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Pharmaceutical composition for preventing and/or treating diarrhea-type irritable bowel syndrome and its preparation method and application

A technology of irritable bowel syndrome and composition, which is applied in the direction of drug combination, drug delivery, and pharmaceutical formulation, which can solve the problems of easy recurrence and achieve the effects of improving the quality of life, reducing the level of 5-HT, and reducing the recurrence rate

Active Publication Date: 2021-11-12
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] For IBS, Western medicine currently has no satisfactory treatment methods. It mainly focuses on symptomatic treatment. Gastrointestinal motility drugs, calcium channel antagonists and drugs that regulate autonomic nerve function are often used. Relapse is easy after drug withdrawal

Method used

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  • Pharmaceutical composition for preventing and/or treating diarrhea-type irritable bowel syndrome and its preparation method and application
  • Pharmaceutical composition for preventing and/or treating diarrhea-type irritable bowel syndrome and its preparation method and application
  • Pharmaceutical composition for preventing and/or treating diarrhea-type irritable bowel syndrome and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Take by weighing 20g of sunburned astragalus, 5g of fried Atractylodes macrocephala, 10g of white peony root, 5g of Yuanhu, 5g of Yizhiren, 5g of fried gorgon, 5g of bergamot, 5g of fried toon bark and 5g of nutmeg (all commercially purchased from Beijing Kangrentang Pharmaceutical Co., Ltd. ), mix, add 357.5g of water, soak for 30 minutes, boil on high heat, change to low heat and continue heating for about 20 minutes until the remaining medicinal solution is about 200ml, repeat the above decoction process, and mix the obtained medicinal solution twice.

Embodiment 2

[0032]Weigh 25g of sunburned astragalus, 10g of fried Atractylodes macrocephala, 15g of white peony root, 10g of Yuanhu, 10g of Yizhiren, 10g of fried gorgon, 10g of bergamot, 10g of fried toon skin and 10g of nutmeg (all commercially purchased from Beijing Kangrentang Pharmaceutical Co., Ltd. ), mix, add 605g of water, soak for 30 minutes, boil on high heat, change to low heat and continue heating for about 20 minutes until the remaining medicinal liquid is about 200ml, repeat the above decoction process, and mix the medicinal liquid obtained twice.

Embodiment 3

[0034] Weigh 30g of Radix Astragali Radix, 15g of Fried Atractylodes Rhizome, 20g of Radix Paeoniae Alba, 15g of Peony Root, 15g of Yizhiren, 15g of Fried Gorgon, 15g of Bergamot, 15g of Fried Toon Bark and 15g of Nutmeg (all commercially purchased from Beijing Kangrentang Pharmaceutical Co., Ltd. ), mix, add 852.5g of water, soak for 30 minutes, boil on high heat, change to low heat and continue heating for about 20 minutes until the remaining medicinal solution is about 200ml, repeat the above decoction process, and mix the obtained medicinal solution twice.

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Abstract

The present invention relates to a pharmaceutical composition for preventing and / or treating diarrhea type irritable bowel syndrome (Diarrhea Predominant Irritable Bowel Syndrome, IBS‑D), its preparation method and application, which contains sunburned astragalus, fried Atractylodes macrocephala, Radix Paeoniae Alba, Radix Radix Radix , Yizhiren, fried gorgon, bergamot, fried toon skin and nutmeg. The pharmaceutical composition of the present invention has the following effects: 1. Significantly improve the patient's clinical symptoms; 2. Effectively reduce the degree of abdominal pain in the patient and improve the stool properties of the patient; 3. Significantly improve the quality of life of the patient; 4. Significantly reduce the serum 5-HT level of the patient ; 5. Low recurrence rate.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and specifically relates to a pharmaceutical composition for preventing and / or treating diarrhea-type irritable bowel syndrome, a preparation method and application thereof. Background technique [0002] Irritable bowel syndrome (Irritable Bowel Syndrome, IBS) is a common functional bowel disease in clinical practice. Diarrhea Predominant Irritable Bowel Syndrome (IBS-D) is the most common type. The incidence rate of IBS women is as high as 14-24%, and the incidence rate of men is 5-19%. It has become a global functional bowel disease. The etiology and pathogenesis of IBS are still unclear. It is generally believed that it is related to various factors such as mental psychology, diet, infection, immunity, and genetics. Various etiologies affect the abnormality of brain-gut interaction, and ultimately affect the abnormality of intestinal dynamics and internal organs. Increased sensiti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9062A61K9/16A61K9/00A61P1/00
CPCA61K9/0095A61K9/16A61K36/185A61K36/284A61K36/481A61K36/62A61K36/65A61K36/66A61K36/71A61K36/752A61K36/9062A61P1/00A61K2300/00
Inventor 张声生汪正芳赵鲁卿陶琳吴兵
Owner JIANGSU KANION PHARMA CO LTD
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