A kind of animal model and construction method of metabolic syndrome in children and adolescents

Abstract

The invention discloses a method for constructing an animal model of metabolic syndrome in children and adolescents, which adopts a staged feeding method and uses common maintenance feed, high-fat and high-cholesterol feed and forage to feed 6-8-week-old (childhood) animals in combination. Rabbits have successfully established animal experimental models of metabolic syndrome in children and adolescents. The model also has early coronary heart disease, atherosclerosis, fatty liver, non-alcoholic steatohepatitis, liver fibrosis, proteinuric nephropathy and other disease symptoms caused by metabolic syndrome, and can be used for metabolic syndrome and its concurrent diseases. Etiology, pathological research and pharmaceutical evaluation of multiple organ lesions.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to an animal model of metabolic syndrome induced by high fat and high cholesterol in children and adolescents and a method for establishing it. Background technique [0002] Metabolic syndrome (MS) is a pathological state of abnormal aggregation of various metabolic components, mainly manifested as: abdominal obesity or excess body mass, dyslipidemia, hypertension, insulin resistance and / or abnormal glucose tolerance, these metabolic disorder syndromes are cardiovascular High risk factors for disease and type 2 diabetes. In 2018, China's big health data revealed that my country's obese population reached 325 million, of which the obesity rate of children and adolescents accounted for 30%, and this figure will double in the next 20 years, reaching 650 million. The incidence of fatty liver in obese children and adolescents reaches 40-50%. In obese children and adolescents, these me...

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