Tumor necrosis targeting compositions and methods
A technology that targets tumor cells and is used in drug combinations, anti-tumor drugs, pharmaceutical formulations, etc., and can solve problems such as no known therapeutic interventions
Pending Publication Date: 2019-11-08
CANCER THERAPEUTICS LAB INC
View PDF2 Cites 0 Cited by
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
However, to date there are no known established therapeutic interventions utilizing such target molecules
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View moreImage
Smart Image Click on the blue labels to locate them in the text.
Smart ImageViewing Examples
Examples
Experimental program
Comparison scheme
Effect test
example
[0043] sequencing : NANT-1 antibody sequence information was derived from mRNA of NANT-1 producing hybridoma cells (murine) following standard protocols well known in the art. murine IgG 1 The sequences of the isotypes are known, and only the variable heavy and light chain information is provided below, with the corresponding CDR regions underlined:
[0044] Heavy Chain Variable Region Sequence (SEQ ID NO:2):
[0045] QESGPQLVRPGASVKISCKAS GYSFTSY WMHWVKQRPGQGLEWIGMI DPSDSE TRLNQKFKDKATLTVDKSSSTAYMQLNSPTSEDSAVYYCAR DGGYYAWFAY WGQGTLVTVSA
[0046] Light chain variable region sequence (SEQ ID NO:3):
[0047] DIVLTQTPKSMSMSVCJERVTLTC KASENVVTYVS WYVQKPEQSPKLLIY GASNRYT GVPDRFTGSGSATDFLTISSVQAEDLADYHC GQGYSYPYT FGGGTKLEIKRA
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More PUM
Login to View More Abstract
Compositions and methods employ an anti-nucleolin antibody or fragment thereof to specifically target necrotic tumor cells. Thus, and in preferred aspects, compositions and methods may be used to target the tumor microenvironment and cancer cells within such milieu. Also included are methods of targeting necrotic cells with binding agent that specifically binds nucleolin.
Description
[0001] Cross References to Related Applications [0002] This application claims the benefit of priority to U.S. Provisional Patent Application Serial No. US 62 / 473,552, filed March 20, 2017, the contents of which are incorporated herein by reference. technical field [0003] The field of the invention is compositions and methods for targeting necrotic cells, and especially necrotic cells in solid tumors. Background technique [0004] The Background Description includes information useful in understanding the present invention. It is not an admission that any information provided herein is prior art or relevant to the presently claimed invention, or that any publication specifically or implicitly referenced is prior art. [0005] All publications and patent applications are herein incorporated by reference to the same extent as if each individual such publication or patent application was specifically and individually indicated to be incorporated by reference. Where a defi...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More Application Information
Patent Timeline
Login to View More IPC IPC(8): A61K39/395C07K16/18C07K16/28C07K16/30C12N5/071
CPCC07K16/18A61K2039/505A61P35/00A61K45/06A61K47/6801A61K51/1027C07K16/28
Inventor A·爱泼斯坦
Owner CANCER THERAPEUTICS LAB INC