Application of natural compound Egenine in preparing medicament for resisting renal fibrosis

A natural compound, the technology of renal fibrosis, applied in the field of medicine, can solve the problems of adverse reactions, few activity studies, and the inability of a single cytokine antibody to completely block or reverse fibrosis

Inactive Publication Date: 2019-12-13
CHINA PHARM UNIV
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Facts have also proved that although the use of angiotensin-converting enzyme inhibitors alone can slow down the progress of renal failure, it has no significant effect on the reversal of the disease; a single cytokine antibody cannot completely block or re

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of natural compound Egenine in preparing medicament for resisting renal fibrosis
  • Application of natural compound Egenine in preparing medicament for resisting renal fibrosis
  • Application of natural compound Egenine in preparing medicament for resisting renal fibrosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0020] The following describes the substantive content of the present invention in detail in conjunction with the drawings and embodiments, but does not limit the protection scope of the present invention.

[0021] 1. Experimental materials

[0022] 1. Experimental materials

[0023] The purity of Egenine is not less than 95%; SPF grade ICR mice were purchased from Qinglongshan Animal Breeding Farm, Jiangning District, Nanjing (Jiangsu Province Experimental Animal Quality Certificate No. 201926974).

[0024] 2. Main experimental reagents

[0025] Paraformaldehyde (Tianjin Guangfu Fine Chemical Research Institute), xylene (Sinopharm Chemical Reagent Co., Ltd.), H&E dye solution (Beijing Suolaibao Biology), masson dye solution set (Beijing Suolaibao Biology), neutral gum (Sinopharm Chemical Reagent Co., Ltd.), Fibronectin antibody (Abcam, ab45688), CollagenⅠ antibody (Abcam, ab34710), CollagenⅢ antibody (Proteintech, 22734-1-AP), α-SMA antibody (Abcam, ab124964), glycine and T...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses an application of a natural compound Egenine in preparing a medicament for resisting renal fibrosis. Most chronic kidney diseases can lead to renal fibrosis, such as primary glomerular disease, chronic pyelonephritis, renal damage caused by systemic diseases (such as lupus nephritis and diabetic nephropathy, etc.), and nephropathy caused by genetic factors (such as Alport syndrome), etc. Renal fibrosis is a multi-factor-driven pathological process involving inflammation, oxidative stress, effects and signaling cascades of various cytokines, apoptosis, fibroblast proliferation and activation, and transformation of epithelial cells into fibroblasts, etc. Research of the invention shows that the natural compound Egenine has remarkable anti-renal fibrosis activity and has an application prospect of being developed into the medicament for resisting renal fibrosis.

Description

technical field [0001] The invention belongs to the field of medicine and relates to the new application of known compounds, in particular to the application of a natural compound Egenine for preparing anti-renal fibrosis drugs. Background technique [0002] Chronic kidney disease has become another disease that seriously threatens human health after cardiovascular and cerebrovascular diseases, tumors, and diabetes. Most patients with chronic kidney disease can get a correct diagnosis before developing end-stage renal disease. Unfortunately, there is currently no effective treatment to completely prevent the progressive decline in renal function caused by chronic kidney disease. [0003] Most chronic kidney diseases can lead to renal fibrosis, such as primary glomerular disease, chronic pyelonephritis, kidney damage caused by systemic diseases (such as lupus nephritis and diabetic nephropathy, etc.), and renal diseases caused by genetic factors ( Such as Alport syndrome) an...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/4741A61P13/12
CPCA61K31/4741A61P13/12
Inventor 周伟张之昊何俊秋张春磊殷爱玲
Owner CHINA PHARM UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap