A human brain gene spatiotemporal expression pattern online analysis system and method thereof

Abstract

The invention discloses an online analysis system and method for gene human brain spatiotemporal expression patterns. The reference database platform includes human brain gene spatiotemporal expression norms, thousand genome database, Ensembl database and dbSNP database; human brain gene spatiotemporal expression norms Based on the constructed spatio-temporal framework of each brain region and each developmental stage, form the matrix expression pattern of genes or gene modules between each brain region and each developmental stage, as well as the enrichment matrix expression pattern between gene modules and cell types; There is a data analysis module on the server side; a gene set data input module and a graphic visualization module are set on the client side, the server side analyzes the spatio-temporal pattern of the input gene set data, and analyzes the genes through the graphic visualization module The results are presented graphically. The invention generates user-friendly and easy-to-understand visualization results on the client side, helps clarify the complex spatio-temporal expression patterns of genes, and reflects the relationship between the analyzed genes.

Description

technical field [0001] The invention relates to the technical field of human brain modeling, and in particular to an online analysis system and method for human brain gene spatiotemporal expression patterns. Background technique [0002] The development of the human brain occurs over a long period of time, with extremely complex and precise regulation. From embryonic stage to adulthood and various stages of aging, the human brain undergoes long-term development, refinement and maturation, undergoing molecular, connection and structural changes. Provide insights into susceptibility to certain brain disorders such as neurodegenerative and psychiatric disorders by studying gene expression patterns in regions of normal brain function, developmental stages, and different neural cell types. [0003] At present, there are some human brain gene expression databases, but not all databases or tools support the analysis of different types of genetic results. For example, Allen Brain A...

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Problems solved by technology

[0004] In order to solve the problem that existing databases or tools are difficult to analyze different types of genetic results, and at the same time it is impossible to analyze the co-expression relationship between genes, the present invention provides an online analysis system for human brain gene spatiotemporal expression patterns and its This method provides an important research basis for obtaining the temporal and spatial expression patterns of disease susceptibility genes in the brain

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