38 results about "Pathology study" patented technology

A computer-based method and apparatus to facilitate the exchange of pathology studies for the purpose of providing a primary or secondary pathological diagnosis. A study consists of one or more lower-resolution images, the references to the corresponding higher-resolution images, associated image metadata, study metadata and patient metadata. The studies are exchanged from one organization (hospital, practice, or individual physician) to another organization through a set of interconnected dispatcher services. In a cloud model, a plurality of dispatchers may be connected through a Global Dispatcher, both facilitating the addition of new organizations to the cloud and allowing for the addressing of studies from any organization in the cloud to any organization, group or individual in the cloud. By this means, the originating organization may obtain the desired level of care through the selection of recipient organizations, groups and individuals according to the organization's existing criteria. Efficiency in diagnosis is improved through the addressing of a study to a plurality of qualified recipients, as the first recipient with an appropriate, available resource may review and provide a diagnosis for the study.

Disclosed is a mutant human α-synuclein with decreased ability of forming aggregation. The mutant human α-synuclein of the invention is able to inhibit aggregation of the wild type human α-synuclein, Ala53Thr mutant human α-synuclein or Ala50Pro mutant human α-synuclein, thus is useful for investigation of pathology and treatment of Parkinson's disease and for research and development of gene therapy. Also disclosed is a partial structure peptide of human α-synuclein comprising amino acid substitutions as taught by the invention.

The invention provides a lesion tissue growth monitoring method and system. The method includes the steps that inductive shear waves for deformation of a lesion tissue area are acquired, and an elastic image of lesion tissue is acquired according to the inductive shear waves; point-by-point matching is performed for an ROI area of the elastic image, pixel points in the area are tracked, and an elastic information image of the ROI area is constructed; the hardness attribute of the lesion tissue in the elastic information image is determined; the infiltration degree of the elastic information image is tracked, and the range of the infiltration tissue area is determined; the infiltration growth characteristic parameters of the lesion tissue are acquired according to the elastic information image, the hardness attribute and the infiltration tissue area range; the growth of the lesion tissue is monitored according to the infiltration growth characteristic parameters of the lesion tissue. Through the technical scheme, elastic information of the lesion tissue can be represented completely, the benign / malignance mass classification precision is high, the tumor growth monitoring accuracy is high, and an important basis is provided for pathological research on tumors and early diagnosis and treatment of tumors.

The invention provides a device for controlling interaction of various cells as well as a manufacturing method and application of the device. The device provided in the invention comprises a glass substrate (1) and a polydimethylsiloxane seal (2) with a plurality of grooves, wherein the polydimethylsiloxane seal is attached to the surface of the glass substrate to respectively form a plurality of micro-channels, the glass substrate in each micro-channel can be selectively modified to be a substrate for promoting cell adhesion by incubating extracellular matrix proteins or can be modified to be a cell adhesion-resistant substrate by assembling polyethylene glycol solution or is not modified. The device is simple and easy to operate, can control fixation, all movement and partial movement of various cells to achieve the purpose of arbitrarily controlling various cells, can be used for researching the interaction among various cells, the pathology or the cell biological development and can also be used for screening medicines.

The invention provides a circulating tumor cell separation device adopting combined field flow separation. The circulating tumor cell separation device comprises an upper cover plate, a channel plate and a substrate plate from top to bottom; a two-step separation method comprising the field flow separation and specific molecular affinity identification is adopted, wherein the field flow separation adopts an acoustic surface wave driving mode and a dielectrophoresis driving mode, horizontal cell grouping migration and cell layering in a vertical plane are realized respectively, and erythrocytes are preliminarily separated from other cell populations; a residual leucocyte mixed liquid passes through a cell recognition area, circulating tumor cells are fixed in the recognition area by recognition ligands, and a tumor cell sample is acquired through releasing operation finally. The device can rapidly realize circulating tumor cell separation without marks, has great significance in the aspects of patient's disease diagnosis, therapy monitoring, pathological research and the like, and can be used for a separation process of other cells, macromolecular protein and micro-particles.

The present invention discloses an implicated crime principle and network topological structural feature based recognition method for drug-target interaction. The method comprises: firstly, according to human protein-protein interaction data and drug-target interaction data, constructing a drug-target interaction group network which comprises a protein-protein interaction sub-network, a drug-target interaction sub-network and a drug-drug relationship sub-network; according to information of a protein primary structure descriptor, a fingerprint feature of drug molecules and the reliability of interaction, weighting nodes and edges in the network; proposing a new network topological structural feature for characterizing a drug-target interaction pair based on an implicated crime principle and a graph theory; and finally, constructing a model by using a random forest algorithm and predicting a potential drug-target interaction effect in a proteome scale. The method does not require information of three-dimensional structures and the like of protein and drug molecules, is simpler, quicker and more accurate, and has high potential for application to the fields of new drug research and development, pathological study and the like.

The invention discloses a traditional Chinese medicine composite for protecting livers and preventing liver injury and a preparation method and application thereof. The composite comprises the following bulk drugs in parts by weight: 20-30 parts of astraglus base, 10-15 parts of bighead atractylodes rhizome, 10-15 parts of tuckahoe, 10-15 parts of liquorice and 10-15 parts of Schisandra chinensis. The preparation method comprises the following steps of: adding water to the bulk drugs in percentage by weight and decocting, and concentrating until the concentration is equivalent to 0.55-0.75g.ml-1 which is the concentration of crude drugs. Proved by animal experiment pathological study, the spleen-tonifying and liver-protecting prescription of the invention does not have hepatotoxicity per se and has a certain function of preventing mice acute liver injury caused by CCl4. The prescription not only can relieve the liver injury of jasmine on normal mice but also can assist routine dosage of jasmine to prevent the mice acute liver injury caused by CCl4. The invention is safe and effective and has low price and is suitable for patients with chemical and medicament liver injury.

A probe device for use in a tissue inspection system is presented. The probe device comprises a probe body and a control unit at least partially incorporated in the probe body. The probe body carries at least a tissue characterization unit operable for providing sensing data indicative of at least one tissue property at measurement locations in the tissue portion being held by the probe. The control unit comprises: a processor utility for receiving and processing the sensing data and generating measured data indicative of a spatial profile of said at least one tissue property distribution within the tissue portion, and comprises at least one of the following: an imaging utility for receiving said measured data and generating and displaying an image indicative thereof thereby enabling a user to select a region of said tissue portion for further analysis; and a pattern generator module configured for receiving and analyzing said measured data and determining a pattern indicative of an arrangement of regions in said tissue portion, thereby enabling selection of at least one of the regions for further analysis.

Nosologic classification of diseases is accessible on line in a computer system. A computer data base has records of discriminating features, consistent features and variable features of known afflictions. The features are in classification domains which include a phenomenologically classified domain, classified by listing commonly agreed on observations and distinguishing between entities based on these observations. Other classification domains are anatomically classified, pathologically classified by the gross of microscopic pathologic anatomy, revealed by either traditional pathologic study or imaging. One of the classification domains is pathophysiologically, by demonstrating altered chemical or electro physiological parameters. At least one of the classification domains is classified ethiologically by cause.

The invention discloses application of pigeon pea ketonic acid A in terms of preparation of medicines for accompanied diseases of diabetes mellitus or hyperlipidaemia. Animal experiment data show that the pigeon pea ketonic acid A can remarkably reduce the serum triglyceride level, the total cholesterol level and the low-density lipoprotein cholesterol level of SD (Sprague-Dawley) rats with type-2 diabetes mellitus, and can treat or improve the hyperlipidaemia as an accompanied disease of the diabetes mellitus; and pathological research results prove that the pigeon pea ketonic acid A can reduce spotty necrosis of hepatocytes, can treat or improve liver injury as an accompanied disease of the diabetes mellitus, reverses injury to tissues of pancreas inlets of the rats due to glucoses, and has protection and repair effects on pancreas. The pigeon pea ketonic acid A can remarkably reduce the serum triglyceride level and the total cholesterol level of Zucker rats with congenital obesity, and is proved to be capable of treating or improving the hyperlipidaemia.

The invention relates to an immunoenzymatic method for the quantification of protein CETP in plasma, which requires the utilization of fusion protein GST / CETP, the synthetic peptide CETP 11486-S496 and polyclonal antibody anti-CEPT 11486-S496. The method is used in the study of pathologies involving alterations in the CETP levels in plasma or in seric lipids and makes it possible to detect, evaluate and follow-up patients suffering from dyslipidemia and / or risk of altergenesis.

The invention discloses a method for building three-dimensional analog brain development models on the basis of micro-fluidic chips. The method includes main steps of preparing the micro-fluidic chips; forming embryoid bodies (EBs); differentiating and developing analog brains in the micro-fluidic chips. The method has the advantages that the novel engineered three-dimensional analog brain development models can be built by the aid of the method and are micro-reactors with perfusion functions on the basis of micro-fluidic chip technologies; in-vivo brain development basic principles and engineering technologies are combined with one another, and brain early development micro-environments can be effectively simulated; the method is low in cost and reagent dosage and easy to operate, in-situtracking and real-time monitoring can be carried out, animal models and the traditional two-dimensional culture modes can be replaced, brain early development can be simulated to a certain extent, apowerful novel platform can be provided to the aspects such as in-vitro brain development simulation, pathological research on abnormal neural development, medicine screening and toxicity detection, and the like.

The present invention refers to new derivatives of the penta-1,4-dien-3-ones, as well as their processes of preparation. These compounds present strong antitumoral activity and promising antiparasitic action, behaving as almost atoxic by laboratory assays and also by hystopathologic studies. The present invention refers also to a pharmaceutical composition including the referred compounds, method of treatment for cancer and parasitic diseases.

A method for localizing and quantifying S1R role in nociceptive processing; for providing a guide to providing an analgesic therapy; of using an S1R selective ligand as a biomarker for pathphysiological study of memory deficits and cognitive disorders; or of detecting increased S1R density at the site of nerve injury arising from neuropathic pain comprising using as a probe at least one SR1 selective compound or radioligand of the general formula III′, or IV′:

The invention provides a compound and a preparation method and application thereof. The compound serves as a fluorescent probe and can selectively recognize G-quadruplex DNA, and compared with fluorescent probes with similar functions, the probe has the advantages of being high in selectivity, low in biotoxicity, good in membrane permeability, high in color development, good in re-dyeing compatibility and relatively high in light stability. It is indicated that the probe has a wide application range as the G-quadruplex DNA and nucleolus fluorescent probe and is expected to be developed into asimple and visual biological detection reagent related to G-quadruplex DNA and nucleoli and used for physiological and pathology research. The experiment result shows that the compound serves as the fluorescent probe, a fluorescence image marked by the probe has obvious red light distribution when displayed in a cytoplasm and nucleuse area, and it shows that the probe can be used for recognizing specific imaging cytoplasm in living cells and G-quadruplex DNA in the nucleoli.

The invention provides a nucleic acid dye compound and a preparation method and application of the nucleic acid dye compound. The provided compound, as a fluorescence probe, can selectively recognizeG-quadruplex DNA and RNA; compared with the fluorescence probe having similar functions, the probe has the characteristics of strong selectivity, low bio-toxicity, good membrane permeability, strong developing, good counterstaining compatibility, and stronger light stability, and the characteristics indicate that the compound has extensive applications as the G-quadruplex DNA and the nucleolus fluorescence probe, and is expected to be developed into a simple convenient intuitive biological detection agent for the related physiological and pathological studies of the G-quadruplex DNA and nucleolus.

The invention discloses a construction method of an animal model of the child and adolescent metabolic syndrome. A phased feeding mode is used, common maintenance feed, high-fat high-cholesterol feedand forage are used, and white rabbits which are 6-8 weeks old (child stage) are bred, so that the animal experiment model of the child and adolescent metabolic syndrome is successfully built. The model simultaneously has symptoms of early coronary heart disease, atherosclerosis, fatty liver and non-alcoholic fatty hepatitis and liver fibrosis, proteinuria nephrosis and the like caused by the metabolic syndrome, and can be used for etiological and pathological research and pharmaceutical evaluation of the metabolic syndrome and concurrent multi-organ lesions of the metabolic syndrome.

The invention discloses a spring type animal beating device. The spring type animal beating device comprises a base, a fixator and an indication panel and beating parts, wherein the base is connected with the beating part through a screw, the indication panel is composed of a perpendicular panel and a slide panel, and the slide panel is additionally provided with a protractor and transversely slides on the perpendicular panel. The beating parts include a beating rod, a spring and a beating guide rail, and the beating rod moves along the beating guide rail. The invention provides a spring type animal beating method. The spring type small animal beating device can mark different beating forces with angle degrees, by replacing different springs and beating rods, beating of small and medium animals can be realized, injury classification animal beating models can be easily manufactured, and the spring type animal beating type is applicable to researches of biomechanics, injury mechanism and pathology.

The invention provides a system and a method suitable for culturing and real-time monitoring of biological tissue, and relates to the technical field of tissue engineering. The system comprises a biological 3D printer, an organ chip, a connecting base, a drive system and an auxiliary system, wherein the organ chip is connected with the drive system through the connecting base; the biological 3D printer is used for constructing biological 3D printing tissue; the organ chip is used for accommodating a medium and the biological 3D printing tissue and culturing the biological 3D printing tissue; the connecting base is used for accommodating the organ chip and connected with the drive system; the drive system is used for driving the medium to flow in the organ chip; the auxiliary system is usedfor monitoring the state of the biological 3D printing tissue. According to the system and the method, one novel culture platform is provided for works such as tissue culture, pathological research,drug screening and the like.

The invention discloses an animal model of a coronary arteriosclerotic cardiopathy, a construction method and application. High-fat and high-cholesterol feed is combined with forage to feed rabbits of6 to 8 months old, and the animal model of the coronary arteriosclerotic cardiopathy is successfully established. The pathological process and pathological changes of the early coronary arteriosclerotic cardiopathy are represented through model, and the model can be used for etiological and pathological research and pharmaceutical evaluation of the coronary arteriosclerotic cardiopathy.

The invention relates to the technical field of medical treatment and especially relates to a method for making a rat unilateral pulmonary fibrosis model. The method comprises animal anesthetization, tracheal intubation, bleomycin perfusion into unilateral lung, and postoperative care, wherein concentrations of bleomycin for perfusion into unilateral lung is 1.5, 3.0 and 5.0mg / kg. The method has the advantages of simple making processes, wide popularization range, high experiment setting ratio, stable result, small pathology variation and low mortality. The rat unilateral pulmonary fibrosis model has a pathological process high similar to a human chronic pulmonary fibrosis pathological process and thus the rat unilateral pulmonary fibrosis model has a high etiology and pathology research value and has an important meaning for evaluation of pulmonary fibrosis-resistant drugs.

Application of the pigeon pea ketonic acid A and a pharmaceutically acceptable derivative thereof in preparation of a medicine for a diabetes-accompanying disease or hyperlipidemia as well as a functional health product. The diabetes-accompanying disease is hyperlipidemia, liver damage, kidney damage, or pancreas damage accompanying diabetes.

The invention belongs to the field of the ulcer treatment with a traditional Chinese medicine, and especially relates to a traditional Chinese medicinal composition for treating the oral ulcer, wherein the traditional Chinese medicinal composition is prepared from specific components according to a specific ratio. A technical scheme of the invention is that the composition is prepared by taking 200-450 parts by weight of calcined gypsum, 150-400 parts by weight of dahurian angelica root, 50-300 parts by weight of Bletilla striata, 50-200 parts by weight of unprepared licorice and 20-200 parts by weight of borneol and mixing them to form powder. According to technical scheme, the calcined gypsum has the efficacies of dampness astringing, flesh engendering, sore astringing and bleeding stopping; the dahurian angelica root has the efficacies of bleeding stopping, swelling relieving, pain relieving and pus discharging, and dampness eliminating; the unprepared licorice has the efficacies of heat clearing and detoxifying, pain relieving, various medicine modulating, and medicinal toxicity and strength alleviating; and borneol has the efficacies of heat clearing and pain relieving, inflammation resisting, bacterium resisting and corrosion resisting. The dahurian angelica root and the Bletilla striata are paired as a monarch medicine and a minister medicine; the calcined gypsum and borneol are used as assistant medicines; and the unprepared licorice is used as a guide medicine. The medicines are mixed to become the powder which has the efficacies of vital qi strengthening and toxin expelling, and caries dispelling and flesh engendering and provides a good environment for the ulcer cell regeneration. The study on animal pharmacodynamics and the pathology show that the medicinal composition which can effectively treat the oral ulcer has the advantages of administration calmness, and safety and nontoxicity.