Application of natural compound Egenine in preparing medicament for resisting renal fibrosis

Abstract

The invention discloses an application of a natural compound Egenine in preparing a medicament for resisting renal fibrosis. Most chronic kidney diseases can lead to renal fibrosis, such as primary glomerular disease, chronic pyelonephritis, renal damage caused by systemic diseases (such as lupus nephritis and diabetic nephropathy, etc.), and nephropathy caused by genetic factors (such as Alport syndrome), etc. Renal fibrosis is a multi-factor-driven pathological process involving inflammation, oxidative stress, effects and signaling cascades of various cytokines, apoptosis, fibroblast proliferation and activation, and transformation of epithelial cells into fibroblasts, etc. Research of the invention shows that the natural compound Egenine has remarkable anti-renal fibrosis activity and has an application prospect of being developed into the medicament for resisting renal fibrosis.

Description

technical field [0001] The invention belongs to the field of medicine and relates to the new application of known compounds, in particular to the application of a natural compound Egenine for preparing anti-renal fibrosis drugs. Background technique [0002] Chronic kidney disease has become another disease that seriously threatens human health after cardiovascular and cerebrovascular diseases, tumors, and diabetes. Most patients with chronic kidney disease can get a correct diagnosis before developing end-stage renal disease. Unfortunately, there is currently no effective treatment to completely prevent the progressive decline in renal function caused by chronic kidney disease. [0003] Most chronic kidney diseases can lead to renal fibrosis, such as primary glomerular disease, chronic pyelonephritis, kidney damage caused by systemic diseases (such as lupus nephritis and diabetic nephropathy, etc.), and renal diseases caused by genetic factors ( Such as Alport syndrome) an...

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Problems solved by technology

Facts have also proved that although the use of angiotensin-converting enzyme inhibitors alone can slow down the progress of renal failure, it has no significant effect on the reversal of the disease; a single cytokine antibody cannot completely block or reverse the occurrence of fibrosis, and sometimes Adverse reactions occur

[0005] Egenine is a natural source of alkaloid compound, CAS accession number 6883-44-9, its activity research is very little, no prior art has disclosed its anti-renal fibrosis activity

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