Animal model of coronary arteriosclerotic cardiopathy, construction method and application

Abstract

The invention discloses an animal model of a coronary arteriosclerotic cardiopathy, a construction method and application. High-fat and high-cholesterol feed is combined with forage to feed rabbits of6 to 8 months old, and the animal model of the coronary arteriosclerotic cardiopathy is successfully established. The pathological process and pathological changes of the early coronary arteriosclerotic cardiopathy are represented through model, and the model can be used for etiological and pathological research and pharmaceutical evaluation of the coronary arteriosclerotic cardiopathy.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to an animal model of coronary heart disease, a construction method, and an application. Background technique [0002] Metabolic syndrome (MS) is a pathological state of abnormal aggregation of various metabolic components, mainly manifested as: abdominal obesity or excess body mass, dyslipidemia, hypertension, insulin resistance and / or abnormal glucose tolerance, these metabolic disorder syndromes are cardiovascular High risk factors for disease and type 2 diabetes. In 2018, China's big health data revealed that my country's obese population reached 325 million, of which the obesity rate of children and adolescents accounted for 30%, and this figure will double in the next 20 years, reaching 650 million. The incidence of fatty liver in obese children and adolescents reaches 40-50%. In obese children and adolescents, these metabolic abnormalities also exist and become popular, an...

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Problems solved by technology

Under the existing technology, it is still impossible to establish animal models of coronary heart disease in small animals

At present, there is no experimental animal model of coronary heart disease in large animals

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