Triad micro-catheter device and method used for transthoracic and epicardial intramyocardial injection under ultrasound guidance

Abstract

The invention provides a triad micro-catheter device and method used for transthoracic and epicardial intramyocardial injection under ultrasound guidance. The device comprises a thick puncture needle,a micro-catheter and a fine needle core; during puncture, the fine needle core is inserted into the micro-catheter, and air-tight sealing is formed between the fine needle core and the micro-catheter; when a drug is injected, the fine needle core is withdrawn from the micro-catheter, and the second end of the micro-catheter is connected with a drug injection device. According to the device and the method, only 2-3 holes need to be punctured in the chest wall of an experimental animal or a subject every time to inject the drug into the myocardium through the transthoracic epicardium by using the micro-catheter under ultrasound guidance, the influences of heat beating on puncture needle positioning can be overcome, precise drug delivery is achieved, myocardial secondary injury is avoided, and the device has the advantages that the local drug delivery concentration is high, injection positions are accurate and controllable, wounds are small, few complications are caused, and drug delivery can be conducted many times at different times. A convenient, safe and efficient intramyocardial drug delivery mode is provided and has high clinical and translational value.

Description

technical field [0001] The present application relates to the technique of intramyocardial injection of drugs, in particular to a triple microcatheter device and method for transthoracic transepicardial intramyocardial injection under ultrasound guidance. Background technique [0002] Cardiovascular diseases account for about 25% of all human deaths, and various cardiovascular diseases can lead to heart failure, such as myocardial infarction, valvular heart disease, cardiomyopathy, and hypertension. The incidence of adult heart failure is 1-2% in European and American countries, and 0.9-1.3% in my country, showing an upward trend. For patients with heart failure, even if the primary cause is corrected, since the vast majority of cardiomyocytes are in a terminally differentiated state, the cells lack the ability to regenerate themselves, and once necrotic, it is difficult to regenerate, so the deterioration of cardiac function is difficult to reverse, and the mortality rate i...

AI Technical Summary

Problems solved by technology

And the heart continues to beat, which has a great impact on the precise control of the puncture injection location. When the puncture needle is completely fixed, it may cause secondary damage as the heart contracts and relaxes, and the injection location will also change.

The conventionally used puncture needle is a beveled puncture needle with a matching needle core inside. The needle body shows strong echoes under ultrasound. A thick puncture needle, such as an 18G puncture needle with an outer diameter of 1.2mm, is more conducive to penetrating superficial hard tissues, and Establish a stable channel in the tissue of the surrounding bony structure such as the chest wall, but the risk of injuring deep tissues, especially important tissues, is higher High, the direct damage to local myocardial tissue is also greater

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