S100 protein family-based acute pancreatitis severity prediction model and detection method thereof

Abstract

The invention discloses an S100 family-based acute pancreatitis severity prediction model and detection method thereof, and belongs to the technical field of acute pancreatitis detection. The acute pancreatitis severity prediction model is established by utilizing S100A6, S100A8, S100S9, S100A11, S100A12 and S100P in the S100 protein family; and for severe acute pancreatitis, the prediction modelhas a diagnosis sensitivity of 92.30%, a specificity of 84.70%, a false positive rate of 15.30% and a false negative rate of 7.70%. Compared with the present clinically used scale detection and imaging diagnosis, the prediction model has reduced subjectivity, is more correct and has a quantitative detection effect.

Description

technical field [0001] The invention relates to a model for predicting the severity of acute pancreatitis based on the S100 protein family and a detection method thereof, belonging to the technical field of detection of acute pancreatitis. Background technique [0002] Acute pancreatitis is the most common aseptic inflammation of the pancreas, the main pathological manifestations are pancreatic acinar cell damage and necrosis and inflammatory cascade reaction. According to international clinical data, its incidence rate is as high as 13-45 / 100,000 people, and it shows an increasing trend year by year. In the United States, more than 200,000 patients with acute pancreatitis need to be hospitalized every year, and the direct treatment cost is as high as 2 billion U.S. dollars per year. According to the severity of acute pancreatitis, the latest Atlanta classification in 2012 divided acute pancreatitis into mild acute pancreatitis (MAP), moderately severe acute pancreatitis (M...

AI Technical Summary

Problems solved by technology

However, the prediction of the severity of the disease by these evaluation methods mainly relies on the accumulation of clinicians' years of clinical practice experience, which is highly subjective and difficult to achieve early warning of severe acute pancreatitis

In addition, some studies have proposed to use the interleukin family (IL-6, IL-8, etc.), tumor necrosis factor (TNF) levels, etc. , and the sensitivity and specificity of the early diagnosis of severe acute pancreatitis are not up to the clinical requirements, and there are limitations such as complex detection and high cost

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