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A kind of pheromone composition spray preparation and its preparation method and application

A technology of composition and pheromone, which is applied in the direction of drug combination, aerosol delivery, pharmaceutical formulation, etc., and can solve problems affecting food safety, imperfect combination, ecological environment impact, etc.

Active Publication Date: 2021-07-30
宁波第二激素厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, if quinoline is used improperly, it will affect the health of users and also have a certain impact on the ecological environment.
In addition, some studies have found that heterocyclic aromatic compounds may have a certain growth-promoting effect, which will interfere with the growth and development of female animals, which is not conducive to embryonic development, which will also affect food safety. Substances or drugs with growth-promoting effects, in Many countries and regions are strictly prohibited for food animals
Therefore, the product portfolio is not perfect enough, and there are also great security risks
[0012] Therefore, the existing methods cannot meet the needs of the current sow batch production technology in terms of effectiveness and safety, that is, a higher estrus rate can be assigned

Method used

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  • A kind of pheromone composition spray preparation and its preparation method and application
  • A kind of pheromone composition spray preparation and its preparation method and application
  • A kind of pheromone composition spray preparation and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] According to the formulation of the composition solution containing pheromone androstenone and Epimedium extract (Icariin, Simga-Aldrich, ≥94.0%, HPLC) listed in Table 4. Prepare 1000ml D composition solution with reference to the solution preparation method of Examples 1 and 2. Before use, the solution is dispensed into spray devices, 100ml per bottle.

[0052] Table 4 Formula of pheromone composition solution

[0053] components percentage,% g androstenone 0.002 0.002 Epimedium Extract 0.002 0.002 Dimethyl sulfoxide 1.0 1.0 Tween 80 0.05 0.05 preservative 0.3 0.3 purified water 98.646 98.646 total 100.000 100.000

Embodiment 2

[0055] According to the formulation of the composition solution containing pheromone androstenol and Epimedium extract listed in Table 5. Referring to the solution preparation method of Examples 1 and 2, 1000ml E composition solution was prepared. Before use, the solution is dispensed into spray devices, 100ml per bottle.

[0056] Table 5 Formula of pheromone composition solution

[0057] components percentage,% g androstenol 0.002 0.002 Epimedium Extract 0.002 0.002 Dimethyl sulfoxide 1.0 1.0 Tween 80 0.05 0.05 preservative 0.3 0.3 purified water 98.646 98.646 total 100.000 100.000

Embodiment 3

[0059] According to the formula of the composition solution containing pheromone androstenone, androstenol and epimedium extract listed in table 6. Accurately weigh androstenone, androstenol, and epimedium extract according to the formula amount in Table 6, join in the dimethyl sulfoxide of prescription amount, sonication assists 20 minutes; After it dissolves completely, Add it into purified water, start stirring, add the prescribed amount of Tween-80 while stirring, then continue to stir, then add preservatives, then add purified water to the prescribed amount, then continue stirring for 2 hours, after filtering with a 0.45 micron membrane filter That is, the solution of composition F is obtained. Before use, the solution is dispensed into spray devices, 100ml per bottle.

[0060] Table 6 Formula of pheromone composition solution

[0061] components percentage,% g androstenone 0.002 0.002 androstenol 0.002 0.002 Epimedium Extract 0.002 0.0...

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Abstract

The invention relates to a pheromone composition, in particular to a pheromone composition spray preparation and a preparation method and application thereof. A pheromone composition spray preparation, the spray preparation comprising: androstenone and / or androstenol 0.001-0.02%; Epimedium extract 0.001-0.02%; dimethyl sulfoxide 0.2% ‑20%; Tween‑800.01‑0.5%; preservative 0.1‑1.0%; purified water 80.0‑99.0%. The spray formulation is safer and more reliable, and reliably improves the reproductive performance of sows (ie, higher estrus rate), improves sow utilization, and improves sow fertility.

Description

technical field [0001] The invention relates to a pheromone composition, in particular to a pheromone composition spray preparation and a preparation method and application thereof. Background technique [0002] The word "pheromone (Pheromone)" was proposed by researchers in the 1950s. It is composed of two ancient Greek words Pherein (transmission) and hormone (excitement). It is considered to be a class of chemical substances that can elicit sexual responses in animals of the same sex, so it is also called pheromones, and plays an important role in some behavioral and sexual interactions, as well as in the control of reproduction. Pheromone is a chemical substance secreted by the exocrine glands of insects outside the body. It acts on other individuals of the same species through personal contact or air transmission, causing specific behavior or physiological responses. Insect sex pheromones can mainly be used in the prediction and forecasting of pests, directly trapping ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/565A61K36/296A61K9/12A61K47/26A61K47/20A61P15/08
CPCA61K9/12A61K31/565A61K36/296A61K47/20A61K47/26A61P15/08A61K2300/00
Inventor 岑桂英钱星宇李伟吴春山原敏何玲飞
Owner 宁波第二激素厂
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