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Application of 3,4-dimethoxyphenyl-benzo[d]oxazole as a tumor resistance reversal agent

A drug resistance reversal and tumor technology, which is applied in the direction of antineoplastic drugs, medical preparations containing active ingredients, drug combinations, etc., can solve the problems such as the complex formation mechanism of MDR, and achieve the effect of improving drug resistance of tumor cells

Active Publication Date: 2021-05-11
无锡享源信息科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The formation mechanism of MDR is complex, in which the overexpression of ABC drug transport pump is the main reason for mediating MDR

Method used

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  • Application of 3,4-dimethoxyphenyl-benzo[d]oxazole as a tumor resistance reversal agent
  • Application of 3,4-dimethoxyphenyl-benzo[d]oxazole as a tumor resistance reversal agent
  • Application of 3,4-dimethoxyphenyl-benzo[d]oxazole as a tumor resistance reversal agent

Examples

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Embodiment 1

[0038] In this example, the compound 4,6-di-tert-butyl-2-(3,4-dimethoxyphenyl)benzo[d]oxazole-7-ol (CAS: 175881- 00-2) as an example to illustrate its application as a transport pump inhibitor.

[0039] Cell culture: H460 / MX20 (non-small cell lung cancer drug-resistant cell line with high ABCG2 expression) was cultured in DMEM medium containing 10% fetal bovine serum and 1% penicillin-streptomycin, and the cells were maintained at 37°C containing 5 %CO 2 in a humid incubator.

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Abstract

The present invention specifically relates to the application of 3,4-dimethoxyphenyl-benzo[d]oxazole as a tumor drug resistance reversal agent. In the late stage of tumor treatment, the main reason for the failure of chemotherapy regimens comes from the drug resistance of tumor cells. Existing related studies have shown that the cause of drug resistance in tumor cells is related to drug transporters. The research of the present invention shows that 4,6-di-tert-butyl-2-(3,4-dimethoxyphenyl)benzo[d]oxazole-7-ol can inhibit the transport-related proteins in tumor cells and reverse the Drug resistance can improve the sensitivity of tumor cells to anti-tumor drugs, and can be used as an adjuvant therapy for chemotherapy regimens and co-administered with other anti-tumor drugs, which has good clinical significance.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to 3,4-dimethoxyphenyl-benzo[d]oxazole compounds——4,6-di-tert-butyl-2-(3,4-dimethoxy The application of phenyl) benzo [d] oxazole-7-ol as tumor resistance reversal agent, and the 4,6-di-tert-butyl-2-(3,4-dimethoxyphenyl ) Application of the pharmaceutical composition of benzo[d]oxazole-7-ol in the preparation of antitumor agents. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] The high mortality rate of malignant tumors is often associated with drug resistance in the late stage of cancer, especially multidrug resistance (MDR). MDR refers to the cross-resistance of t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/423A61K31/136A61P35/00A61P35/02C07D263/57
CPCA61K31/136A61K31/423A61P35/00A61P35/02C07D263/57A61K2300/00
Inventor 卢佳澳盛卸晃类红旭赵子婧
Owner 无锡享源信息科技有限公司
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