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Animal model of child and adolescent metabolic syndrome and construction method

A metabolic syndrome and construction method technology, applied in the field of animal models and establishment of metabolic syndrome induced by high fat and high cholesterol in children and adolescents, can solve the problem of one or several diseases in the model, and achieve the relief of indigestion, progress Stable and guarantee the effect of modeling success rate

Active Publication Date: 2019-06-25
凯斯艾生物科技(苏州)有限公司
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  • Abstract
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Problems solved by technology

In the prior art, the method of using high-fat and high-cholesterol feed for modeling is mostly used in the establishment of animal models of non-alcoholic fatty liver disease, atherosclerosis, exogenous hyperlipidemia, etc. However, these models usually only have one symptoms of several diseases

Method used

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  • Animal model of child and adolescent metabolic syndrome and construction method
  • Animal model of child and adolescent metabolic syndrome and construction method
  • Animal model of child and adolescent metabolic syndrome and construction method

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Embodiment Construction

[0047] The specific steps of the present invention are illustrated below through the examples, but not limited by the examples.

[0048] The terms used in the present invention, unless otherwise specified, generally have the meanings commonly understood by those skilled in the art.

[0049] The present invention will be further described in detail below in conjunction with specific examples and with reference to data. It should be understood that this example is only to illustrate the present invention, but not to limit the scope of the present invention in any way.

[0050] In the following examples, various procedures and methods not described in detail are conventional methods well known in the art.

[0051] The present invention will be further described below in conjunction with specific examples.

[0052] Animals: male SPF grade New Zealand experimental white rabbits, 7 weeks old, raised in a general grade animal breeding center, 12 hours of light / 12 hours of no light,...

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Abstract

The invention discloses a construction method of an animal model of the child and adolescent metabolic syndrome. A phased feeding mode is used, common maintenance feed, high-fat high-cholesterol feedand forage are used, and white rabbits which are 6-8 weeks old (child stage) are bred, so that the animal experiment model of the child and adolescent metabolic syndrome is successfully built. The model simultaneously has symptoms of early coronary heart disease, atherosclerosis, fatty liver and non-alcoholic fatty hepatitis and liver fibrosis, proteinuria nephrosis and the like caused by the metabolic syndrome, and can be used for etiological and pathological research and pharmaceutical evaluation of the metabolic syndrome and concurrent multi-organ lesions of the metabolic syndrome.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to an animal model of metabolic syndrome induced by high fat and high cholesterol in children and adolescents and a method for establishing it. Background technique [0002] Metabolic syndrome (MS) is a pathological state of abnormal aggregation of various metabolic components, mainly manifested as: abdominal obesity or excess body mass, dyslipidemia, hypertension, insulin resistance and / or abnormal glucose tolerance, these metabolic disorder syndromes are cardiovascular High risk factors for disease and type 2 diabetes. In 2018, China's big health data revealed that my country's obese population reached 325 million, of which the obesity rate of children and adolescents accounted for 30%, and this figure will double in the next 20 years, reaching 650 million. The incidence of fatty liver in obese children and adolescents reaches 40-50%. In obese children and adolescents, these me...

Claims

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Application Information

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IPC IPC(8): A01K67/02
Inventor 庄永杰杨祖经陈继巧姜世浩靳策沈红英甘婷
Owner 凯斯艾生物科技(苏州)有限公司
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