Composition containing morpholinyl propoxy quinazoline derivatives

A technology of morpholinopropoxyquinazoline and composition, which is applied to medical preparations containing active ingredients, medical raw materials derived from ferns/filamentous plants, plant raw materials, etc., and can solve the problems that need to be further improved. question

Inactive Publication Date: 2019-12-13
黄泳华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Plant extracts are rich in a variety of ingredients with antibacterial activity. For example, Yang Ruoying et al. reported (Journal of Tropical Biology, 2019, 10(03): 226-230.) The extracts of plants such as horn wind, six ear bells, rattan notoginseng, Guanzhong, golden thread grass, unipedal wind, eight hundred centimeters, and piercing stone have the effect on tobacco Ralstonia solanacearum at 100mg / L and / or 500mg / L Certain antibacterial activity, but the inventors found that the antibacterial activity of the above-mentioned plant extracts to other common pathogenic bacteria needs to be further improved

Method used

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  • Composition containing morpholinyl propoxy quinazoline derivatives
  • Composition containing morpholinyl propoxy quinazoline derivatives
  • Composition containing morpholinyl propoxy quinazoline derivatives

Examples

Experimental program
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Effect test

preparation example 1

[0020] The preparation of preparation example 1 plant extract

[0021] Ultrasonic extraction method is used to dry the shade-dried plant material at 40°C, crush it, pass through a 40-mesh sieve, and put it into a ziplock bag. Before the test, 50 g of plant dry powder was weighed, and different organic solvents were added for ultrasonic extraction (as shown in Table 1), and the extraction was repeated 3 times for 60 min each time. Concentrate after filtration and store in a refrigerator at 4°C until use.

[0022] Table 1 Organic solution of ultrasonic extraction of different plant extracts

[0023] plant material Extract number Organic solvents broken bone PE1 Dichloromethane white diamond PE2 Isopropanol mountain star anise PE3 Chloroform wind PE4 ethyl acetate Six ear bells PE5 Chloroform Fuji Sanchi PE6 Isopropanol Guan Zhong PE7 Chloroform Bone style PE8 Isopropanol Guangchamasma PE...

Embodiment 1

[0101] Embodiment 1 The preparation of the oral solid formulation of the composition containing the mixture of morpholino propoxyquinazoline derivatives

[0102] Prescription (1500 unit dose)

[0103]

[0104]

[0105] Note;

[0106] a NA stands for no added plant extracts

[0107] Preparation

[0108] Take the mixture X-Y-PEZ and auxiliary materials in the prescribed amount, and pass through a 100-mesh sieve. Take the mixture X-Y-PEZ, lactose, microcrystalline cellulose, crospovidone and starch and mix thoroughly; take the prescribed amount of hypromellose, and prepare a solution with a concentration of 10% based on hypromellose, Use lactic acid to adjust the pH to 3.0-4.0, add it to the above-mentioned mixture to make a soft material, granulate with a 16-mesh sieve, and dry at 80°C for 3-4 hours. Use a 16-mesh sieve to sieve the granules, add the prescribed amount of micropowder silica gel and magnesium stearate, mix well, fill the capsules, and obtain capsules...

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PUM

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Abstract

The invention provides a composition containing a mixture of a first morpholinyl propoxy quinazoline derivative and a second morpholinyl propoxy quinazoline derivative which are mutually different. The definition of morpholinyl propoxy quinazoline is as shown in the descriptions. The mixture of the morpholinyl propoxy quinazoline derivatives disclosed by the invention, and various plant extracts of jasminum lanceolarium roots, stems and leaves, kadsura roots, Illicium simonsii, alpinia sichuanensis and the like to generate synergistic antibacterial action.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a composition of morpholinopropoxyquinazoline derivatives and an application thereof. Background technique [0002] Nosocomial infection is an important issue affecting the quality of hospital care. With the continuous development and progress of modern medical technology, antibacterial drugs are widely used, and the drug-resistant strains of clinical pathogens are increasing. Therefore, improving the antibacterial activity of existing drugs will help to improve the therapeutic effect of patients with bacterial infections. [0003] CN108939081A discloses an antibacterial pharmaceutical composition containing metformin and morpholino propoxy quinazoline derivatives shown in formula I, and discloses the antibacterial activity of said morpholino propoxy quinazoline derivatives when administered alone . [0004] [0005] Plant extracts are rich in a variety of ingr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/5377A61K36/63A61K36/79A61K36/57A61K36/746A61K36/9062A61K36/185A61K36/12A61K36/888A61K36/70A61K36/64A61K36/53A61K36/704A61K36/47A61K36/60A61K36/28A61K36/41A61K36/282A61K36/74A61K36/13A61P31/04
CPCA61K31/5377A61K36/12A61K36/13A61K36/185A61K36/28A61K36/282A61K36/41A61K36/47A61K36/53A61K36/57A61K36/60A61K36/63A61K36/64A61K36/70A61K36/704A61K36/74A61K36/746A61K36/79A61K36/888A61K36/9062A61P31/04A61K2300/00Y02A50/30
Inventor 向飞张斌
Owner 黄泳华
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