Detection method for optical noninvasive measurement of blood glucose concentrations based on lips

A blood sugar concentration and detection method technology, applied in the field of optical detection, can solve problems such as low measurement accuracy, single detection method, and small measurement error

Active Publication Date: 2019-10-29
XI'AN PETROLEUM UNIVERSITY
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Problems solved by technology

[0005] In order to solve the defect that the existing non-invasive blood glucose meter detection method is single and the measurement accuracy is low due to various factors, the purpose of the present invention is to provide a detection method for non-invasive measurement of blood sugar concentration based on lip optics, which combines Raman spectrum and infrared spectrum Supplementary, with the characteristics of small measurement error

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  • Detection method for optical noninvasive measurement of blood glucose concentrations based on lips
  • Detection method for optical noninvasive measurement of blood glucose concentrations based on lips
  • Detection method for optical noninvasive measurement of blood glucose concentrations based on lips

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Embodiment Construction

[0028] The present invention will be further described in detail below in conjunction with specific embodiments and accompanying drawings.

[0029] A detection method based on lip optical non-invasive measurement of blood glucose concentration, comprising the following steps:

[0030] (1) making lip model 11; figure 1 It is a simple model of lip tissue structure. For simplicity, the model is divided into blood layer and skin layer;

[0031] (2) preparing test blood with different blood sugar concentrations;

[0032] (3) Reference figure 2 A coupler 3 and a temperature sensor 8 are set on the upper surface of the lower lip of the lip model 11, and a B coupler 4 is set on the lower surface of the lower lip; the infrared light source 1 and the laser light source 2 are output to the A coupler 3 by an optical fiber and then reach the sensor to be detected. The lip part of A coupler 3 reaches the Raman spectrometer 5, the reflected light of the B coupler 4 reaches the infrared s...

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Abstract

The invention discloses a detection method for optical noninvasive measurement of blood glucose concentrations based on lips. The detection method comprises the following steps that a human body lip model is manufactured; testing blood with different blood glucose concentrations is prepared; the blood glucose concentrations of the blood in the lip model are changed, the blood with the different blood glucose concentrations is used for testing, and thus spectrums of the blood with the different blood glucose concentrations are obtained; the obtained spectrums are subjected to spectral normalization processing, a calibrated spectrum matrix is spliced according to preset data, various spectral data are associated through a data fusion technology, a preset mathematic model is trained accordingto the spectral data, corresponding blood glucose values serving as input vectors and corresponding temperature values serving as input vectors, and thus a blood glucose measuring model is obtained;and then the blood with the different blood glucose concentrations is used for testing, thus Raman spectrums and infrared absorption spectrums of a set of to-be-tested blood glucose are obtained, a measuring matrix is constituted according to a preset method, and a prediction model is used for predicting the blood glucose values. The precision and reliability of measurement are improved; and the blood glucose of a human body can be noninvasively measured and can also be used for measuring other parameters.

Description

technical field [0001] The invention belongs to the technical field of optical detection, and in particular relates to a detection method for noninvasively measuring blood sugar concentration based on lip optics. Background technique [0002] Hundreds of millions of people around the world suffer from diabetes, which is a disease caused by endocrine and metabolic regulation disorders. Diabetes has become the second leading cause of death in the United States. The chronic complications of diabetes are not fully understood, and its effects on the circulatory system and blood vessels can damage tissues and organs of the body. To avoid hyperglycemia or hypoglycemia, adhere to a diet that includes carbohydrates and monosaturated fats with limited amounts of sucrose, combined with insulin medication. In order to accurately know the dosage of the drug, it is necessary to continuously detect the blood sugar level. The current method used is to frequently take a small amount of blo...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/1455
CPCA61B5/1455A61B5/14532
Inventor 李东明李春芳马成举杨阿平李雨蓓
Owner XI'AN PETROLEUM UNIVERSITY
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