A detection method for non-invasive measurement of blood glucose concentration based on lip optics

A blood sugar concentration and detection method technology, applied in the field of optical detection, can solve the problems of low measurement accuracy, small measurement error, single detection method, etc.

Active Publication Date: 2022-03-18
XI'AN PETROLEUM UNIVERSITY
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Problems solved by technology

[0005] In order to solve the defect that the existing non-invasive blood glucose meter detection method is single and the measurement accuracy is low due to various factors, the purpose of the present invention is to provide a detection method for non-invasive measurement of blood sugar concentration based on lip optics, which combines Raman spectrum and infrared spectrum Supplementary, with the characteristics of small measurement error

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  • A detection method for non-invasive measurement of blood glucose concentration based on lip optics
  • A detection method for non-invasive measurement of blood glucose concentration based on lip optics
  • A detection method for non-invasive measurement of blood glucose concentration based on lip optics

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Embodiment Construction

[0028] The present invention will be further described in detail below in conjunction with specific embodiments and accompanying drawings.

[0029] A detection method based on lip optical non-invasive measurement of blood glucose concentration, comprising the following steps:

[0030] Step (1) making lip model 11; figure 1 It is a simple model of lip tissue structure. For simplicity, the model is divided into blood layer and skin layer;

[0031] Step (2) preparing test blood with different blood glucose concentrations;

[0032] Step (3) refer to figure 2 A coupler 3 and a temperature sensor 8 are set on the upper surface of the lower lip of the lip model 11, and a B coupler 4 is set on the lower surface of the lower lip; the infrared light source 1 and the laser light source 2 are output to the A coupler 3 by an optical fiber and then reach the sensor to be detected. The lip part of A coupler 3 reaches the Raman spectrometer 5, the reflected light of the B coupler 4 reache...

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Abstract

A detection method for measuring blood sugar concentration based on lip optics noninvasively, comprising the following steps: making a human lip model; preparing test blood with different blood sugar concentrations; changing the blood sugar concentration of the blood in the lip model, and using blood tests with different blood sugar concentrations to obtain different blood sugar concentrations The spectrum of blood with high concentration; normalize the obtained spectrum, form a calibration spectrum matrix according to the preset data, use data fusion technology to correlate various spectral data, and use the spectral data and the corresponding blood sugar value and temperature value As the input vector, train the preset mathematical model to obtain the blood sugar measurement model; then use blood tests with different blood sugar concentrations to obtain a set of Raman spectra and infrared absorption spectra of the blood sugar to be measured, and form a measurement according to the preset method The matrix uses a prediction model to predict the blood sugar value; the invention improves the accuracy and reliability of the measurement; it can measure the blood sugar of the human body non-invasively, and can also be used for the measurement of other parameters.

Description

technical field [0001] The invention belongs to the technical field of optical detection, and in particular relates to a detection method for noninvasively measuring blood sugar concentration based on lip optics. Background technique [0002] Hundreds of millions of people around the world suffer from diabetes, which is a disease caused by endocrine and metabolic regulation disorders. Diabetes has become the second leading cause of death in the United States. The chronic complications of diabetes are not fully understood, and its effects on the circulatory system and blood vessels can damage tissues and organs of the body. To avoid hyperglycemia or hypoglycemia, adhere to a diet that includes carbohydrates and monosaturated fats with limited amounts of sucrose, combined with insulin medication. In order to accurately know the dosage of the drug, it is necessary to continuously detect the blood sugar level. The current method used is to frequently take a small amount of blo...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/1455
CPCA61B5/1455A61B5/14532
Inventor 李东明李春芳马成举杨阿平李雨蓓
Owner XI'AN PETROLEUM UNIVERSITY
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