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Composition and preparation method and preparation thereof

A composition and mixture technology, which is applied in drug combination, drug delivery, pharmaceutical formulation, etc., can solve the problems of short shelf life, inconvenient use, short half-life of nicotinamide mononucleotide, etc., and achieve the effect of improving stability

Inactive Publication Date: 2020-02-21
明特奇点医疗科技(北京)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, due to the poor chemical stability of nicotinamide mononucleotide, the shelf life of products made of nicotinamide mononucleotide is relatively short
In addition, due to the short half-life of nicotinamide mononucleotide, it needs to be used multiple times a day to achieve the corresponding therapeutic and health effects, which is inconvenient to use.

Method used

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  • Composition and preparation method and preparation thereof
  • Composition and preparation method and preparation thereof
  • Composition and preparation method and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031]

[0032] Preparation of drug-loaded resin particles: add the prescription amount of polyclinic to a container filled with 100ml deionized water, add nicotinamide mononucleotide under stirring, and continue stirring at 200rpm for 10h, and then leave it to stand still after the adsorption equilibrium. Use a titanium rod to filter, discard the filtrate to collect the filter cake, dry in a blast drying oven at 50°C, and pass through a 60-mesh sieve to obtain drug-loaded resin particles.

Embodiment 2

[0034]

[0035] Preparation of drug-loaded resin particles: add the prescription amount of polyclinic potassium to a container filled with 100ml of deionized water, add nicotinamide mononucleotide under stirring, continue stirring at 500rpm for 4h, and then stand still after the adsorption equilibrium 、Use a titanium rod to filter, discard the filtrate to collect the filter cake, dry in a blast drying box at 50°C, and pass through a 60-mesh sieve to obtain drug-loaded resin particles.

Embodiment 3

[0037]

[0038] Preparation of drug-loaded resin particles: add the prescription amount of sodium polystyrene sulfonate into a container filled with 100ml deionized water, add nicotinamide mononucleotide under stirring, continue stirring at 500rpm for 4h, and leave it to stand after adsorption equilibrium , Use a titanium rod to filter, discard the filtrate to collect the filter cake, dry in a blast drying box at 50°C, and pass through a 60-mesh sieve to obtain drug-loaded resin particles.

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Abstract

The invention discloses a composition as well as a preparation method and a preparation thereof. The composition of the present invention includes nicotinamide mononucleotide, an ion exchange resin, acoating material, and a plasticizer. The preparation method comprises the following steps: preparing the drug-loaded resin particles, and coating the drug-loaded resin particles. The coated drug-loaded resin particles are mixed with other auxiliary materials to prepare corresponding dosage forms, such as oral suspension, tablets, capsules, granules, cream, ointment, facial masks and the like. Thecomposition is simple in production process, easy to amplify and produce, capable of effectively improving the stability of nicotinamide mononucleotide, accurate in dosage, lasting in effect and stable in curative effect.

Description

Technical field [0001] The invention belongs to the technical field of medicine, and particularly relates to a composition of nicotinamide mononucleotide and ion exchange resin and a preparation method thereof. Background technique [0002] Nicotinamide mononucleotide (NMN) is an intermediate in the salvage synthesis pathway of nicotinamide adenine dinucleotide (NAD+) in mammals. Recent studies have found that artificial supplementation of NMN can repair brain damage, improve pancreatic islet function, protect the heart from ischemia-reperfusion injury, repair brain mitochondrial respiratory defects, and is effective for elderly degenerative diseases, retinal degenerative diseases, type 2 diabetes, cerebral hemorrhage, etc. Both have a certain therapeutic effect. [0003] In the prior art, due to the poor chemical stability of nicotinamide mononucleotide, the shelf life of products made from nicotinamide mononucleotide is short. In addition, due to the short half-life of nicotina...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/706A61K47/30A61K9/50A61P25/28A61P27/02A61P9/10A61P3/10A61P7/04A61P25/00
CPCA61K31/706A61K47/30A61K9/5026A61K9/5047A61P25/28A61P27/02A61P9/10A61P3/10A61P7/04A61P25/00
Inventor 侯佳忆
Owner 明特奇点医疗科技(北京)有限公司
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