A sampling head, sampling system, mass spectrometry imaging device and sampling method

A sampling system and sampling head technology, used in mass spectrometers, measuring devices, instruments, etc., can solve the problems of cell folding, increase of interfering compounds, loss of key compound information, etc., to improve sampling quality, increase sampling droplet concentration, reduce The effect of information loss

Active Publication Date: 2021-05-18
SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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Problems solved by technology

At present, the metabolic molecular characteristics of tumor tissue are obtained by mass spectrometry analysis of isolated tissue surface material samples, while the freezing and cutting of isolated tissue will cause cell folding and fragmentation, resulting in the loss of some key compound information and the interference of intracellular overflow compound increase

Method used

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  • A sampling head, sampling system, mass spectrometry imaging device and sampling method
  • A sampling head, sampling system, mass spectrometry imaging device and sampling method
  • A sampling head, sampling system, mass spectrometry imaging device and sampling method

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Embodiment Construction

[0040] Explanation of terms:

[0041] Mass Spectrometry: A method in which moving ions are separated according to their mass-to-charge ratios by electric and magnetic fields and then detected. Substances can be identified by their mass-to-charge ratios.

[0042] Mass spectrometry imaging technology: Mass spectrometry imaging is an imaging method based on mass spectrometry technology. This method directly scans biological samples for imaging through mass spectrometry, and can simultaneously analyze the spatial distribution characteristics of hundreds of molecules on the same tissue slice or tissue chip. In simple terms, mass spectrometry imaging technology is a method of imaging with the help of mass spectrometry, coupled with the control of specialized mass spectrometry imaging software, using a mass spectrometer that analyzes the standard molecular weight of biomolecules by determining the mass-to-charge ratio.

[0043] Extraction: Extracting a substance using an extractant. ...

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Abstract

The invention discloses a sampling head, a sampling system, a mass spectrometer imaging device and a sampling method. The sampling head includes: a sampling body, one of two opposite sides of the sampling body is provided with a tenon, and the other side is opposite to a A mortise with a size matching the mortise is provided; a sampling cavity, the sampling cavity is arranged on the first end face of the sampling body, and the sampling cavity forms a sampling area with the sampled surface; it is used for injecting and extracting The first flow channel for reagents; the second flow channel for injecting air and the third flow channel for exporting sample droplets. Since the sampling head in the present invention is directly in contact with the surface to be sampled, sampling can be realized without being separated from the body, and the method of liquid droplet extraction will not cause trauma to the surface to be sampled, and the sampling cavity is close to the surface to be sampled, which improves the quality of the sampling liquid. Drop concentration, reducing the possibility of loss of key compound information, thereby improving sampling quality.

Description

technical field [0001] The invention relates to the technical field of lipidomics, more specifically, to a sampling head, a sampling system, a mass spectrometer imaging device and a sampling method. Background technique [0002] With the development of mass spectrometry, lipidomics has shown broad application prospects in the identification of tumor biomarkers, disease diagnosis, discovery of drug targets and lead compounds, and research on the mechanism of drug action. At present, the metabolic molecular characteristics of tumor tissue are obtained by mass spectrometry analysis of isolated tissue surface material samples, while the freezing and cutting of isolated tissue will cause cell folding and fragmentation, resulting in the loss of some key compound information and the interference of intracellular overflow compound increased. [0003] Therefore, how to improve the sampling quality is an urgent problem to be solved by those skilled in the art. Contents of the inven...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/62H01J49/26
CPCG01N27/62H01J49/26
Inventor 罗茜邓卡潘挺睿
Owner SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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