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Application of pigeon pea ketonic acid A in terms of preparation of medicines for accompanied diseases of diabetes mellitus and hyperlipidaemia

A technology of tree ketonic acid and diabetes, which is applied in the field of compounds, can solve the problems of restricting the use of drugs and not involving the treatment of diabetic concomitant diseases or hyperlipidemia

Active Publication Date: 2014-04-02
GUANGZHOU YUNZHONG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Since September 2010, Rosiglitazone Maleate, which is widely used, has been recommended to be suspended by the European Medicines Agency, the US Food and Drug Administration and the China State Food and Drug Administration because it may cause heart problems. Those with type 2 diabetes whose blood sugar cannot be controlled by other drugs greatly limit the use of these drugs
In the previous application documents, there was no research involving the treatment of diabetic concomitant diseases or hyperlipidemia

Method used

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  • Application of pigeon pea ketonic acid A in terms of preparation of medicines for accompanied diseases of diabetes mellitus and hyperlipidaemia
  • Application of pigeon pea ketonic acid A in terms of preparation of medicines for accompanied diseases of diabetes mellitus and hyperlipidaemia
  • Application of pigeon pea ketonic acid A in terms of preparation of medicines for accompanied diseases of diabetes mellitus and hyperlipidaemia

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Embodiment Construction

[0019] The present invention will be further described below in conjunction with experiments and experimental data.

[0020] Pharmacodynamic experiment results of stickyronic acid A in SD rat type 2 diabetes animal model

[0021] Animal grouping and drug administration: Male SD rats with diabetes induced by a high-sugar and high-fat diet combined with intraperitoneal injection of small doses of streptozotocin were selected, and were evenly divided into model group, treatment group and positive control group according to fasting blood glucose and body weight. 8 in each group. Another 8 normal rats were followed for observation.

[0022] (1) Model group: equal volumes of mixed Tween-80 and dimethyl sulfoxide were diluted tenfold with distilled water, and injected intraperitoneally at 1 mL per 100 g of body weight, once a day until the end of the experiment.

[0023] (2) Treatment group: Haginonic acid A was dissolved in equal volumes of mixed Tween 80 and dimethyl sulfoxide to...

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Abstract

Application of the pigeon pea ketonic acid A and a pharmaceutically acceptable derivative thereof in preparation of a medicine for a diabetes-accompanying disease or hyperlipidemia as well as a functional health product. The diabetes-accompanying disease is hyperlipidemia, liver damage, kidney damage, or pancreas damage accompanying diabetes.

Description

technical field [0001] The present invention relates to a new application of compounds, in particular to the application of stringyaronic acid A and its pharmaceutically acceptable derivatives, especially the application of stringyaronic acid A and its pharmaceutically acceptable salts or esters in the preparation of drugs for diabetic concomitant disease or hyperlipidemia . Background technique [0002] Hyperlipidemia is the single or multiple levels of total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) in the blood caused by lipid metabolism disorders that are higher than the normal standard. The main harm of hyperlipidemia is to cause atherosclerosis. Arterial blockage causes long-term insufficient blood and oxygen supply to vital organs throughout the body, resulting in organic and functional damage to organs, leading to numerous related diseases. One of the most common fatal diseases is coronary heart disease. Hyperlipidemia is ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/192A61P3/10A61P3/06A23L1/29A23L33/00
CPCA61K31/192A61K36/48A61P1/16A61P1/18A61P3/06A61P3/10A61P13/12
Inventor 沈小玲王璐胡英杰邱声祥符林春麦兆
Owner GUANGZHOU YUNZHONG BIOTECH
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