Animal model of coronary arteriosclerotic cardiopathy, construction method and application

A coronary arteriosclerosis, animal model technology, applied in the medical field, can solve the problems of not seeing coronary arteriosclerosis heart disease, not being able to establish an animal model of coronary arteriosclerosis heart disease in small animals, etc., achieving good stability and no death rate effect

Inactive Publication Date: 2019-10-11
江苏珂玛麒生物科技有限公司
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  • Application Information

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Problems solved by technology

Under the existing technology, it is still impossible to establish animal models of coronary heart disea...

Method used

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  • Animal model of coronary arteriosclerotic cardiopathy, construction method and application
  • Animal model of coronary arteriosclerotic cardiopathy, construction method and application
  • Animal model of coronary arteriosclerotic cardiopathy, construction method and application

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Embodiment Construction

[0033] The specific steps of the present invention are illustrated below through the examples, but not limited by the examples.

[0034] The terms used in the present invention, unless otherwise specified, generally have the meanings commonly understood by those skilled in the art.

[0035] The present invention will be further described in detail below in conjunction with specific examples and with reference to data. It should be understood that this example is only to illustrate the present invention, but not to limit the scope of the present invention in any way.

[0036] In the following examples, various procedures and methods not described in detail are conventional methods well known in the art.

[0037] The present invention will be further described below in conjunction with specific examples.

[0038] Animals: Male SPF grade New Zealand experimental white rabbits, 7 months old, raised in a normal grade animal breeding center, 12 hours of light / 12 hours of no light,...

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Abstract

The invention discloses an animal model of a coronary arteriosclerotic cardiopathy, a construction method and application. High-fat and high-cholesterol feed is combined with forage to feed rabbits of6 to 8 months old, and the animal model of the coronary arteriosclerotic cardiopathy is successfully established. The pathological process and pathological changes of the early coronary arteriosclerotic cardiopathy are represented through model, and the model can be used for etiological and pathological research and pharmaceutical evaluation of the coronary arteriosclerotic cardiopathy.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to an animal model of coronary heart disease, a construction method, and an application. Background technique [0002] Metabolic syndrome (MS) is a pathological state of abnormal aggregation of various metabolic components, mainly manifested as: abdominal obesity or excess body mass, dyslipidemia, hypertension, insulin resistance and / or abnormal glucose tolerance, these metabolic disorder syndromes are cardiovascular High risk factors for disease and type 2 diabetes. In 2018, China's big health data revealed that my country's obese population reached 325 million, of which the obesity rate of children and adolescents accounted for 30%, and this figure will double in the next 20 years, reaching 650 million. The incidence of fatty liver in obese children and adolescents reaches 40-50%. In obese children and adolescents, these metabolic abnormalities also exist and become popular, an...

Claims

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Application Information

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IPC IPC(8): A01K67/027A61K49/00
CPCA01K67/027A01K2207/25A01K2227/107A01K2267/0375A61K49/0008
Inventor 庄永杰吴培灿邢柳柳陈继巧姜世浩邓志豪甘婷沈红英靳策
Owner 江苏珂玛麒生物科技有限公司
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