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Polypeptide for preventing and treating eimeria tenella and pharmaceutical composition containing polypeptide

A composition and drug technology, applied in the field of polypeptides and pharmaceutical compositions containing them, can solve the problems of anti-Eimeria tenella antimicrobial peptides

Active Publication Date: 2019-12-24
台山市润沣农业技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] So far there is no report of antimicrobial peptides with anti-Eimeria tenella

Method used

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  • Polypeptide for preventing and treating eimeria tenella and pharmaceutical composition containing polypeptide
  • Polypeptide for preventing and treating eimeria tenella and pharmaceutical composition containing polypeptide
  • Polypeptide for preventing and treating eimeria tenella and pharmaceutical composition containing polypeptide

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] The amino acid sequence characteristics of the natural antibacterial peptide library were statistically analyzed, and the parameters of the peptide chain with good antibacterial activity were screened. The amino acid sequence obtained by screening is shown in SEQ ID NO: 1. The sequence has 3 positively charged amino acids and a molecular weight of 2172.51. The artificial polypeptide of the above polypeptide sequence (SEQ ID NO: 1) is chemically synthesized, and the purified purity is as high as 97%.

Embodiment 2

[0042] Preparation of BAP13 storage solution: 10 mg was dissolved in 1 ml PBS (pH 7.2), the concentration of the storage solution was 10 mg / ml, and stored at -20°C.

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Abstract

The invention relates to polypeptides for treating chicken coccidiosis, in particular to a polypeptide for preventing and treating eimeria tenella and a pharmaceutical composition containing the polypeptide. The polypeptide has no obvious toxic effect on a host and has no pollution to the environment. Tests prove that the MIC50 of the polypeptide to eimeria tenella is 63.15 [mu]g / ml, and the polypeptide has a good eimeria tenella resisting effect.

Description

technical field [0001] The invention relates to a polypeptide for treating chicken coccidiosis, in particular to a polypeptide for preventing and treating Eimeria tenella and a pharmaceutical composition containing the polypeptide. Background technique [0002] Chicken coccidiosis is a parasitic protozoan disease that seriously endangers the development of chicken industry. The disease is distributed worldwide, the incidence rate is usually 50-70%, and the mortality rate can be as high as 60-80%. The annual economic loss caused by this is as high as more than 2.5 billion pounds. The pathogen is Eimeria apicomplexa Coccidia (Eimeria spp), the most harmful of which is Eimeria tenella (E. tenella). According to incomplete statistics, the economic loss caused by chicken coccidiosis in my country is not less than 2.5 billion yuan every year. Chemical drug treatment is one of the important measures to control coccidiosis in chickens, but at present chicken coccidiosis has extens...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K7/08C12N15/11A61K38/10A61K45/06A61P33/02
CPCA61K38/00A61K45/06A61P33/02C07K7/08
Inventor 胡俊菁廖申权孙铭飞戚南山吕敏娜吴彩艳李娟林栩慧蔡海明肖文婉张健騑谢明权
Owner 台山市润沣农业技术有限公司
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