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Preparation of two radix-aconiti-carmichaeli alkaloid combined drugs and application of drugs in treatment of liver cancer

A technology of total alkaloids and liver cancer, which is applied in the field of anti-tumor drugs to achieve the effect of ensuring the tumor-suppressing effect, promoting proliferation, and inhibiting the growth of tumors

Active Publication Date: 2019-11-15
LANZHOU UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, cancer patients are often multiple immunodeficiencies, and targeting a single immunodeficiency is not sufficient to induce strong anticancer immunity

Method used

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  • Preparation of two radix-aconiti-carmichaeli alkaloid combined drugs and application of drugs in treatment of liver cancer
  • Preparation of two radix-aconiti-carmichaeli alkaloid combined drugs and application of drugs in treatment of liver cancer
  • Preparation of two radix-aconiti-carmichaeli alkaloid combined drugs and application of drugs in treatment of liver cancer

Examples

Experimental program
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Effect test

Embodiment 1

[0042] 1. Experimental materials:

[0043] The total alkaloids of Fuzi were prepared by Lanzhou University, and the preparation method is detailed above;

[0044] Aconitine was purchased from Beijing Yipreis Technology Co., Ltd., product number MUST-17022206;

[0045] Taurine was purchased from SIGMA-ALDRICH company, product number T0625-25G;

[0046] PolyIC was purchased from Kaiping Chenniu Biochemical Pharmaceutical Co., Ltd., product number 160901;

[0047] 5-FU was purchased from Gansu Provincial People's Hospital, product number FA170301.

[0048] ANTI-MOUSE CD3-FITC was purchased from Thermo Fisher scientific, product number 4275976;

[0049] ANTI-MOUSE CD69-PE was purchased from eBioscience, product number 60A353811712;

[0050] MOUSE IFN-αELISA KIT was purchased from Shanghai Ji Ning Industrial Co., Ltd., product number A05115;

[0051] MTT was purchased from Solarbio, product number M8180;

[0052] PBS was prepared by Lanzhou University with conventional prepar...

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Abstract

The invention discloses two radix-aconiti-carmichaeli alkaloid combined drugs for treatment of liver cancer, and provides preparation methods of the drugs and the application of the drugs in treatmentof the liver cancer. The combined drugs include radix-aconiti-carmichaeli total alkaloids or aconitine, an antioxidant (taurine) and a TLR3 ligand (PolyIC). The drugs have the advantages that the provided two radix-aconiti-carmichaeli alkaloid combined drugs effectively inhibit the growth of the cancer and promote the proliferation of lymphocytes, especially T lymphocytes , the PolyIC and the taurine promote the release of IFN-alpha, the combination of the PolyIC, the taurine and the radix-aconiti-carmichaeli alkaloids helps maintain the release of the IFN-alpha, and thus the anti-tumor effect is ensured.

Description

technical field [0001] The invention relates to the field of antitumor drugs, in particular to a preparation method and application of total aconite alkaloids or aconitine, combined with taurine and PolyIC which have been applied in clinical practice, to construct a drug for treating liver cancer. Background technique [0002] In recent years, there have been more than 780,000 new cases of hepatocellular carcinoma (HCC), and more than 740,000 deaths, half of which came from China. Sorafenib is currently the only drug approved by the US FDA for advanced HCC. Patients with liver cancer are more difficult to tolerate traditional chemotherapy drugs than other cancers. Therefore, local targeting and overall regulation are more feasible for the treatment of liver cancer. [0003] Cancer poison belongs to yin evil, and aconite is the first essential product for warming yang. The traditional Chinese medicine Aconiti Lateralis Radix Praeparata is a processed product of the root of A...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/439A61K36/714A61K31/185A61K31/713A61P35/00
CPCA61K31/439A61K36/714A61K31/185A61K31/713A61P35/00A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 李青杨凤鸽李雯张小芸王颢令亚琴
Owner LANZHOU UNIVERSITY
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