report on the application of abietane diterpenoids in promoting wound healing

Method used

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  • Gel dressing for wound care and preparation method thereof
  • Gel dressing for wound care and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1: A kind of gel dressing for wound care

[0026] Compound 1 10g, 10g of chitosan with deacetylation degree of 92%, average molecular weight of 55000, 2g of carbomer, appropriate amount of acetic acid, appropriate amount of NaOH, and appropriate amount of purified water were prepared according to the following method:

[0027] (1) Preparation of the drug layer: add compound 1 and carbomer to 80 mL of purified water, add chitosan after fully swelling, adjust the pH of the solution to 3.5-4.5, stir until the chitosan is completely dissolved, add purified water to 100 mL , use NaOH to adjust the pH of the solution to 6.5-7.5, pour the solution into a mold for molding, and obtain the drug layer of the gel dressing for wound care;

[0028] (2) Prepare the dressing: attach the drug layer to the backing layer, sterilize, and subpackage to obtain the gel dressing for wound care of the present invention.

Embodiment 2

[0029] Embodiment 2: A kind of gel dressing for wound care

[0030] 15g of compound 2, 12g of chitosan with a deacetylation degree of 92%, average molecular weight of 55000, 2g of carbomer, appropriate amount of acetic acid, appropriate amount of NaOH, and appropriate amount of purified water were prepared according to the method in Example 1.

Embodiment 3

[0031] Embodiment 3: A kind of gel dressing for wound care

[0032] Compound 3 8g, 10g of chitosan with deacetylation degree of 86%, average molecular weight of 40000, 2g of carbomer, appropriate amount of acetic acid, appropriate amount of NaOH, appropriate amount of purified water, prepared according to the method in Example 1.

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PUM

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Abstract

The invention relates to a gel dressing for wound care and a preparation method thereof. The gel dressing for wound care comprises abietane diterpenes, and has excellent effect in promoting wound healing; especially, a combination of a compound 1 and a compound 3 can effectively shorten the time needed for wound healing, reduce secondary infection of wounds, and can be widely applied to treatment of ordinary wounds or traumatic wounds with self-healing difficulties, such as diabetic foot, burns and scalds.

Description

technical field [0001] The invention belongs to the field of medicines, and in particular relates to a gel dressing for wound care and a preparation method thereof. Background technique [0002] Trauma mainly refers to damage to the skin, muscles, bones and tissues caused by factors such as external force injury, chemical injury, electric injury, burn, frostbite, and insect bites. With the help of the self-healing ability of human skin and tissues, some minor traumas can gradually heal themselves without treatment or after simple disinfection treatment, but for serious traumas, due to the long time required for self-healing and the long-term contact of the wound with the outside world, it can Secondary causes bacterial or fungal infection, which can cause wound ulceration, serious systemic infection, gas gangrene, tetanus, etc., which not only further prolongs the time required for self-healing of the wound, but also increases the pain of the patient, and even endangers the ...

Claims

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Application Information

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IPC IPC(8): A61L15/44A61L15/42A61L15/20A61K31/58A61K31/122A61K9/70A61P17/02
CPCA61K9/703A61K31/122A61K31/58A61L15/20A61L15/42A61L15/44A61L2300/216A61L2300/412A61P17/02
Inventor 张贤慧李娜宋学琴
Owner 张贤慧
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