38 results about "Pathology study" patented technology

The invention provides a circulating tumor cell separation device adopting combined field flow separation. The circulating tumor cell separation device comprises an upper cover plate, a channel plate and a substrate plate from top to bottom; a two-step separation method comprising the field flow separation and specific molecular affinity identification is adopted, wherein the field flow separation adopts an acoustic surface wave driving mode and a dielectrophoresis driving mode, horizontal cell grouping migration and cell layering in a vertical plane are realized respectively, and erythrocytes are preliminarily separated from other cell populations; a residual leucocyte mixed liquid passes through a cell recognition area, circulating tumor cells are fixed in the recognition area by recognition ligands, and a tumor cell sample is acquired through releasing operation finally. The device can rapidly realize circulating tumor cell separation without marks, has great significance in the aspects of patient's disease diagnosis, therapy monitoring, pathological research and the like, and can be used for a separation process of other cells, macromolecular protein and micro-particles.

The invention discloses a traditional Chinese medicine composite for protecting livers and preventing liver injury and a preparation method and application thereof. The composite comprises the following bulk drugs in parts by weight: 20-30 parts of astraglus base, 10-15 parts of bighead atractylodes rhizome, 10-15 parts of tuckahoe, 10-15 parts of liquorice and 10-15 parts of Schisandra chinensis. The preparation method comprises the following steps of: adding water to the bulk drugs in percentage by weight and decocting, and concentrating until the concentration is equivalent to 0.55-0.75g.ml-1 which is the concentration of crude drugs. Proved by animal experiment pathological study, the spleen-tonifying and liver-protecting prescription of the invention does not have hepatotoxicity per se and has a certain function of preventing mice acute liver injury caused by CCl4. The prescription not only can relieve the liver injury of jasmine on normal mice but also can assist routine dosage of jasmine to prevent the mice acute liver injury caused by CCl4. The invention is safe and effective and has low price and is suitable for patients with chemical and medicament liver injury.

A computer-based method and apparatus to facilitate the exchange of pathology studies for the purpose of providing a primary or secondary pathological diagnosis. A study consists of one or more lower-resolution images, the references to the corresponding higher-resolution images, associated image metadata, study metadata and patient metadata. The studies are exchanged from one organization (hospital, practice, or individual physician) to another organization through a set of interconnected dispatcher services. In a cloud model, a plurality of dispatchers may be connected through a Global Dispatcher, both facilitating the addition of new organizations to the cloud and allowing for the addressing of studies from any organization in the cloud to any organization, group or individual in the cloud. By this means, the originating organization may obtain the desired level of care through the selection of recipient organizations, groups and individuals according to the organization's existing criteria. Efficiency in diagnosis is improved through the addressing of a study to a plurality of qualified recipients, as the first recipient with an appropriate, available resource may review and provide a diagnosis for the study.

Rapid and specific detection of biological cells and biomolecules is important to biological assays across diverse fields including genomics, proteomics, diagnoses, and pathological studies. Microarrays and microfluidics increasingly dominate such detection techniques due to the ability to perform significant numbers of tests with limited sample volumes. A snap chip assembly is provided for the transfer of a microarray of reagents within semi-spherical liquid droplets on a transfer chip to a target assay microarray on an assay chip following assembly of the two chips and physical contact of the droplets with the target array. Reagents in nanoliter quantities are spotted on both chips and selectively transferred as liquid droplets between transfer chip and assay chip within the contact areas. Using the snap chip structure the inventors performed immunoassays with colocalization of capture and detection antibodies with 10 targets and bead-in-gel droplet microarrays with 9 targets in the low pg / ml regime.

The present invention refers to new derivatives of the penta-1,4-dien-3-ones, as well as their processes of preparation. These compounds present strong antitumoral activity and promising antiparasitic action, behaving as almost atoxic by laboratory assays and also by hystopathologic studies. The present invention refers also to a pharmaceutical composition including the referred compounds, method of treatment for cancer and parasitic diseases.

The invention provides a nucleic acid dye compound and a preparation method and application of the nucleic acid dye compound. The provided compound, as a fluorescence probe, can selectively recognizeG-quadruplex DNA and RNA; compared with the fluorescence probe having similar functions, the probe has the characteristics of strong selectivity, low bio-toxicity, good membrane permeability, strong developing, good counterstaining compatibility, and stronger light stability, and the characteristics indicate that the compound has extensive applications as the G-quadruplex DNA and the nucleolus fluorescence probe, and is expected to be developed into a simple convenient intuitive biological detection agent for the related physiological and pathological studies of the G-quadruplex DNA and nucleolus.

The present invention refers to new derivatives of the penta-1,4-dien-3-ones, as well as their processes of preparation. These compounds present strong antitumoral activity and promising antiparasitic action, behaving as almost atoxic by laboratory assays and also by hystopathologic studies. The present invention refers also to a pharmaceutical composition including the referred compounds, method of treatment for cancer and parasitic diseases.

Application of the pigeon pea ketonic acid A and a pharmaceutically acceptable derivative thereof in preparation of a medicine for a diabetes-accompanying disease or hyperlipidemia as well as a functional health product. The diabetes-accompanying disease is hyperlipidemia, liver damage, kidney damage, or pancreas damage accompanying diabetes.

A method for localizing and quantifying S1R role in nociceptive processing; for providing a guide to providing an analgesic therapy; of using an S1R selective ligand as a biomarker for pathphysiological study of memory deficits and cognitive disorders; or of detecting increased S1R density at the site of nerve injury arising from neuropathic pain comprising using as a probe at least one SR1 selective compound or radioligand of the general formula III′, or IV′:

Nosologic classification of diseases is accessible on line in a computer system. A computer data base has records of discriminating features, consistent features and variable features of known afflictions. The features are in classification domains which include a phenomenologically classified domain, classified by listing commonly agreed on observations and distinguishing between entities based on these observations. Other classification domains are anatomically classified, pathologically classified by the gross of microscopic pathologic anatomy, revealed by either traditional pathologic study or imaging. One of the classification domains is pathophysiologically, by demonstrating altered chemical or electrophysiological parameters. At least one of the classification domains is classified ethiologically by cause.

The invention belongs to the field of the ulcer treatment with a traditional Chinese medicine, and especially relates to a traditional Chinese medicinal composition for treating the oral ulcer, wherein the traditional Chinese medicinal composition is prepared from specific components according to a specific ratio. A technical scheme of the invention is that the composition is prepared by taking 200-450 parts by weight of calcined gypsum, 150-400 parts by weight of dahurian angelica root, 50-300 parts by weight of Bletilla striata, 50-200 parts by weight of unprepared licorice and 20-200 parts by weight of borneol and mixing them to form powder. According to technical scheme, the calcined gypsum has the efficacies of dampness astringing, flesh engendering, sore astringing and bleeding stopping; the dahurian angelica root has the efficacies of bleeding stopping, swelling relieving, pain relieving and pus discharging, and dampness eliminating; the unprepared licorice has the efficacies of heat clearing and detoxifying, pain relieving, various medicine modulating, and medicinal toxicity and strength alleviating; and borneol has the efficacies of heat clearing and pain relieving, inflammation resisting, bacterium resisting and corrosion resisting. The dahurian angelica root and the Bletilla striata are paired as a monarch medicine and a minister medicine; the calcined gypsum and borneol are used as assistant medicines; and the unprepared licorice is used as a guide medicine. The medicines are mixed to become the powder which has the efficacies of vital qi strengthening and toxin expelling, and caries dispelling and flesh engendering and provides a good environment for the ulcer cell regeneration. The study on animal pharmacodynamics and the pathology show that the medicinal composition which can effectively treat the oral ulcer has the advantages of administration calmness, and safety and nontoxicity.

The invention relates to a two-photon fluorescence probe for RNA imaging and an application thereof in living cells. A structural general formula of the probe is shown as (I), wherein R is hydrogen, alkyl group, hydroxyalkyl or ether group, and X is bromine or iodine. The two-photon fluorescence probe provided by the invention is a novel RNA selective recognizing two-photon fluorescence probe; the probe has the characteristics of excellent membrane permeability, strong color development and high light stability; and the two-photon fluorescence probe can be developed into a biological detection reagent for RNA related physiological and pathological research.

The invention provides a device for controlling interaction of various cells as well as a manufacturing method and application of the device. The device provided in the invention comprises a glass substrate (1) and a polydimethylsiloxane seal (2) with a plurality of grooves, wherein the polydimethylsiloxane seal is attached to the surface of the glass substrate to respectively form a plurality of micro-channels, the glass substrate in each micro-channel can be selectively modified to be a substrate for promoting cell adhesion by incubating extracellular matrix proteins or can be modified to be a cell adhesion-resistant substrate by assembling polyethylene glycol solution or is not modified. The device is simple and easy to operate, can control fixation, all movement and partial movement of various cells to achieve the purpose of arbitrarily controlling various cells, can be used for researching the interaction among various cells, the pathology or the cell biological development and can also be used for screening medicines.